A simple dietary supplement taken during pregnancy could prevent the brain defect resulting from hydrocephalus, revolutionary research suggests.

Now, parents of children suffering from the condition in the United States have stumped up the money to pay for the next stage of their investigations.

The money will fund a lab at the University of Central Florida headed by the British researchers, who hope their work will lead to a significant reduction in the risk of hydrocephalus and treat, perhaps even cure, those cases that do occur.

"Fetal-onset hydrocephalus results in a blockage in brain development which everyone has always thought was brain damage due to fluid accumulation," said Dr Jaleel Miyan, the University of Manchester scientist leading the research.

"There is currently no unequivocal prenatal diagnosis test or satisfactory treatment other than surgical diversion of the fluid through a tube, known as a shunt, from the brain to the abdomen or heart. Shunts are permanent and prone to infection and blockage so that patients may require several operations during their lifetime.

"This procedure is based on the established clinical view that this fluid is nothing more than a mechanical support system within the skull with little, if any, physiological properties and that hydrocephalus is simply a build up of excess cerebrospinal fluid in the brain.

"But our studies have shown that the condition may in fact cause a change in the composition of the fluid and that it is this chemical change that prevents normal cell division resulting in arrested brain development.

"We have also been excited by the results of tests that have shown it may be possible to 'unlock' the potentia
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Contact: Aeron Haworth
aeron.haworth@manchester.ac.uk
44-161-275-8383
University of Manchester
23-Nov-2005