HOME >> BIOLOGY >> NEWS
Double identities lie behind chromosome disorders

Chromosome disorders in sex cells cause infertility, miscarriage and irregular numbers of chromosomes (aneuploidy) in neonates. A new study from Karolinska Institutet published in the scientific journal Nature Genetics shows how chromosome disorders can arise when sex cells are formed.

Sex cells contain a control station for monitoring the mechanism that ensures that the correct numbers of chromosomes are distributed during cell division. Scientists have now shown that there is an alternative distribution mechanism in female sex cells that cause chromosome disorders. Aberrant chromosomes orientate themselves like normal chromosomes, and this ability to adopt double identities protects them from detection by the control centre.

We believe that this new fundamental mechanism can help to explain why chromosome disorders are so common in female sex cells, says Professor Christer Hg, leader of the study.

The research might eventually lead to new medical treatments able to reduce the risk of foetal damage.

Over 0.3 per cent of children are born with some kind of chromosome disorder. Most develop Downs Syndrome, or obtain the wrong number of sex chromosomes and develop Turners or Klinefelters syndrome. Turners syndrome only occurs in females and is caused when one of the two X chromosomes is missing. Girls with Turners have arrested development and if no treatment is given do not enter puberty. Klinefelters syndrome affects males, who receive an extra X chromosome. Symptoms include concentration difficulties, poor motor skills and infertility.


'"/>

Contact: Sabina Bossi
sabina.bossi@ki.se
46-852-486-066
Karolinska Institutet
8-Jul-2007


Page: 1

Related biology news :

1. Double honors for diabetes researchers
2. Double honor recognises world-class science and spin-out success
3. Double trouble for RA patients: PLC-gamma-2 regulates osteoclastogenesis and B cell differentiation
4. Double-trouble: Cells with duplicate genomes can trigger tumors
5. Double trouble: Cells with duplicate genomes can trigger tumors
6. Double triumph in stem cell quest
7. Cells take risks with their identities
8. Medium is the message for stem cells in search of identities
9. Identifying the mechanism behind a genetic susceptibility to type 2 diabetes
10. MIT IDs mechanism behind fear
11. University of Manchester researchers reveal clues to new genes behind rheumatoid arthritis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/22/2016)... NEW YORK , December 22, 2016 ... global provider of secure solutions for the e-Government, Public Safety, HealthCare, ... a subsidiary of SuperCom, has been selected to implement and deploy ... county in Northern California , further expanding its ... ...
(Date:12/16/2016)... DUBLIN , Dec 16, 2016 Research ... Access System Market - Global Forecast to 2021" report to ... ... projected to grow at a CAGR of 14.06% from 2016 to ... 2016, and is projected to reach 854.8 Million by 2021. The ...
(Date:12/15/2016)... 2016 Advancements in biometrics will ... and wellbeing (HWW), and security of vehicles ... passenger vehicles begin to feature fingerprint recognition, ... beat monitoring, brain wave monitoring, stress detection, ... pulse detection. These will be driven by ...
Breaking Biology News(10 mins):
(Date:1/24/2017)... ... January 24, 2017 , ... Nor-Tech’s leading-edge demo cluster is ... bootable Intel KNL. , Currently Cal Tech researchers are testing their code ... demo cluster is a no-cost, no-strings opportunity for current and prospective clients to ...
(Date:1/24/2017)... ... 23, 2017 , ... Edward Buckler, Ph.D., a research geneticist ... Academy of Sciences Prize in Food and Agriculture Sciences. He is being honored ... Academy of Sciences (NAS) Prize in Food and Agriculture Sciences was established in ...
(Date:1/24/2017)... January 23, 2017 According to ... by Type (Genetic, Cell-based (CD34, PBMC, BLT)), Application (Neuroscience, ... (Pharmaceutical & Biotech Companies, CRO) - Global Forecast to ... Humanized Mouse Model Market for the forecast period of ... USD 116.0 Million by 2021 from USD 73.3 Million ...
(Date:1/24/2017)... , Jan. 23, 2017 /PRNewswire/ - BioAmber Inc. (NYSE: ... into an underwriting agreement with Rodman & Renshaw, a ... as sole book running manager and representative of several underwriters, ... a firm commitment basis a minimum of 2,105,264 shares ... to purchase a minimum of 1,052,632 shares of common ...
Breaking Biology Technology:
Cached News: