HOME >> BIOLOGY >> NEWS
Dopamine drug leads to new neurons and recovery of function in rat model of Parkinson's

In preliminary results, researchers have shown that a drug which mimics the effects of the nerve-signaling chemical dopamine causes new neurons to develop in the part of the brain where cells are lost in Parkinson's disease (PD). The drug also led to long-lasting recovery of function in an animal model of PD. The findings may lead to new ways of treating PD and other neurodegenerative diseases. The study was funded in part by the NIH's National Institute of Neurological Disorders and Stroke (NINDS).

The study suggests that drugs that affect dopamine D3 receptors might trigger new neurons to grow in humans with the disease. Some of these drugs are commonly used to treat PD. The finding also suggests a way to develop new treatments for PD. The results appear in the July 5, 2006, issue of The Journal of Neuroscience.*

Parkinson's disease, a progressive neurodegenerative disorder that causes tremors, stiffness, slow movements, and impaired balance and coordination, results from the loss of dopamine-producing neurons in part of the brain called the substantia nigra. While many drugs are available to treat these symptoms during the early stages of the disease, the treatments become less effective with time. There are no treatments proven to slow or halt the course of PD. However, many researchers have been trying to find ways of replacing the lost neurons. One possible way to do this would be to transplant new neurons that are grown from embryonic stem cells or neural progenitor cells. However, this type of treatment is very difficult for technical reasons.

The new study, conducted by Christopher Eckman, Ph.D., and Jackalina Van Kampen, Ph.D., at the Mayo Clinic College of Medicine in Jacksonville, Florida, focused on a second possible way to restore function prompting stem cells that normally remain dormant in the adult brain to develop into neurons. While most researchers previously believed the adult brain could
'"/>

Contact: Natalie Frazin
301-496-5924
NIH/National Institute of Neurological Disorders and Stroke
4-Jul-2006


Page: 1 2 3

Related biology news :

1. Dopamine used to prompt nerve tissue to regrow
2. Acute sleep deprivation leads to changes in nighttime urine production for men and women
3. Biodesign Institute leads innovative project to prevent cancer
4. Screening approach leads to discovery of gene linked to breast cancer
5. Alcohol use during pregnancy leads to greater risk of extreme preterm delivery
6. Study of unexplained respiratory infections leads researchers to new virus
7. Penn leads $4 million grant to study gene-environment interactions in lung cancer
8. FSU leads botanical research into 21st century: Deep South Plant Specimen Imaging Project
9. Old dinosaur research leads to new honor
10. Long-term marijuana smoking leads to respiratory complaints
11. Trusting your instincts leads you to the right answer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/20/2017)... 2017 PMD Healthcare announces the release of ... Management System (WMS), a remote, real-time lung health monitoring ... Healthcare is a Medical Device, Digital Health, and Chronic ... creating innovative solutions that empower people to improve their ... PMD developed the first ever personal spirometer, Spiro PD, ...
(Date:3/9/2017)... March 9, 2017 4Dx has publicly released ... Imaging Workshop at the University of Pennsylvania. Founder and ... deliver the latest data to world leaders in lung ... together leaders at the forefront of the industry to ... "The quality of the imaging is ...
(Date:3/7/2017)...   HireVue , the leading provider of video ... best talent, faster, today announced the additions of ... Diana Kucer as Chief Marketing Officer (CMO). ... poised to drive continued growth in the company,s new ... record bookings in 2017. "Companies worldwide turn ...
Breaking Biology News(10 mins):
(Date:4/21/2017)... ... 2017 , ... Having worked on the design of the innovative Triton™ ... to top lab design architects from around the country at the Lab Design Conference ... and Engineering Greg Casey will be at the show, where they will highlight the ...
(Date:4/21/2017)... ... April 21, 2017 , ... The AMA is happy to announce ... from across the nation. The scholarships are created through funds donated by model aviation ... criteria are set by the AMA Scholarship Committee, which is made up of model ...
(Date:4/20/2017)... ... April 20, 2017 , ... As part ... will explore challenging patient cases when screening for direct oral anticoagulant. When patients ... a need for bridging parental anticoagulation especially for those at high risk of ...
(Date:4/20/2017)... ... , ... USDM Life Sciences , the leading risk management, technological innovation ... to announce Holger Braemer as Vice President of its Europe division and ... , Braemer is an integral part of USDM’s expansion of services and solutions ...
Breaking Biology Technology:
Cached News: