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Drug combo may reduce protease inhibitor-related hardening of the arteries

ction of proteins.

What's more, NRTI reduced the negative effect of macrophages and cholesterol without reducing the effectiveness that ritonavir had against HIV. "So by giving both drugs at the same time, you get the positive effects of the protease inhibitors without the negative effect of hardening of the arteries," Smart concluded.

The researchers are now beginning a short-term study with healthy human volunteers to see if the protease inhibitor/NRTI drug combination will help control the production of CD36 in humans as well, Smart said.

"We'll try to find out if the NRTI regimen can keep the CD-36 protein in check in the non-infected volunteers," Smart said. If the drug combination works, the researchers will move to further clinical trials.


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Contact: Christine Guilfoy
cguilfoy@the-aps.org
301-634-7253
American Physiological Society
5-Sep-2006


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