Early life stress harms mental function and immune system in later years

tal rats lived with their mothers led to emotional stress of both the mothers and their pups. All evidence of this stress disappeared by the time the pups reached adulthood. However, starting in middle age, these so-called "graduates" of early life stress began to forget the location of objects they had seen before. They also got worse at recognizing objects they had encountered on the previous day. These difficulties worsened as the rats grew older, much more rapidly than in rats that were raised for their first week of life under more nurturing conditions.

In collaboration with Gary Lynch, PhD, and Eniko Kramar, PhD, also of the University of California , Irvine, Brunson and Baram found that communication between brain cells, considered to be the cellular basis for learning and memory, was faulty in the middle-aged rats. Recordings of the electrical activity of brain cells appeared normal in young adult rats exposed to early life stress, but became very disturbed as they reached middle age.

"Now that concrete deficits in brain cell communication have been found in the early-life stressed, demented rats, it may be feasible to find the specific molecules involved and design medicines to prevent the deficits," Baram says.

In other work, researchers showed in rats that stress during the last third of pregnancy affects the ability of adult offspring to respond to challenges to their immune system. Heather Richardson, PhD, and her colleagues Soon Lee, PhD; Dong Seo, PhD, and Catherine Rivier, PhD, at the Salk Institute in La Jolla, Calif., found that the changes in the offsprings' response to immune challenges may be due in part to deficits in nitric oxide, a signaling system in the brain known to connect the immune and stress systems.

Twenty-nine pregnant rats were exposed daily to one of two stresses during the last third of their pregnancies; controls in this group were left alone. Adult female offspring were

Contact: Leah Ariniello
Society for Neuroscience

Page: 1 2 3 4 5 6

Related biology news :

1. Early fire risk for mountains near Los Angeles
2. Early environmental exposure may accelerate age-related neurodegeneration
3. Early exposure to indoor fungus molecules may protect infants against future allergies
4. Early-stage sperm cells created from human bone marrow
5. Early Europeans unable to stomach milk
6. Early HIV treatment fails to restore memory T cells
7. Early Earth haze may have spurred life, says University of Colorado study
8. Early detection
9. Early family experience can reverse the effects of genes, UCLA psychologists report
10. Early to bed, early to rise
11. Early exposure to synthetic estrogen puts DES Daughters at higher risk for breast cancer

Post Your Comments:

(Date:3/29/2017)... March 29, 2017  higi, the health IT company ... North America , today announced a Series ... acquisition of EveryMove. The new investment and acquisition accelerates ... tools to transform population health activities through the collection ... higi collects and secures data today on ...
(Date:3/24/2017)... , March 24, 2017 The Controller General of ... Mr. Abdulla Algeen have received the prestigious international IAIR Award ... Continue Reading ... ... and Deputy Controller Abdulla Algeen (small picture on the right) have received ...
(Date:3/23/2017)... Research and Markets has announced the addition of the ... to 2025" report to their offering. ... The Global Vehicle Anti-Theft System Market ... the next decade to reach approximately $14.21 billion by 2025. ... for all the given segments on global as well as regional ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... DuPont Pioneer and ... they have entered into a multiyear collaboration to identify and characterize novel CRISPR-Cas ... tools for gene editing across all applications. , Under the terms of the ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... President Andi Purple announced Dr. Suneel I. Sheikh, the co-founder, CEO and chief ... ), Inc. has been selected for membership in ARCS Alumni Hall of ...
(Date:10/11/2017)... -- VMS BioMarketing, a leading provider of patient support solutions, has ... (CNE) network, which will launch this week. The VMS CNEs ... professionals to enhance the patient care experience by delivering peer-to-peer ... care professionals to help women who have been diagnosed and ... ...
(Date:10/10/2017)... ... 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, has ... The bold new look is part of a transformation to increase awareness, appeal to ... period. , It will also expand its service offering from its signature gourmet cooking ...
Breaking Biology Technology:
Cached News: