HOME >> BIOLOGY >> NEWS
Does natural selection drive the evolution of cancer?

(PHILADELPHIA) -- The dynamics of evolution are fully in play within the environment of a tumor, just as they are in forests and meadows, oceans and streams. This is the view of researchers in an emerging cross-disciplinary field that brings the thinking of ecologists and evolutionary biologists to bear on cancer biology.

Insights from their work may have profound implications for understanding why current cancer therapies often fail and how radically new therapies might be devised.

A review by researchers at The Wistar Institute of current research in this new field, published online November 16, will appear in the December issue of the journal Nature Reviews Cancer.

"A tumor cell population is constantly evolving through natural selection," says Carlo C. Maley, Ph.D., an assistant professor in the Molecular and Cellular Oncogenesis Program at Wistar whose own research focuses on this area. He is senior author on the new review. "The mutations that benefit the survival and reproduction of cells in a tumor are the things that drive it towards malignancy.

"Evolution is also driving therapeutic resistance," Maley adds. "When you apply chemotherapy to a population of tumor cells, you're quite likely to have a resistant mutant somewhere in that population of billions or even trillions of cells. This is the central problem in oncology. The reason we haven't been able to cure cancer is that we're selecting for resistant tumor cells. When we spray a field with pesticide, we select for resistant pests. It's the same idea."

Maley notes that there are three necessary and sufficient conditions for natural selection to occur and that all are met in a population of tumor cells. The first requirement is that there be variation in the population. This variation is evident in tumors, which are a mosaic of many different genetic mutants.

The second condition is that the variation must be heritable. This, too, can be s
'"/>

Contact: Franklin Hoke
hoke@wistar.org
215-898-3716
The Wistar Institute
17-Nov-2006


Page: 1 2 3

Related biology news :

1. Innovative research technique reveals another natural wonder in Yellowstone Park
2. Researchers witness natural selection at work in dramatic comeback of male butterflies
3. Sundried tide -- silent, natural disaster
4. Eavesdropping comes naturally to young song sparrows
5. Academy paleontologist and Alaska artist in line for natural history awards
6. Slow but sure -- Burned forest lands regenerate naturally
7. Life-long learning -- nature provides natural inspiration for education
8. Targeting tumors the natural way
9. New research finds that a natural family planning method is as effective as the contraceptive pill
10. Problem forgetting may be a natural mechanism gone awry
11. Hidden-hero microbes in soil, water may help naturally clean toxic sites

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/28/2017)... , Spanien, 27. Februar 2017  EyeLock LLC, ... Iris-Scan, wird seine erstklassige biometrische Lösung zur ... 835 mit X16 LTE auf dem Mobile ... März) am Qualcomm-Stand in Halle 3, Stand ... beinhaltet die Sicherheitsplattform Qualcomm Haven™ – eine ...
(Date:2/21/2017)... and PORTLAND, Ore. , Feb. 22, ... Avamere Family of Companies (Avamere Health Services, Infinity Rehab, ... six-month research study that will apply the power of ... senior living and health centers. By analyzing data streaming ... gain insights into physical and environmental conditions, and obtain ...
(Date:2/13/2017)... Former 9/11 Commission border counsel and Special Counsel to ... of Identity Strategy Partners, LLP, today releases the following ... Protecting the Nation From Foreign Terrorist Entry Into the ... Trump,s ,Travel Ban, Executive Order gains more notoriety and ... ban, it is important that our national discourse regain ...
Breaking Biology News(10 mins):
(Date:3/27/2017)... , March 27, 2017 Roka Bioscience, Inc. ... testing solutions for the detection of foodborne pathogens,  today announced ... Sidoti & Company Spring 2017 Convention on March 29 at ... York Marriott Marquis. About Roka Bioscience ... Roka ...
(Date:3/27/2017)... 2017 Infectex Ltd., a Russian portfolio company of Maxwell Biotech ... SQ109 added to the standard drug therapy regimen in patients with multidrug-resistant pulmonary tuberculosis ... ( USA ) and the US National Institutes of Health. ... ... Fund Logo ...
(Date:3/27/2017)... , ... March 27, 2017 , ... PMG Research ... Collaborations (CTC) conference presented by The Conference Forum in Boston on April 3-4, ... collaborate to drive improved clinical trial outcomes and bring them closer to the patient. ...
(Date:3/27/2017)... NEW YORK , March 27, 2017 /PRNewswire/ ... company developing novel therapies for neurodegenerative diseases, including ... confirmation that its application to list the Company,s ... been approved by The NASDAQ Stock Market, a ... of the listing, Neurotrope will ring the Opening Bell ...
Breaking Biology Technology:
Cached News: