Elderly mice yield clues to the process of g...( dysfunction hair loss loss of immune...)

Elderly mice yield clues to the process of growing old

dysfunction, hair loss, loss of immune cells, anemia, and loss of male germ cells that lead to reduced sperm production and infertility.

Intriguingly, the mice develop symptoms of old age, notably gray hair and hair loss, more commonly seen in humans than mice.

Prolla suggests that new studies of mice engineered to have fewer than normal mitochondrial DNA defects or improved mitochondrial function may pave the way for strategies to retard aging. "The idea would be to reduce the level of cell death and improve function. If that pans out, then we can begin to think about pharmaceutical interventions to retard aging by preserving mitochondrial function."

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Contact: Tomas A. Prolla
taprolla@wisc.edu
608-265-5204
University of Wisconsin-Madison
14-Jul-2005

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