HOME >> BIOLOGY >> NEWS
ENCODE map changes view of the human genome landscape

Since the completion of the Human Genome Project in 2003, research efforts have been aimed at analyzing the functions of various sequences in the genome, using both experimental and computational strategies. The June issue of Genome Research (www.genome.org) is devoted to The ENCODE (ENCyclopedia Of DNA Elements) Project, whose goal is to characterize all functional elements in the human genome. Genome Researchs ENCODE issue includes 25 research papers, which report on the validation of the main results of the pilot project and are essential the community as they scale up to cataloguing functional elements in the whole genome.

In addition, the issue also contains commentary and perspectives on how our views of the genome have changed as a result of the ENCODE investigations. The major findings span the areas of chromatin and replication, gene transcription and regulation, and evolutionary constraint, some of which are highlighted below. The entire issue will be freely available online on June 14 to coordinate with the ENCODE consortium publication in the journal Nature.

1. Pervasive transcription, fewer boundaries

Dr. Alexandre Reymond and colleagues conducted a series of experiments to annotate all 399 protein-coding genes in the ENCODE regions. In doing so, they found that more than half of the genes produced transcripts that contained sequences mapping outside of the known boundaries of these genes. Interestingly, these transcribed sequences often overlapped with other genes, were located a significant distance from the main portion of the coding sequence, and spanned large genomic segments.

Our results modify our current understanding of the architecture and regulation of protein-coding genes, explains Dr. Reymond. Furthermore, some sequence polymorphisms hitherto considered to be located in non-coding regions may ultimately be related to disease.


'"/>

Contact: Maria Smit
smit@cshl.edu
516-422-4127
Cold Spring Harbor Laboratory
13-Jun-2007


Page: 1 2 3 4 5

Related biology news :

1. CSHL selected for odENCODE Data Coordination Center
2. NYUs Center for Comparative Functional Genomics part of $57 million MOD-ENCODE consortium
3. ENCODE consortium publishes scientific strategy
4. Acute sleep deprivation leads to changes in nighttime urine production for men and women
5. Marine phytoplankton changes form to protect itself from different predators
6. Small-scale agricultural changes may help eradicate widespread disease
7. Nanotechnology requires immediate changes in EPA
8. K-State to collaborate on research to forecast ecological consequences of environmental changes
9. Scientists: As rainfall changes, tropical plants may acclimate
10. Fish growth changes enhanced by climate change
11. Common fungicide causes long-term changes in mating behavior

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/30/2019)... PALO ALTO, Calif. (PRWEB) , ... ... ... Foresight Institute, a leading think tank, research, and public interest organization focused ... the prestigious Distinguished Student Prize. , The Award recognizes the College graduate ...
(Date:9/24/2019)... BUDAPEST, Hungary and CAMBRIDGE, Mass. (PRWEB) , ... ... ... headquartered in Budapest with US offices in Cambridge, MA, announce today that Holotype ... oral presentation at the annual meeting of the American Society for Histocompatibility ...
(Date:9/17/2019)... ... September 17, 2019 , ... VISTAAR released ADVISORY Playbooks ... or as re-assurance / 2nd opinion to their internal strategies they formed for developing ... when going into new markets, or planning to change their product elements and want ...
Breaking Biology News(10 mins):
(Date:10/3/2019)... , ... October 01, 2019 , ... Cheyenne is a ... Mimi, Cheyenne’s owner, owns and operates Rebel’s Run , which offers riding ... favorite amongst students and trail riding guests. Mimi describes her as her “go ...
(Date:10/3/2019)... ... October 02, 2019 , ... ... spectrometry, is pleased to announce that it has moved into a new, 5000 ... analytical instruments, the new facility demonstrates the company's continuous commitment to quality research ...
(Date:9/24/2019)... ... September 24, 2019 , ... Drug resistance has been declared as one ... with MRSA becoming one of the most serious concerns. Hong Kong cannot be spared ... community-associated MRSA (CA-MRSA), or a seven-fold of the figure in 2007 – the year ...
(Date:9/24/2019)... ... September 24, 2019 , ... In the past three years, ... by faculty at South Dakota School of Mines & Technology that expands ... attach to surfaces to form a slimy and yet strong layer which is commonly ...
Breaking Biology Technology:
Cached News: