HOME >> BIOLOGY >> NEWS
Embryonic stem cells treated with growth factor reverse hemophilia in mice

CHAPEL HILL -- University of North Carolina at Chapel Hill researchers have made a discovery that may have implications for the treatment of liver-based genetic defects such as hemophilia A and B in humans.

Mouse embryonic stem cells treated in culture with a growth factor and then injected into the liver reverse a form of hemophilia in mice analogous to hemophilia B in humans, the new study shows. A report of the study appears in the journal Proceedings of the National Academy of Sciences today (Feb. 15).

The genetically altered mice lack the clotting substance factor IX, which in humans results in the hereditary bleeding disorder known as hemophilia B. This disease, much less common than hemophilia A, affects roughly one of every 35,000 people, primarily males.

Although embryonic stem, or ES, cells can differentiate into most cell types in the body, numerous problems have arisen in translating their potential into therapeutic strategies, the UNC School of Medicine study authors reported.

These problems include poor engraftment, limited function, rejection of engrafted cells by the immune system and teratomas, tumors involving a mixture of tissue not normally found at that site.

The new study used a line of mouse ES cells developed in the laboratory of senior co-author Dr. Oliver Smithies, Excellence professor of pathology and laboratory medicine at UNC.

A member of the National Academy of Sciences, Smithies has won many honors for gene targeting, a technique he pioneered. This technique allows for the development of mice with specific genetic mutations that mimic human illnesses such as hemophilia. In 2001, Smithies received the Albert Lasker Award for Basic Medical Research, often called "America's Nobel."

In the study, ES cells were treated with fibroblast growth factor for seven days prior to injection. As expected, this resulted in ES cells differentiating into early endoderm like precursors, which the researchers name
'"/>

Contact: Leslie H. Lang
llang@med.unc.edu
919-843-9687
University of North Carolina School of Medicine
15-Feb-2005


Page: 1 2 3

Related biology news :

1. Embryonic selection of sex avoids conceiving blind children
2. Embryonic stem cells do better on bumpy nanoscale mattress
3. Embryonic patterning makes the feathers fly
4. AAAS urges US President to sign Embryonic Stem Cell Act
5. Embryonic stem cells accrue genetic changes
6. NIH selects Burnham Institute for Exploratory Center for Human Embryonic Stem Cell Research
7. Embryonic law and order
8. Embryonic stem cells correct congenital heart defect in mouse embryos
9. Newly created cancer stem cells could aid breast cancer research
10. ESF EURYI award winner aims to stop cancer cells reading their own DNA
11. OHSU turns mouse into factory for human liver cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/29/2018)... ... August 28, 2018 , ... Today, Bright Computing , ... In Science Technologies has implemented Bright Cluster Manager at the HudsonAlpha Institute for ... genomics and genetics research institute located in Huntsville, Ala. Its mission is four-fold: ...
(Date:8/26/2018)... YORBA LINDA, Calif. (PRWEB) , ... August 23, ... ... to the potential it has for increased sensitivity and specificity over more commonly ... of the instrumentation and the added burden of development and validation of methods ...
(Date:8/23/2018)... ... August 21, 2018 , ... CRISPR-Cas9 gene editing ... and species for the robust functional interrogation of complex biological processes. Gene editing ... based immunotherapies, the study of the autoimmunity, the understanding of host-pathogen dynamics that ...
Breaking Biology News(10 mins):
(Date:9/22/2018)... WESTMINSTER, Colo. (PRWEB) , ... ... ... Flagship Biosciences are excited to announce a strategic venture. The synergistic combination ... pathology platform provides complimentary and comprehensive biomarker profiling to empower clinical trials ...
(Date:9/22/2018)... (PRWEB) , ... September 20, 2018 , ... ... technologies and development solutions for drugs, biologics and consumer health products, today announced ... Relevant Today: Lipid-Based Drug Delivery in Modern Pharmaceutical Development,”. The one-day event is ...
(Date:9/22/2018)... LINDA, Calif. (PRWEB) , ... ... ... role of distinct cellular phenotypes in tissue function, development, and pathogenesis requires ... while preserving spatial information. , Multiplexed Ion Beam Imaging by Time-Of-Flight ...
(Date:9/15/2018)... ... , ... Next-generation genomic sequencing is transforming what is known about pediatric cancer ... past, the sheer size of genomics data has made sharing across the global scientific ... to advance cures by reducing the technological barriers to data sharing and analysis. Developed ...
Breaking Biology Technology:
Cached News: