HOME >> BIOLOGY >> NEWS
Einstein researchers identify genetic variants that lend clues to living longer

Many studies show that tweaking a single gene can extend life span in animal models. In a new study, Drs. Gil Atzmon and Nir Barzilai at the Albert Einstein College of Medicine of Yeshiva University have found that people harbor alleles--alternative forms of a gene--that confer the same sort of longevity advantage.

The researchers looked for genetic clues to longevity in a group of 214 Ashkenazi Jews who have passed or nearly reached 100 years of age. In the April 4 issue of PLoS Biology, they report that a specific genetic profile, or genotype, was associated with longevity as well as cardiovascular health, lower incidence of hypertension and healthy insulin metabolism.

"Since centenarians typically escape cardiovascular disease, diabetes, and other age-related disorders, we suspected these most senior of senior citizens might possess gene variations that help them reach a ripe old age," said Dr. Nir Barzilai, director of the Institute for Aging Research at Einstein and senior author on the paper. "If so, then these genotypes should occur with higher frequency in centenarians than in the rest of us."

Dr. Barzilai and his colleagues recruited Ashkenazi Jews for the study, because this population--descended from a founder group of just 30,000 or so people--is more genetically uniform than other groups, simplifying the challenge of associating a genotype with its physical manifestation (phenotype).

When studying centenarians, finding an age-matched control group is obviously difficult. But since longevity runs in families, the researchers were able to get around this problem by recruiting children of the centenarians and matching them against a control group consisting of other Ashkenazi Jews the same age.

Each participant had blood drawn--to determine their genotype and to measure levels of several cardiovascular disease markers including insulin, cholesterol, triglycerides, high-density lipoproteins (HDL, the "good" choles
'"/>

Contact: Karen Gardner
kgardner@aecom.yu.edu
718-430-3101
Albert Einstein College of Medicine
3-Apr-2006


Page: 1 2 3

Related biology news :

1. In a first, Einstein scientists discover the dynamics of transcription in living mammalian cells
2. Einstein researchers prototype vaccine could provide improved protection against tuberculosis
3. Einstein researchers discover radiation-eating fungi
4. Einsteins Dr. Vern Schramm elected to the National Academy of Sciences
5. Einstein researchers discover how a key dietary vitamin is absorbed
6. NCI funds Einstein and U. Albany NanoCollege to make worlds smallest cancer detection device
7. Team at CNSE and Einstein receive grant to develop worlds smallest cancer detection device
8. Einstein researchers demonstrate a novel approach to treating AIDS
9. Einsteins Dr. E. Richard Stanley receives 2006 E. Donnall Thomas Prize
10. Einstein researchers find key to unlocking worlds deadliest malaria parasite
11. Findings by Einstein scientists reveal possible strategy against obesity, diabetes and infertility

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2018)... ... August 30, 2018 , ... Vinita Madill, ... Novak, infrared materials engineer, LightPath Technologies. In the future, these names may be ... her 100th birthday. Today, they are among 26 scientists whose work and words ...
(Date:8/29/2018)... PASADENA, Calif. (PRWEB) , ... ... ... (“Fuzionaire Dx”), a radiopharmaceutical company unlocking the full power of positron emission ... in alkali metal catalysis, Fuzionaire Dx is helping clinicians and researchers study ...
(Date:8/26/2018)... ... August 25, 2018 , ... Maire Mayne, an evidence-based ... treated nutraceutical to reduce inflammation and autoimmune disorders and improve overall immune response. ... as inflammation. The following data was reported:,     Over 180% ...
Breaking Biology News(10 mins):
(Date:8/29/2018)... ... 2018 , ... USDM Life Sciences , the leading risk management, technological ... that Manu Vohra will deliver a presentation at the BoxWorks 2018 conference ... for GxP in 30 Days” , When: Thursday, August 30, 1:00-1:50 PM PT, Where: ...
(Date:8/21/2018)... LEXINGTON, Mass. (PRWEB) , ... ... ... Corporation , a software company specializing in medical device compliance and commercialization, ... leveraging the Cockpit® platform. , Written and presented by Dr. Mario Kossmann, ...
(Date:8/17/2018)... ... August 17, 2018 , ... VANCOUVER, British ... Repositories (ISBER) is pleased to announce the release of the Russian translation of ... released in January 2018, is a practice-changing publication aimed at advancing the science ...
(Date:8/9/2018)... ... August 08, 2018 , ... ... expert services platform by combining its deep pharmaceutical compliance and technical expertise ... you meet periodic pharmaceutical GxP training requirements. , Bringing training to ...
Breaking Biology Technology:
Cached News: