HOME >> BIOLOGY >> NEWS
Early environmental exposure may accelerate age-related neurodegeneration

WASHINGTON, DC June 27, 2007 -- Exposure to iron during the first weeks of life in combination with exposure later in life to a common herbicide may contribute to the subsequent degeneration of brain cells associated with the onset of Parkinsons disease (PD), according to a new study in mice. The findings also showed that a compound that protects cells in the body from damage from certain forms of oxygen, a kind of antioxidant, could suppress such neural degeneration.

Previous studies indicated that both early exposure to iron and later exposure to the herbicide paraquat independently increase oxidative stressan environment in which damage from levels of reactive oxygen is more likelyin dopamine-producing regions of the brain, areas that are affected by PD. Julie Andersen, PhD, and her team at the Buck Institute for Age Research found that feeding iron to newborn mice made them more susceptible to paraquat, which increases levels of harmful forms of oxygen and damages dopamine-producing neurons as they grew older. The study appears in the June 27 issue of The Journal of Neuroscience.

The importance of the study is that it points to a possible role of common mechanisms triggered by iron and paraquat as important in PD, and suggests that therapies that block their effects would be worth testing in patients, says Marie-Francoise Chesselet, MD, PhD, of UCLA, who did not participate in the study.

Ten-day-old mice were fed iron for a week. At ages from two months to two years, they were then exposed to paraquat for three weeks. By examining their brains, Andersen and her team found that by the time the mice were a year old, early iron consumption exacerbated damage to brain cells caused by paraquat exposure. The effect was even more pronounced at two years of age, the human equivalent of 6070 years.

A subset of mice that received the antioxidant at the same time that they were exposed to paraquat exhibited reduced leve
'"/>

Contact: Sara Harris
sharris@sfn.org
202-962-4000
Society for Neuroscience
27-Jun-2007


Page: 1 2

Related biology news :

1. Early fire risk for mountains near Los Angeles
2. Early exposure to indoor fungus molecules may protect infants against future allergies
3. Early-stage sperm cells created from human bone marrow
4. Early Europeans unable to stomach milk
5. Early HIV treatment fails to restore memory T cells
6. Early Earth haze may have spurred life, says University of Colorado study
7. Early detection
8. Early family experience can reverse the effects of genes, UCLA psychologists report
9. Early to bed, early to rise
10. Early exposure to synthetic estrogen puts DES Daughters at higher risk for breast cancer
11. Top researcher-educators receive Presidential Early Career Award for Scientists and Engineers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/12/2017)... 2017  New research undertaken by Fit Small Business ... 1,000 participants were simply asked which office technology had they ... consider standard issue.  Insights on what will be ... from futurists and industry leaders including Penelope Trunk , ... Some of these findings included; ...
(Date:1/11/2017)... 11, 2017 Intoxalock, a leading ignition interlock ... of its patent-pending calibration device. With this new technology, ... securely upload data logs and process repairs at service ... "Fighting drunk driving through the application of cutting-edge ... large, but also for the customer who can get ...
(Date:1/6/2017)... Calif. , Jan. 6, 2017  Privately-held ... safety studies in healthy volunteers of a novel ... to treat acute pancreatitis. Acute ... typically a mild disorder, but can be very ... failure and sepsis, where extended hospital stays, time ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... ... 2017 , ... November Research Group, LLC, a global leader ... manufacturers and regulators, is proud to announce the worldwide release of PRIMO Mail. ... provide product vigilance departments with the flexibility and ease of use of a ...
(Date:1/19/2017)... Linda, Ca (PRWEB) , ... January 18, 2017 ... ... virtual events for tech innovators, engineers, and scientists from around the world, was ... American News. The awards program is based entirely on merit and decided upon ...
(Date:1/19/2017)... -- Acupath Laboratories, Inc., a leading provider of sub-specialized ... Committee that will guide the company,s vision and strategy ... , a 15-year veteran of the anatomic pathology industry, ... Chief Sales Officer .  Prior to joining Acupath ... leadership roles at several leading lab industry organizations including, ...
(Date:1/18/2017)... Jan. 18, 2017 Applied BioMath ( ... to drug research and development, today announced that ... and CEO of Applied BioMath, will present at ... Modeling (BAGIM) Meeting on Thursday January 19, 2017 ... , MA.   Dr. Burke,s talk "Quantitative Modeling ...
Breaking Biology Technology:
Cached News: