HOME >> BIOLOGY >> NEWS
Drug that interrupts a key stage of cell division shows promise for advanced solid tumors

Prague, Czech Republic: One of the first studies to investigate the effects of a new anti-cancer drug in patients with advanced or metastatic solid tumours has shown that it is capable of halting progression of the disease, and the study has provided the first proof of the drug's mechanism of action.

The drug works by blocking aurora proteins, which play a key role in cell division and are implicated in the onset and progression of cancer. It was discovered and characterised by scientists at Nerviano Medical Sciences in Italy.

Dr Maja de Jonge, a medical oncologist at the Erasmus University Medical Centre, Rotterdam, The Netherlands, told the EORTC-NCI-AACR [1] Symposium on Molecular Targets and Cancer Therapeutics in Prague today (Wednesday 8 November): "So far we have tested the drug in 36 patients in a phase I clinical trial. All the patients had advanced solid cancers that were progressing at the time they entered the trial. However, in seven of these patients the disease stabilised and has remained stable in four of the patients for seven months or more. Without the drug we would have expected to see their disease continue to progress."

Aurora proteins belong to a family of enzymes that regulate the different steps in mitosis when the cell nucleus divides into two identical cells. The enzymes help the dividing cell to share its genetic material between the daughter cells, and they are essential for cell proliferation. Aurora proteins are over-expressed in cancer and this causes unequal distribution of the genetic material, creating abnormal cells the hallmark of cancer. However, it is only recently that scientists have started to investigate the proteins as targets for anti-cancer therapies, and this is one of the first studies to investigate an aurora kinase inhibitor in patients.

Dr de Jonge and her colleagues tested an aurora kinase inhibitor PHA-739358. Her patients had a range of solid tumours: colorectal
'"/>

Contact: Emma Mason
wordmason@mac.com
44-077-112-96986
European Organisation for Research and Treatment of Cancer
8-Nov-2006


Page: 1 2 3

Related biology news :

1. 454 sequencing identifies HIV drug resistance at early stage
2. Ultra deep sequencing identifies HIV drug resistance at early stage
3. Fibers are center stage at international conference
4. Early-stage sperm cells created from human bone marrow
5. Bridge protein spurs deadliest stages of breast cancer
6. In many habitats, competition is the drama, but benefactors set the stage
7. Scientists discover stage at which an embryonic cell is fated to become a stem cell
8. Nano-devices hold promise for early-stage cancer detection
9. Setting the stage to find drugs against SARS
10. Towards predicting late-stage radiation toxicity
11. New research finds surveys of larval-stage organisms effective for measuring marine biodiversity

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... , ... August 24, 2020 , ... ... the treatment of chronic inflammatory and fibrotic diseases, today announced that Dr. Stacie ... of Drug Discovery. , Dr. Canan previously served as Executive Director of Global ...
(Date:8/26/2020)... ... August 25, 2020 , ... Catalent, the leading global provider ... gene therapies, and consumer health products, today announced that two Catalent Biologics experts ... taking place between Aug. 31 – September 4, 2020. , On Wednesday, Sept. ...
(Date:8/23/2020)... (PRWEB) , ... August 21, 2020 , ... ... Rigaku Corporation has been published and is now available on the company’s ... X-ray diffraction—serves the X-ray analysis community, presenting current news and crystallographic research. ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... eSource has long been touted as the ... the history of eSource, the reasons it did not take off as quickly as ... source, the industry is moving towards capturing data electronically for clinical trials and then ...
(Date:7/18/2020)... ... July 16, 2020 , ... After research model surgery and catheter ... great surgery is only the beginning of a successful study, while protecting and accessing ... Brad Gien, Global Head of Surgery from Envigo in a live ...
(Date:7/10/2020)... Va. (PRWEB) , ... July 08, 2020 , ... ... testing services and products, announces a significant expansion of laboratory operations through its ... collection for agencies implementing testing programs. , Bode-CARES provides a ...
(Date:7/7/2020)... DIEGO (PRWEB) , ... July 06, 2020 , ... R3 ... new program featuring up to 200 million stem cells. Depending on the patient's condition, ... seniors in the US will die having some form of Alzheimers dementia, and the ...
Breaking Biology Technology:
Cached News: