Eleven million Euros for...( rowth factors bind to and activate sp...)

rowth factors bind to, and activate, specific receptors on the membrane. The receptor passes the activation signal onto other cellular molecules that transmit it further. The domino effect of this activation cascade propagates and amplifies the signal throughout the cell thereby affecting activation of numerous cellular components. Eventually, the signal reaches the nucleus where it regulates gene expression.

Overall, signalling from growth factors is a highly specific and fine-tuned process. Up until now little has been known on how growth factor signalling is regulated through endocytic pathways, which regulators are involved, how the signal is passed on under different conditions and how the pathways differ from various growth factors.

Endotrack now aims at understanding how signalling from growth factors is regulated by the endocytic pathways and how modulation of these routes affects signalling. The identification of regulators of the different endocytic pathways is important for this process and therefore intracellular endocytic routes of different classes of growth factor complexes will be examined and the specific regulators defined. Endotrack will shed light on growth factor signalling not only in cell culture but also in animal disease model systems to get a clearer picture on how growth factor signalling causes diseases.

Endotrack has started on February 1, 2006 and will continue for four years.

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Contact: Jutta Tatzel
49-351-210-2004
Max-Planck-Gesellschaft
14-Jul-2006

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