HOME >> BIOLOGY >> NEWS
Double-trouble: Cells with duplicate genomes can trigger tumors

The idea that a failure of proper cell division produces genomic instability and promotes the development of cancer was first proposed by German biologist Theodor Boveri in 1915. The fact that tumor cells often have abnormal numbers of chromosomes supports this theory, and two papers published by Harvard Medical School researchers provide new, more direct evidence to support this.

David Pellman, Harvard Medical School associate professor of pediatrics at Dana-Farber Cancer Institute and Children's Hospital Boston, and colleagues tested the theory by blocking cell division in cells that also lack the tumor suppressor gene p53, to generate tetraploid cells - cells that contain a double quota of chromosomes. Compared to their diploid counterparts, which have a normal set of chromosomes, tetraploid cells were more prone to generate tumors in mice, and these tumors showed genomic instability similar to many human cancers.

Another study by Randall King, HMS assistant professor of cell biology, shows how tetraploid cells can arise. He shows that inaccurate segregation even of a single pair of chromosomes - an error that does occur randomly will halt cell division and produce tetraploid cells. Together, these papers lend experimental support to Boveri's ideas that errors in cell division contribute to the development of cancer.


'"/>

Contact: Leah Gourley
public_affairs@hms.harvard.edu
617-432-0442
Harvard Medical School
14-Oct-2005


Page: 1

Related biology news :

1. Cells take risks with their identities
2. Cells re-energize to come back from the brink of death
3. Need oxygen? Cells know how to spend and save
4. Cells selectively absorb short nanotubes
5. Cells use noise to make cell-fate decisions
6. Cells in the lung clear the air to prevent lung damage
7. Cells passed from mother to child during pregnancy live on and make insulin
8. Cells, dyes and videotape: Online scientific methods journal incorporates multimedia
9. Cells use mix-and-match approach to tailor regulation of genes
10. Cells in mucus from lungs of high-risk patients can predict tumor development
11. Double trouble: Cells with duplicate genomes can trigger tumors

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/6/2016)... 2016 Securus Technologies, a leading provider ... public safety, investigation, corrections and monitoring, and the ... five (5) year funding commitment by Securus to ... rehabilitation and reentry support to more inmates and ... 2004, the Prison Entrepreneurship Program (PEP) is an ...
(Date:12/2/2016)... , December 1, 2016 ... (Fingerprint, Voice), Future Technology (Iris Recognition System), Vehicle ... - Global Forecast to 2021", published by MarketsandMarkets, ... Million in 2016, and is projected to grow ... CAGR of 14.06%.      (Logo: http://photos.prnewswire.com/prnh/20160303/792302) ...
(Date:11/30/2016)... WARSAW, Poland , Nov. 30, 2016 Not many of us realize ... crucial aspects of recovery so we need to do it well. Inadequate sleep levels ... problems, high blood pressure, stroke, diabetes, and even cancer. Maybe now is ... Christmas present that could help them to manage their sleep quality? ... ...
Breaking Biology News(10 mins):
(Date:12/7/2016)... report "Acrylic Processing Aid Market by Polymer Type (PVC), Fabrication Process (Extrusion, Injection Molding), End-Use ... published by MarketsandMarkets, the global market size was USD 645.4 Million in 2016, ... CAGR of 6.2% between 2016 and 2026. Continue ... ... , , ...
(Date:12/7/2016)... 2016  Genprex, Inc. a biopharmaceutical company focused ... today announced that it has retained ICR Healthcare, ... communications and advisory firm, to develop and implement ... combine investor relations, public relations and digital communications ... of Genprex and its lead candidate Oncoprex, which ...
(Date:12/7/2016)... and ANN ARBOR, Mich. , ... biopharmaceutical company developing breakthrough immune modulatory medicines, announced today ... the Company,s lead therapeutic candidate, LYC-30937- E nteric ... a debilitating skin disease that is estimated to affect ... United States , with approximately 1.5 - 3 ...
(Date:12/7/2016)... CA (PRWEB) , ... December 07, 2016 , ... ... wastewater treatment and resource recovery solutions for industrial facilities, today announced that one ... be the first to use Cambrian’s novel water-energy purchase agreement (WEPA). Under the ...
Breaking Biology Technology:
Cached News: