HOME >> BIOLOGY >> NEWS
Drug protects brain cells in Huntington's disease model, researchers find

DALLAS July 24, 2007 A drug used in some countries to treat the symptoms of Huntingtons disease prevents death of brain cells in mice genetically engineered to mimic the hereditary condition, UT Southwestern Medical Center researchers have found.

The research sheds light on the biochemical mechanisms involved in the disease and suggests new avenues of study for preventing brain-cell death in at-risk people before symptoms appear.

The drug can actually prevent brain cells from dying, said Dr. Ilya Bezprozvanny, associate professor of physiology at UT Southwestern. Its much more important than people thought.

The study, of which Dr. Bezprozvanny is senior author, appears in the July 25 issue of The Journal of Neuroscience.

The drug, called tetrabenazine (TBZ), is commercially distributed as Xenazine or Nitoman and blocks the action of dopamine, a compound that some nerve cells use to signal others. TBZ is approved for use in several countries, but not the U.S., to treat uncontrollable muscle movements in Huntingtons and other neurological conditions.

Huntingtons is a fatal genetic condition that usually manifests around ages 30 to 45, according to the Huntingtons Disease Society of America. About one in 10,000 people in America have the disease, with another 200,000 at risk. One of the most famous people with Huntingtons was folk singer Woody Guthrie, who died in 1967.

Huntingtons is caused by a dominant gene, meaning that a person carrying the gene is certain to develop the disease and has a 50 percent chance of passing it on to his or her children. Symptoms include jerky, uncontrollable movements called chorea and deterioration of reasoning abilities and personality. Symptoms begin after many brain cells have already died.

Although a genetic test exists, some people with a family history of Huntingtons choose not to be tested because there is no cure and because they fear loss of h
'"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
24-Jul-2007


Page: 1 2

Related biology news :

1. Reading ability protects brain from lead exposure
2. Research shows NPD1 protects a key component of vision
3. A gene that protects from kidney disease
4. PINK1 protects from Parkinsons
5. Enzyme delivered in smaller package protects cells from radiation damage
6. Parkinsons protein protects neurons from stress induced cell death
7. Caspase-14 protects our skin against UVB and dehydration
8. Reproductive speed protects large animals from being hunted to extinction
9. Molecule that destroys bone also protects it, new research shows
10. Peramivir protects mice from lethal H5N1 infection
11. Estrogen protects liver after traumatic injury

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2019)... LAKE CITY, and MARTINSRIED, Germany (PRWEB) , ... ... ... in high-throughput antibody screening and characterization, announced today that they have opened a ... Carterra’s platform has fueled the need for the new office. , The Munich ...
(Date:8/14/2019)... JOLLA, Calif. (PRWEB) , ... August 14, 2019 , ... ... insight into their future children, announces inclusion in the 38th annual Inc. 500|5000 ... been eligible to apply. To qualify, companies must have been founded and generating revenue ...
(Date:8/9/2019)... ... August 09, 2019 , ... With a demand in healthcare to ... patients will visit urgent care centers (UCC) in the coming years, according to a ... The Market for Urgent Care Centers , is a detailed look at the current ...
Breaking Biology News(10 mins):
(Date:8/14/2019)... ... August 13, 2019 , ... ... on prepackaged mobile phases for QC laboratories. After gaining a few significant clients, ... sciences approach into a valued supplier of manufacturing processing solutions, including reagents for ...
(Date:8/6/2019)... ... August 06, 2019 , ... ... characterizing microbiome populations down to the strain level, has announced partnerships with six ... other products to companies and research organizations in Australia, Benelux, Indonesia, Korea, Malaysia, ...
(Date:7/30/2019)... SAN DIEGO (PRWEB) , ... July 30, 2019 ... ... Lajollacooks4u, San Diego’s premiere team building and cooking events company. Not only has ... but it has also started offering Private Cooking Parties to its guests. , ...
(Date:7/19/2019)... NEWPORT BEACH, Calif. (PRWEB) , ... July 18, ... ... who is also known as “Ravi Everest,” will be joining forces with California-based ... to be held from July 20-22nd. Coalition Duchenne raises awareness and funding for ...
Breaking Biology Technology:
Cached News: