HOME >> BIOLOGY >> NEWS
Dying cells encourage neighbors to grow

Researchers from The Rockefeller University have uncovered specific mechanisms by which cells that are genetically programmed to commit suicide stimulate growth in surrounding cells. The research, published online in Developmental Cell, provides new information about how normal, healthy tissues are maintained and may shed some light on a pathway that may contribute to tumor growth.

It has been known for some time that cells that die as a result of injury-provoked programmed cell death, also known as apoptosis, may stimulate the growth of surrounding cells. "Such compensatory mechanisms may be essential to allow for the elimination of as many damaged or dangerous cells as needed without compromising organismal fitness. In spite of its importance, the underlying mechanisms are poorly understood," explains study leader Dr. Hermann Steller.

Dr. Steller and colleagues demonstrate that when cells from the imaginal disc in the fruit fly Drosophila are stimulated to undergo apoptosis but experimentally manipulated so that they do not actually die ("undead cells"), they stimulate the growth of neighboring tissue. The researchers demonstrate that the undead cells promote cell growth in the surrounding imaginal disc by activating specific signaling cascades that are known to be required for cell proliferation. Although artificial, the experimental creation of undead cells allows this phenomenon to be expanded and studied. The authors provide evidence that apoptotic cells that are allowed to complete the process of dying also secrete the growth-stimulating signals.

The researchers conclude that apoptotic cells actively induce compensatory proliferation by activating growth-associated signaling pathways and secreting molecules that promote growth in surrounding tissues. They also suggest that abnormal regulation of apoptosis, as has been shown to be the case in some cancers, may result in pathological activation of these pathways. "Based on the be
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
5-Oct-2004


Page: 1 2

Related biology news :

1. Low oxygen likely made Great Dying worse, greatly delayed recovery
2. Newly created cancer stem cells could aid breast cancer research
3. ESF EURYI award winner aims to stop cancer cells reading their own DNA
4. OHSU turns mouse into factory for human liver cells
5. UCLA scientists produce functioning neurons from human embryonic stem cells
6. UCF research links proteins, stem cells and potential Alzheimers treatment
7. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
8. In a first, Einstein scientists discover the dynamics of transcription in living mammalian cells
9. How cells change the pace of their steps
10. Discredited Korean embryonic stem cells true origins revealed
11. A low expression of MX2 gene exists in the white blood cells of narcoleptics

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/10/2020)... ... ... Today CJ BIO announced the first in a series of Food Ingredient ... that is revolutionizing ingredient mixes, nutritional content and flavor profiles across a range of ... 2020 at11:00 AM (CDT) during SHIFT20, the virtual edition of the IFT Annual Meeting ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com , ... biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European Hematology ... Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase 1 ...
(Date:7/1/2020)... (PRWEB) , ... July 01, 2020 , ... ... that it had completed the purchase of Teva-Takeda Pharmaceuticals’ packaging facility in Minakuchi, ... company’s existing Japanese clinical supply facility located in Kakegawa, the new 60,000-square-foot facility ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... The SDX® Respiratory ... 16 countries, has reached its 20th anniversary of worldwide use. Introduced in the ... top universities including University of Pennsylvania, University of Michigan, University of Maryland, University ...
(Date:7/18/2020)... ... ... After research model surgery and catheter implantation, the long journey of catheter maintenance and ... successful study, while protecting and accessing the catheter or device post-surgery is often undervalued ... Envigo in a live webinar on Wednesday, August 5, 2020 at ...
(Date:7/18/2020)... ... 17, 2020 , ... dicentra , a leading Contract ... industries, is pleased to announce that Charles Galea has joined its clinical trials ... is an accomplished and results-driven sales executive with over 10 years of expertise ...
(Date:7/10/2020)... ... 09, 2020 , ... In most research using the zebrafish ... formation in zebrafish embryos, maintaining optical transparency to facilitate microscopic imaging. Over the ... using the zebrafish model to investigate the causes of leukaemia and its relationship ...
Breaking Biology Technology:
Cached News: