HOME >> BIOLOGY >> NEWS
Double-trouble: Cells with duplicate genomes can trigger tumors

The idea that a failure of proper cell division produces genomic instability and promotes the development of cancer was first proposed by German biologist Theodor Boveri in 1915. The fact that tumor cells often have abnormal numbers of chromosomes supports this theory, and two papers published by Harvard Medical School researchers provide new, more direct evidence to support this.

David Pellman, Harvard Medical School associate professor of pediatrics at Dana-Farber Cancer Institute and Children's Hospital Boston, and colleagues tested the theory by blocking cell division in cells that also lack the tumor suppressor gene p53, to generate tetraploid cells - cells that contain a double quota of chromosomes. Compared to their diploid counterparts, which have a normal set of chromosomes, tetraploid cells were more prone to generate tumors in mice, and these tumors showed genomic instability similar to many human cancers.

Another study by Randall King, HMS assistant professor of cell biology, shows how tetraploid cells can arise. He shows that inaccurate segregation even of a single pair of chromosomes - an error that does occur randomly will halt cell division and produce tetraploid cells. Together, these papers lend experimental support to Boveri's ideas that errors in cell division contribute to the development of cancer.


'"/>

Contact: Leah Gourley
public_affairs@hms.harvard.edu
617-432-0442
Harvard Medical School
14-Oct-2005


Page: 1

Related biology news :

1. Cells take risks with their identities
2. Cells re-energize to come back from the brink of death
3. Need oxygen? Cells know how to spend and save
4. Cells selectively absorb short nanotubes
5. Cells use noise to make cell-fate decisions
6. Cells in the lung clear the air to prevent lung damage
7. Cells passed from mother to child during pregnancy live on and make insulin
8. Cells, dyes and videotape: Online scientific methods journal incorporates multimedia
9. Cells use mix-and-match approach to tailor regulation of genes
10. Cells in mucus from lungs of high-risk patients can predict tumor development
11. Double trouble: Cells with duplicate genomes can trigger tumors

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/8/2017)... About Voice Recognition Biometrics Voice recognition biometrics ... a stored voiceprint template. Acoustic features of an ... are compared to distinguish between individual voices. Voice ... PCs already have a microphone and can authenticate ... are most likely to be deployed in telephone-based ...
(Date:2/8/2017)... 2017 The biometrics market has reached ... of organizations, desires to better authenticate or identify ... and challenge questions), biometrics is quickly working its ... market is driven by use cases, though there ... enterprise uses cases, with consumer-facing use cases encompassing ...
(Date:2/7/2017)... , Feb. 7, 2017 Zimmer Biomet Holdings, ... musculoskeletal healthcare, will present at the LEERINK Partners 6th ... Palace Hotel on Wednesday, February 15, 2017 at 10 ... of the presentation can be accessed at http://wsw.com/webcast/leerink28/zbh ... the conference via Zimmer Biomet,s Investor Relations website at ...
Breaking Biology News(10 mins):
(Date:2/23/2017)... and NEW YORK , Feb. ... Lumeon , a leading digital health company, and ... provider of telemedicine and remote patient monitoring, announce ... telemedicine reimbursements.  DN Telehealth maximizes ... in real-time, extending consultations beyond a physical clinical ...
(Date:2/23/2017)... , Feb. 23, 2017  MIODx announced today ... two key immunotherapy technologies from the University of ... a method to monitor a patient for response ... and CTLA-4.  The second license extends the technology ... is likely to have an immune-related adverse event ...
(Date:2/23/2017)... ... February 23, 2017 , ... Brain Sentinel, ... begin marketing the SPEAC® System, the Brain Sentinel® Seizure Monitoring and Alerting System. ... healthcare facilities during periods of rest. A lightweight, non-invasive monitor is placed on ...
(Date:2/23/2017)... Winston-Salem, NC (PRWEB) , ... February 23, 2017 , ... ... pleased to announce a new partnership with Compass Research . GGI's mission is ... gifting a vaccine to a child in need in honor of each clinical trial ...
Breaking Biology Technology:
Cached News: