HOME >> BIOLOGY >> NEWS
Early environmental exposure may accelerate age-related neurodegeneration

WASHINGTON, DC June 27, 2007 -- Exposure to iron during the first weeks of life in combination with exposure later in life to a common herbicide may contribute to the subsequent degeneration of brain cells associated with the onset of Parkinsons disease (PD), according to a new study in mice. The findings also showed that a compound that protects cells in the body from damage from certain forms of oxygen, a kind of antioxidant, could suppress such neural degeneration.

Previous studies indicated that both early exposure to iron and later exposure to the herbicide paraquat independently increase oxidative stressan environment in which damage from levels of reactive oxygen is more likelyin dopamine-producing regions of the brain, areas that are affected by PD. Julie Andersen, PhD, and her team at the Buck Institute for Age Research found that feeding iron to newborn mice made them more susceptible to paraquat, which increases levels of harmful forms of oxygen and damages dopamine-producing neurons as they grew older. The study appears in the June 27 issue of The Journal of Neuroscience.

The importance of the study is that it points to a possible role of common mechanisms triggered by iron and paraquat as important in PD, and suggests that therapies that block their effects would be worth testing in patients, says Marie-Francoise Chesselet, MD, PhD, of UCLA, who did not participate in the study.

Ten-day-old mice were fed iron for a week. At ages from two months to two years, they were then exposed to paraquat for three weeks. By examining their brains, Andersen and her team found that by the time the mice were a year old, early iron consumption exacerbated damage to brain cells caused by paraquat exposure. The effect was even more pronounced at two years of age, the human equivalent of 6070 years.

A subset of mice that received the antioxidant at the same time that they were exposed to paraquat exhibited reduced leve
'"/>

Contact: Sara Harris
sharris@sfn.org
202-962-4000
Society for Neuroscience
27-Jun-2007


Page: 1 2

Related biology news :

1. Early fire risk for mountains near Los Angeles
2. Early exposure to indoor fungus molecules may protect infants against future allergies
3. Early-stage sperm cells created from human bone marrow
4. Early Europeans unable to stomach milk
5. Early HIV treatment fails to restore memory T cells
6. Early Earth haze may have spurred life, says University of Colorado study
7. Early detection
8. Early family experience can reverse the effects of genes, UCLA psychologists report
9. Early to bed, early to rise
10. Early exposure to synthetic estrogen puts DES Daughters at higher risk for breast cancer
11. Top researcher-educators receive Presidential Early Career Award for Scientists and Engineers

Post Your Comments:
(Date:5/18/2015)... 2015 Fingerprint Cards (FPC) has received ... FPC1155 and FPC1035 from one if its module partners. Deliveries ... Q3 2015 and the sensors will be used by smartphone ... for 2015 hereby amount to 740 MSEK to date. In ... MSEK and a number of smaller orders not separately communicated ...
(Date:5/14/2015)... 14, 2015  Verificient Technologies, Inc., a ... online remote proctoring, announced a new alliance ... and creator of the Canvas Learning Management ... companies will benefit from the seamless integration ... As a fully integrated multifactor biometrics behavioral ...
(Date:5/11/2015)...  Through a well-rounded UAS delegation representing private industry, government, ... showing at AUVSI,s Unmanned 2015 conference last week in ... UAS industry met with over 200 hundred people ... the UAS ecosystem. "Our message is clear ... Aerospace Rich Knoll . "If you want to fly ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Verificient and Instructure Announce Alliance Partnership to Provide Online Proctoring for K-12 and Higher Education Institutions 2Ohio Flies High at Unmanned '15, Sets Stage for Ohio UAS Conference 2
(Date:5/29/2015)... May 29, 2015 Delcath Systems, Inc. ... medical device company focused on oncology with an ... liver cancers, announces that results of a large, ... melanoma patients with hepatic metastases with the Delcath ... in an on-line abstract at the American Society ...
(Date:5/29/2015)... May 29, 2015  Caris Life Sciences ® ... the promise of precision medicine, today announced the ... the clinical utility of Caris Molecular Intelligence ® ... in helping to identify targeted treatment options for ... of the studies, results of which are to ...
(Date:5/29/2015)... (PRWEB) May 29, 2015 Results from ... talimogene laherparepvec and its ability to reduce the size ... have been published in the Journal of Clinical Oncology. ... with stages IIIB, IIIC and IV melanoma, a potentially ... the study was to evaluate the safety and efficacy ...
(Date:5/28/2015)... 28, 2015 Research ... addition of Jain PharmaBiotech,s new report  "Alzheimer ...  to their offering.       (Logo: ... challenge in management. With nearly 8 million ... major markets of the world and anticipated ...
Breaking Biology Technology:Positive Data With Delcath's CHEMOSAT Highlighted At ASCO 2015 2Positive Data With Delcath's CHEMOSAT Highlighted At ASCO 2015 3Positive Data With Delcath's CHEMOSAT Highlighted At ASCO 2015 4Positive Data With Delcath's CHEMOSAT Highlighted At ASCO 2015 5Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 2Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 3Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 4Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 5Multi-Platform Tumor Profiling from Caris Life Sciences Identifies Targeted Treatment Options for Patients with Rare and/or Aggressive Tumors 6Study Published in Journal of Clinical Oncology Reports Talimogene Laherparepvec Improvesdurable Responses in Patients with Advanced Melanoma 2Global Alzheimer Disease Report 2015-2024 - New Drugs, Markets and Companies 2Global Alzheimer Disease Report 2015-2024 - New Drugs, Markets and Companies 3
Cached News: