HOME >> BIOLOGY >> NEWS
Double identities lie behind chromosome disorders

Chromosome disorders in sex cells cause infertility, miscarriage and irregular numbers of chromosomes (aneuploidy) in neonates. A new study from Karolinska Institutet published in the scientific journal Nature Genetics shows how chromosome disorders can arise when sex cells are formed.

Sex cells contain a control station for monitoring the mechanism that ensures that the correct numbers of chromosomes are distributed during cell division. Scientists have now shown that there is an alternative distribution mechanism in female sex cells that cause chromosome disorders. Aberrant chromosomes orientate themselves like normal chromosomes, and this ability to adopt double identities protects them from detection by the control centre.

We believe that this new fundamental mechanism can help to explain why chromosome disorders are so common in female sex cells, says Professor Christer Hg, leader of the study.

The research might eventually lead to new medical treatments able to reduce the risk of foetal damage.

Over 0.3 per cent of children are born with some kind of chromosome disorder. Most develop Downs Syndrome, or obtain the wrong number of sex chromosomes and develop Turners or Klinefelters syndrome. Turners syndrome only occurs in females and is caused when one of the two X chromosomes is missing. Girls with Turners have arrested development and if no treatment is given do not enter puberty. Klinefelters syndrome affects males, who receive an extra X chromosome. Symptoms include concentration difficulties, poor motor skills and infertility.


'"/>

Contact: Sabina Bossi
sabina.bossi@ki.se
46-852-486-066
Karolinska Institutet
8-Jul-2007


Page: 1

Related biology news :

1. Double honors for diabetes researchers
2. Double honor recognises world-class science and spin-out success
3. Double trouble for RA patients: PLC-gamma-2 regulates osteoclastogenesis and B cell differentiation
4. Double-trouble: Cells with duplicate genomes can trigger tumors
5. Double trouble: Cells with duplicate genomes can trigger tumors
6. Double triumph in stem cell quest
7. Cells take risks with their identities
8. Medium is the message for stem cells in search of identities
9. Identifying the mechanism behind a genetic susceptibility to type 2 diabetes
10. MIT IDs mechanism behind fear
11. University of Manchester researchers reveal clues to new genes behind rheumatoid arthritis

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Double identities lie behind chromosome disorders

(Date:5/6/2015)... AVIV, Israel , May 6, 2015 ... world,s most established helmet producer, announced today that they ... Smart Helmet, the world,s first bio-sensing cycling helmet and ... be released in two new colors in order to ... for the product. In addition, LifeBEAM and Lazer announced ...
(Date:4/27/2015)... April 27, 2015  For more than four decades, ... has been the premier worldwide event for the unmanned ... a must-attend event for any local, national, or trade ... emerging commercial markets and current applications of unmanned technologies. ... this projected $48 billion industry, and how it will ...
(Date:4/27/2015)... Apr. 27, 2015 Profile Solutions, Inc. (OTC: ... security systems is pleased to announce that Dr ... consultant and member of its scientific advisory board. ... as a thought leader in technology-enhanced learning models. He ... and has published studies and books focused on online ...
Breaking Biology News(10 mins):LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4
(Date:5/29/2015)... RESEARCH TRIANGLE PARK, N.C. , May 29, 2015 /PRNewswire/ ... that Roger Jeffs , Ph.D., President and Co-Chief Executive ... on the company,s business at the Jefferies 2015 Global Healthcare ... The presentation and the immediately following Q&A session will ... Eastern Time, and can be accessed via a live webcast ...
(Date:5/29/2015)... Results from a Phase III clinical trial ... to reduce the size of melanoma tumors in patients ... Journal of Clinical Oncology. , The global, randomized ... IV melanoma, a potentially fatal form of skin cancer. ... the safety and efficacy of the oncolytic virus immunotherapy ...
(Date:5/29/2015)... Seoul Semiconductor (CEO: Chung-hoon Lee, http://www.seoulsemicon.com ), ... announced that it will increase the global automotive ... and high reliable LED product line-up for the ... developed efficient and reliable LED packages for the ... headlamps to global auto makers. Seoul Semiconductor’s 14 ...
(Date:5/29/2015)... Worth, Texas (PRWEB) May 29, 2015 Translation ... grow. This is for a good reason--if used in a ... wonders for the offering of a business product or service ... which translation can have a positive effect on a company's ... or service that anyone in the world can use, why ...
Breaking Biology Technology:Study Published in Journal of Clinical Oncology Reports Talimogene Laherparepvec Improvesdurable Responses in Patients with Advanced Melanoma 2Seoul Semiconductor Increases the Global Automotive LED Market Share with its High Efficient and Reliable LEDs for Automotive Lightings 2Three Ways Translation Can Help Businesses Grow 2
Cached News: