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Effectiveness of certain antidepressants may be influenced by gene variations of individuals

responses to antidepressants with different targets have significant associations with homologous monoamine transporter gene polymorphisms. Our data confirm a relationship between SSRI response and 5-HTT polymorphisms, and establish an association between NRI response and the NET G1287A polymorphism. We also found that the 5-HTTLPR s/l variation plays a role in the treatment of depression with both NRI and SSRI agents. The results of this study need to be confirmed in other populations, using selective NRIs other than nortriptyline. Additional studies in younger populations with depression are also needed," the researchers write. "Confirmation of these preliminary findings would permit refined pharmacogenetic selection of antidepressant treatment."


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Contact: Doh Kwan Kim
paulkim@smc.samsung.co.kr
JAMA and Archives Journals
3-Oct-2006


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