HOME >> BIOLOGY >> NEWS
Double identities lie behind chromosome disorders

Chromosome disorders in sex cells cause infertility, miscarriage and irregular numbers of chromosomes (aneuploidy) in neonates. A new study from Karolinska Institutet published in the scientific journal Nature Genetics shows how chromosome disorders can arise when sex cells are formed.

Sex cells contain a control station for monitoring the mechanism that ensures that the correct numbers of chromosomes are distributed during cell division. Scientists have now shown that there is an alternative distribution mechanism in female sex cells that cause chromosome disorders. Aberrant chromosomes orientate themselves like normal chromosomes, and this ability to adopt double identities protects them from detection by the control centre.

We believe that this new fundamental mechanism can help to explain why chromosome disorders are so common in female sex cells, says Professor Christer Hg, leader of the study.

The research might eventually lead to new medical treatments able to reduce the risk of foetal damage.

Over 0.3 per cent of children are born with some kind of chromosome disorder. Most develop Downs Syndrome, or obtain the wrong number of sex chromosomes and develop Turners or Klinefelters syndrome. Turners syndrome only occurs in females and is caused when one of the two X chromosomes is missing. Girls with Turners have arrested development and if no treatment is given do not enter puberty. Klinefelters syndrome affects males, who receive an extra X chromosome. Symptoms include concentration difficulties, poor motor skills and infertility.


'"/>

Contact: Sabina Bossi
sabina.bossi@ki.se
46-852-486-066
Karolinska Institutet
8-Jul-2007


Page: 1

Related biology news :

1. Double honors for diabetes researchers
2. Double honor recognises world-class science and spin-out success
3. Double trouble for RA patients: PLC-gamma-2 regulates osteoclastogenesis and B cell differentiation
4. Double-trouble: Cells with duplicate genomes can trigger tumors
5. Double trouble: Cells with duplicate genomes can trigger tumors
6. Double triumph in stem cell quest
7. Cells take risks with their identities
8. Medium is the message for stem cells in search of identities
9. Identifying the mechanism behind a genetic susceptibility to type 2 diabetes
10. MIT IDs mechanism behind fear
11. University of Manchester researchers reveal clues to new genes behind rheumatoid arthritis

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Double identities lie behind chromosome disorders

(Date:7/30/2014)... of the Entomological Society of America (ESA) has elected ... election as a Fellow acknowledges outstanding contributions to entomology ... extension, or administration. The following Fellows will be recognized ... which will be held November 16-19, 2014 in Portland, ... a professor with the Department of Plant, Soil and ...
(Date:7/30/2014)... Laboratory has received a pledge of $1 million from ... the Laboratory,s new Neurobehavioral Biometry Center. , ... will enable the Laboratory to develop a greater breadth ... ultimate goal of accelerating the pace of research to ... as a premier resource for the Laboratory and its ...
(Date:7/30/2014)... a changing climate threaten some of the world,s ... conservationists establish seed collections to save the seeds ... preserving some genetic diversity., For decades, these seed ... offer a one-size-fits-all approach for how many seeds ... samples regardless of species, pollination mode, growth habitat ...
Breaking Biology News(10 mins):Entomological Society of America recognizes 2014 fellows 2Entomological Society of America recognizes 2014 fellows 3Entomological Society of America recognizes 2014 fellows 4Entomological Society of America recognizes 2014 fellows 5Entomological Society of America recognizes 2014 fellows 6Entomological Society of America recognizes 2014 fellows 7Entomological Society of America recognizes 2014 fellows 8Entomological Society of America recognizes 2014 fellows 9Entomological Society of America recognizes 2014 fellows 10Entomological Society of America recognizes 2014 fellows 11Entomological Society of America recognizes 2014 fellows 12Entomological Society of America recognizes 2014 fellows 13Entomological Society of America recognizes 2014 fellows 14Entomological Society of America recognizes 2014 fellows 15Entomological Society of America recognizes 2014 fellows 16Entomological Society of America recognizes 2014 fellows 17Rossi Foundation pledges $1M for JAX neurobehavioral research center 2Saving seeds the right way can save the world's plants 2
(Date:7/31/2014)... Boston, MA (PRWEB) July 31, 2014 ... ) finds itself flush with innovative adult stem cell ... patents and has three additional patent applications ... Office. , The patented inventions address two of the ... and regenerative medicine. Adult stem cells are difficult ...
(Date:7/30/2014)... MD (PRWEB) July 30, 2014 ... today the release of the REVELERIS® Prep ... organic chemists, preparative chromatographers, and other researchers to ... using a single unit. , With the REVELERIS® ... flash and preparative chromatography modes with a simple ...
(Date:7/30/2014)... July 30, 2014  Replikins Ltd. today released new ... Ebola virus. Before the current outbreaks, the mean Ebola ... amino acids) between 1995 and 2002 was 1.1; the ... 2012, and sixteen-fold in 2013, thus predicting the current ... technology has been shown to be able to predict ...
(Date:7/30/2014)... 2014   Wyle has been named ... Mission Support Services (FILMSS) contract awarded by the ... terms of the contract, Wyle will provide mission ... Calif. In particular, Wyle will provide program and ... on the International Space Station and collaborative science ...
Breaking Biology Technology:The Adult Stem Cell Technology Center, LLC Launches A Marketing Campaign To License Adult Stem Cell Biotechnologies 2The Adult Stem Cell Technology Center, LLC Launches A Marketing Campaign To License Adult Stem Cell Biotechnologies 3Grace Launches New REVELERIS® Prep Purification System 2Wyle Wins NASA's Fully Integrated Lifecycle Mission Support Services Contract 2
Cached News: