HOME >> BIOLOGY >> NEWS
Double-trouble: Cells with duplicate genomes can trigger tumors

The idea that a failure of proper cell division produces genomic instability and promotes the development of cancer was first proposed by German biologist Theodor Boveri in 1915. The fact that tumor cells often have abnormal numbers of chromosomes supports this theory, and two papers published by Harvard Medical School researchers provide new, more direct evidence to support this.

David Pellman, Harvard Medical School associate professor of pediatrics at Dana-Farber Cancer Institute and Children's Hospital Boston, and colleagues tested the theory by blocking cell division in cells that also lack the tumor suppressor gene p53, to generate tetraploid cells - cells that contain a double quota of chromosomes. Compared to their diploid counterparts, which have a normal set of chromosomes, tetraploid cells were more prone to generate tumors in mice, and these tumors showed genomic instability similar to many human cancers.

Another study by Randall King, HMS assistant professor of cell biology, shows how tetraploid cells can arise. He shows that inaccurate segregation even of a single pair of chromosomes - an error that does occur randomly will halt cell division and produce tetraploid cells. Together, these papers lend experimental support to Boveri's ideas that errors in cell division contribute to the development of cancer.


'"/>

Contact: Leah Gourley
public_affairs@hms.harvard.edu
617-432-0442
Harvard Medical School
14-Oct-2005


Page: 1

Related biology news :

1. Cells take risks with their identities
2. Cells re-energize to come back from the brink of death
3. Need oxygen? Cells know how to spend and save
4. Cells selectively absorb short nanotubes
5. Cells use noise to make cell-fate decisions
6. Cells in the lung clear the air to prevent lung damage
7. Cells passed from mother to child during pregnancy live on and make insulin
8. Cells, dyes and videotape: Online scientific methods journal incorporates multimedia
9. Cells use mix-and-match approach to tailor regulation of genes
10. Cells in mucus from lungs of high-risk patients can predict tumor development
11. Double trouble: Cells with duplicate genomes can trigger tumors

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/11/2020)... ... February 11, 2020 , ... ... problems for life sciences companies and government agencies, announced the recent appointment ... consulting expertise to Tunnell, with significant experience assessing, designing, and managing enterprise ...
(Date:2/6/2020)... ... February 06, 2020 , ... Kerafast Inc. ... bioresearch materials, today announced an agreement with The Good Food Institute , ... reality. Under the partnership, terrestrial meat and aquatic cell lines will be made ...
(Date:1/29/2020)... (PRWEB) , ... January 29, 2020 , ... ... lead the new Analytics and Data Sciences practice, providing consulting services for strategy, ... appointment was announced by Mike Townley, co-founder and Managing Partner of CREO, an ...
Breaking Biology News(10 mins):
(Date:1/24/2020)... Va. (PRWEB) , ... January 24, 2020 , ... ... other innovations created by companies in biotechnology, diagnostics, therapeutics, laboratory and clinical services ... of millions of people around the world. And as Slone Partners ...
(Date:1/23/2020)... ... January 22, 2020 , ... ... in the cosmetic surgery industry at two recent North American investor forums specializing ... the Canaccord Genuity Medical Technologies & Diagnostics Forum on November 21, 2019 in ...
(Date:1/22/2020)... ... 21, 2020 , ... Microbial Discovery Group LLC (MDG) is ... and Institutional (I&I) Account Manager. Darrell will focus on servicing MDG’s partners with ... 30 years of sales experience working across multiple different market sectors such as; ...
(Date:1/22/2020)... (PRWEB) , ... January 21, 2020 , ... QCDx ... liquid biopsy from a simple blood draw, today announced the sale of the proprietary ... The Rare Scope will be used in clinical cancer research. , “The RareScope can ...
Breaking Biology Technology:
Cached News: