HOME >> BIOLOGY >> NEWS
Early function of specialized neurons marks 'first light' in retinal maturation

Researchers have discovered that a set of light-responsive retinal cells that form connections to the circadian clock are functional very early in development, from the day of birth. Although the cells are sensitive to light, they do not participate in image formation, a process that matures later on.

The work has been reported in the journal Current Biology by Sumathi Sekaran, of Imperial College London, and colleagues there and at John Hopkins University and the University of Manchester.

The visual system is known to be composed of the classical image-forming pathway, which involves the function of rod and cone photoreceptors, as well as the more recently discovered non-image-forming pathway, which involves specialized neurons called intrinsically photoreceptive retinal ganglion cells (ipRGCs). Although extensive research has characterized the delayed functional maturation of rod and cone photoreception, information pertaining to the development of the ipRGCs has been lacking. It was known, however, that a photopigment present in mature ipRGCs, retinal melanopsin, is expressed long before the classical rod and cone photopigments.

The new research directly studied the functional development of the ipRGCs in mice via a range of approaches, including the examination of melanopsin expression, the physiological recording of ganglion-cell light responses, and the measuring of functional outputs of these cells to higher brain regions. The researchers found that, quite remarkably, the melanopsin-expressing ganglion cells are present in abundance and act as functional photoreceptors from the day of birth, when it has been widely assumed the mouse retina lacks photodetection. At the time of birth, a significant percentage of cells in the retinal ganglion-cell layer express melanopsin and respond to light.

At this early age, these cells provide input conveying light conditions to the suprachiasmatic nucleus, the site of the central circadian p
'"/>

Contact: Heidi Hardman
hhardman@cell.com
1-617-397-2879
Cell Press
16-Jun-2005


Page: 1 2

Related biology news :

1. Early fire risk for mountains near Los Angeles
2. Early environmental exposure may accelerate age-related neurodegeneration
3. Early exposure to indoor fungus molecules may protect infants against future allergies
4. Early-stage sperm cells created from human bone marrow
5. Early Europeans unable to stomach milk
6. Early HIV treatment fails to restore memory T cells
7. Early Earth haze may have spurred life, says University of Colorado study
8. Early detection
9. Early family experience can reverse the effects of genes, UCLA psychologists report
10. Early to bed, early to rise
11. Early exposure to synthetic estrogen puts DES Daughters at higher risk for breast cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/19/2020)... (PRWEB) , ... June 18, 2020 , ... Join experts ... Zhao, PhD, Principal Scientist in a live webinar on Wednesday, July 8, ... have simplified the way we genetically engineer new models. However, while modifying the genome ...
(Date:6/5/2020)... ... ... “Although we are disappointed to have to make this decision our primary ... We remain committed to creating a global platform to showcase the science, and ... of WMIS. , The abstract deadline for the virtual meeting is ...
(Date:5/28/2020)... ... 2020 , ... Today bioinformatics leader hc1® announced ... lab testing insights and hc1’s exclusive Local Risk Index in a unified CV19 ... employees returning to the workplace. , “Some of the best ways to keep ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... ... the leading global provider of advanced delivery technologies, development, and manufacturing solutions for ... they have entered into a strategic partnership whereby Catalent will provide support for ...
(Date:7/18/2020)... ... July 16, 2020 , ... After research model surgery and catheter implantation, ... surgery is only the beginning of a successful study, while protecting and accessing the ... Gien, Global Head of Surgery from Envigo in a live webinar ...
(Date:7/10/2020)... ... July 09, 2020 , ... ... of Technology (MIT) has expanded the company’s exclusive license to include clinical ... the point-of-care diagnostic market, focusing initially on the SARS-CoV-2 biosensor. CANARY’s™ ...
(Date:7/1/2020)... ... June 29, 2020 , ... MedShift , a ... 2020, despite many obstacles created as a result of COVID-19. As a provider ... partnered medical practices and medical manufacturers by expanding access to device offerings, technology ...
Breaking Biology Technology:
Cached News: