HOME >> BIOLOGY >> NEWS
Early life stress harms mental function and immune system in later years

tal rats lived with their mothers led to emotional stress of both the mothers and their pups. All evidence of this stress disappeared by the time the pups reached adulthood. However, starting in middle age, these so-called "graduates" of early life stress began to forget the location of objects they had seen before. They also got worse at recognizing objects they had encountered on the previous day. These difficulties worsened as the rats grew older, much more rapidly than in rats that were raised for their first week of life under more nurturing conditions.

In collaboration with Gary Lynch, PhD, and Eniko Kramar, PhD, also of the University of California , Irvine, Brunson and Baram found that communication between brain cells, considered to be the cellular basis for learning and memory, was faulty in the middle-aged rats. Recordings of the electrical activity of brain cells appeared normal in young adult rats exposed to early life stress, but became very disturbed as they reached middle age.

"Now that concrete deficits in brain cell communication have been found in the early-life stressed, demented rats, it may be feasible to find the specific molecules involved and design medicines to prevent the deficits," Baram says.

In other work, researchers showed in rats that stress during the last third of pregnancy affects the ability of adult offspring to respond to challenges to their immune system. Heather Richardson, PhD, and her colleagues Soon Lee, PhD; Dong Seo, PhD, and Catherine Rivier, PhD, at the Salk Institute in La Jolla, Calif., found that the changes in the offsprings' response to immune challenges may be due in part to deficits in nitric oxide, a signaling system in the brain known to connect the immune and stress systems.

Twenty-nine pregnant rats were exposed daily to one of two stresses during the last third of their pregnancies; controls in this group were left alone. Adult female offspring were
'"/>

Contact: Leah Ariniello
dawn@sfn.org
202-462-6688
Society for Neuroscience
24-Oct-2004


Page: 1 2 3 4 5 6

Related biology news :

1. Early fire risk for mountains near Los Angeles
2. Early environmental exposure may accelerate age-related neurodegeneration
3. Early exposure to indoor fungus molecules may protect infants against future allergies
4. Early-stage sperm cells created from human bone marrow
5. Early Europeans unable to stomach milk
6. Early HIV treatment fails to restore memory T cells
7. Early Earth haze may have spurred life, says University of Colorado study
8. Early detection
9. Early family experience can reverse the effects of genes, UCLA psychologists report
10. Early to bed, early to rise
11. Early exposure to synthetic estrogen puts DES Daughters at higher risk for breast cancer

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Early life stress harms mental function and immune system later years

(Date:8/19/2014)... Efforts must be made to decrease China,s increasing caesarean ... August) in BJOG: An International Journal of Obstetrics ... the highest caesarean delivery rates in the world. Of ... by caesarean. Although the exact rate is not known, ... China reports total caesarean rates ranging from 36% to ...
(Date:8/19/2014)... used in supermarkets to encourage healthier spending habits? A ... that very question by tracking the purchasing records in ... to rate the nutritional value of foods for sale. ... David Just, PhD, and Brian Wansink PhD, author of ... over 150 Hannaford Supermarkets in the Northeastern United States ...
(Date:8/19/2014)... and Network-Level Science, , Imagine if we had the ... was responding to global changes in real time. Such ... multiple decades of information about ecological responses to environmental ... of different ecosystem types. , In fact, this ... Network, which will soon celebrate its 35th anniversary. , ...
Breaking Biology News(10 mins):Is China's 50 percent cesarean section delivery rate too high? 2Is China's 50 percent cesarean section delivery rate too high? 3This week from AGU: Long-term ecological research, predicting cholera outbreaks 2
(Date:8/20/2014)... improve the health of your heart, researchers have discovered. ... a standard TENS machine like those designed to relieve ... the small raised flap at the front of the ... The stimulation changed the influence of the nervous system ... can drive failing hearts too hard. , Professor Jim ...
(Date:8/19/2014)... 19, 2014 Shimadzu Scientific Instruments ... Prominence-i and Nexera-i, adding to the company’s extensive ... functionality, an intuitive operating environment, and full automation, ... efficient workflow for conventional to ultra-high-speed analysis. ... and intelligent design so users can begin building ...
(Date:8/19/2014)... DUBLIN , Aug. 19, 2014 Research ... Oxide Fuel Cells (SOFCs) - Global Strategic Business Report" ... the worldwide markets for Solid Oxide Fuel Cells (SOFCs) in ... US, Canada , Europe ... Annual estimates and forecasts are provided for the period 2012 ...
(Date:8/19/2014)... , Aug. 19, 2014 CSSi, the ... industry, recently announced the formation of the company,s Medical ... announce the addition of Dr. William E. Gannon, ... http://photos.prnewswire.com/prnh/20140818/136957 The MCAB, with ... variety of therapeutic areas and set strategic goals for ...
Breaking Biology Technology:'Tickling' your ear could be good for your heart 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 3Global Solid Oxide Fuel Cells (SOFCs) - Strategic Business Report 2014 2CSSi Appoints Dr. William E. Gannon, Jr. to Newly Formed Medical and Clinical Advisory Board 2CSSi Appoints Dr. William E. Gannon, Jr. to Newly Formed Medical and Clinical Advisory Board 3
Cached News: