HOME >> BIOLOGY >> NEWS
Early life stress can inhibit development of brain-cell communication zones, UCI study finds

Irvine, Calif., Oct. 20, 2004 -- High stress levels during infancy and early childhood can lead to the poor development of communication zones in brain cells a condition found in mental disorders such as autism, depression and mental retardation.

These are the findings of Dr. Tallie Z. Baram and her collaborators at the UC Irvine College of Medicine, Neurocrine Biosciences, Inc., and the Max Planck Institute of Psychiatry. For the first time, the researchers have identified how increased amounts of a key messenger for stress, the neuropeptide CRH, can inhibit the normal growth of dendrites, which are branch-like protrusions of neurons that send and receive messages from other brain cells.

The researchers believe CRH ultimately may be responsible for these poorly developed zones in brain cells. Results of their study appear in the current online early edition of the Proceedings of the National Academy of Sciences.

"These findings may prove to be highly relevant for understanding the origins of several human brain disorders, and they also point to some potential preventive treatments," said Baram, the Danette Shepard Chair in Neurological Studies. "The activation of stress hormones and molecules seems to initiate a complex cascade of brain effects that is related to depression and dementia. This study reveals a novel role of CRH in this cascade."

Communication among brain cells is the foundation of cognitive processes such as learning and memory. In several human brain disorders where learning and similar thought processes are abnormal, dendrites in the hippocampus where learning and memory occurs - have been found to be small or poorly developed. Normally, CRH is found in the hippocampus, and small amounts that are released during stress may improve cellular communication.

But when the investigators in this study grew the hippocampus of baby rats in a dish and administered higher doses of CRH to the cultured hippoca
'"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
20-Oct-2004


Page: 1 2

Related biology news :

1. Early fire risk for mountains near Los Angeles
2. Early environmental exposure may accelerate age-related neurodegeneration
3. Early exposure to indoor fungus molecules may protect infants against future allergies
4. Early-stage sperm cells created from human bone marrow
5. Early Europeans unable to stomach milk
6. Early HIV treatment fails to restore memory T cells
7. Early Earth haze may have spurred life, says University of Colorado study
8. Early detection
9. Early family experience can reverse the effects of genes, UCLA psychologists report
10. Early to bed, early to rise
11. Early exposure to synthetic estrogen puts DES Daughters at higher risk for breast cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/17/2017)... Florida , April 17, 2017 NXT-ID, ... technology company, announces the filing of its 2016 Annual Report on ... and Exchange Commission. ... on Form 10-K is available in the Investor Relations section of ... as on the SEC,s website at http://www.sec.gov . ...
(Date:4/13/2017)... According to a new market research report "Consumer IAM Market by ... Service, Authentication Type, Deployment Mode, Vertical, and Region - Global Forecast to ... USD 14.30 Billion in 2017 to USD 31.75 Billion by 2022, at ... ... MarketsandMarkets Logo ...
(Date:4/11/2017)... Research and Markets has announced the addition ... their offering. ... tracking market to grow at a CAGR of 30.37% during the ... 2017-2021, has been prepared based on an in-depth market analysis with ... its growth prospects over the coming years. The report also includes ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... ... August 15, 2017 , ... Nanomedical ... and biotherapeutics development, announces the launch of the new NHS Agile biosensor ... kinetic binding data for a wide range of molecules, including small and large ...
(Date:8/15/2017)... , ... August 15, 2017 , ... The Conference ... on Immuno-Oncology 360° (IO360°) programming through a series of upcoming panels and events. The ... 7-9, 2018, at The Roosevelt Hotel in New York City. , “With our experience ...
(Date:8/14/2017)... ... 2017 , ... Opal Kelly, a leading producer of powerful ... the release of SYZYGY™, a new open standard for connecting high-performance peripherals to ... low cost, low pin-count, high-performance connectivity solution between FPGAs and single-purpose hardware peripherals. ...
(Date:8/11/2017)... ... August 11, 2017 , ... Algenist continues to disrupt the ... collagen like never before. , Collagen is the key structural element skin needs ... Liquid Collagen™, which include: , First to market with ...
Breaking Biology Technology:
Cached News: