HOME >> BIOLOGY >> NEWS
Eat less, weigh more? Enzyme makes lean mice 'susceptible' to dietary fat

Working with genetically engineered mice, Johns Hopkins scientists have interfered with the brain's ability to control an animal's response to a high-fat diet. The report, to be published in the latest issue of the Proceedings of the National Academy of Sciences online the week of May 1, is based on the identification of a gene - CPT1c - the brain needs to manage body weight.

According to the researchers, the CPT1c gene protects against weight gain caused by a high-fat diet. So-called knockout mice lacking the CPT1c gene gain more weight than their littermates carrying normal copies of the gene.

"We think our study reveals a direct weight management pathway," says Michael Wolfgang, Ph.D., a postdoctoral fellow in the Department of Biological Chemistry at The Johns Hopkins University School of Medicine and an author of the report. "CPT1c seems to allow the body to respond immediately to the level of nutrients and fat in the bloodstream."

Hopeful that the discovery has broad implications for understanding the genetic underpinnings of obesity and weight management, the Hopkins investigators say the work affirms the central role of the brain in managing hunger and satiety and offers up new targets for drugs that manipulate CPT1c. But none have been developed so far, says Wolfgang.

The newly discovered gene makes a protein found only in the brain, notably in the region that controls hunger, thirst and metabolism - the hypothalamus. Proteins similar to CPT1c are known to help break down fat to release energy to feed cells. Mice lacking the CPT1c gene are the same length as their littermates who carry normal copies of the gene but on average weigh 15 percent less when fed a low-fat diet.

Further analysis revealed that when deprived of food for four hours prior to feeding with standard laboratory mouse chow, the knockout mutant mice ate about 25 percent less food than their normal siblings. Therefore, the researchers conclude
'"/>

Contact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
2-May-2006


Page: 1 2 3

Related biology news :

1. Adult survivors of childhood leukemia exercise less, worsening high risk for obesity and illness
2. Losing weight after pregnancy -- diet and exercise better than diet alone
3. Fine particulate matter from traffic may influence birth weight
4. Nanotechnology: consumers must be convinced benefits outweigh risks
5. Researchers isolate new risk marker for overweight children
6. Lack of sun does not explain low vitamin D in elderly who are overweight
7. Its safe for obese moms-to-be to lose weight during pregnancy, new SLU research finds
8. Clock gene plays role in weight gain, study finds
9. 100 percent juice not associated with overweight in children
10. How does soy promote weight loss? University of Illinois scientist finds another clue
11. Milk beats soy for post-weighlifting muscle gain

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/30/2017)... Va. , June 30, 2017 ... leading developer and supplier of face and eye ... ATA Featured Product provider program. ... an innovative way to monitor a driver,s attentiveness ... greatly from being able to detect fatigue and ...
(Date:5/16/2017)... 2017   Bridge Patient Portal , an ... MD EMR Systems , an electronic medical record ... have established a partnership to build an interface ... GE Centricity™ products, including Centricity Practice Solution (CPS), ... These new integrations will allow healthcare delivery networks ...
(Date:4/17/2017)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... 2016 Annual Report on Form 10-K on Thursday April 13, 2017 ... ... Investor Relations section of the Company,s website at http://www.nxt-id.com  under ... http://www.sec.gov . 2016 Year Highlights: ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... 2017 , ... Proscia Inc ., a data solutions ... “Pathology is going digital. Is your lab ready?” with Dr. Nicolas Cacciabeve, Managing ... how Proscia improves lab economics and realizes an increase in diagnostic confidence.* ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... granted orphan drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator ... osteosarcoma. SBT-100 is able to cross the cell membrane and bind intracellular STAT3 ...
(Date:10/10/2017)... Oct. 10, 2017 International research firm Parks Associates ... speak at the TMA 2017 Annual Meeting , October 11 in ... the residential home security market and how smart safety and security products ... Parks Associates: Smart ... "The residential security market ...
(Date:10/9/2017)... ... October 09, 2017 , ... The award-winning American Farmer ... first quarter 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. , With ... with the challenge of how to continue to feed a growing nation. At the ...
Breaking Biology Technology:
Cached News: