HOME >> BIOLOGY >> NEWS
Emory scientists develop new map of genetic variation in human genome

Atlanta -- Emory University scientists have identified and created a map of more than 400,000 insertions and deletions (INDELs) in the human genome that signal a little-explored type of genetic difference among individuals. INDELS are an alternative form of natural genetic variation that differs from the much-studied single nucleotide polymorphisms (SNPs). Both types of variation are likely to have a major impact on humans, including their health and susceptibility to disease.

The INDEL research, led by Scott Devine, PhD, assistant professor of biochemistry at Emory University School of Medicine, has been posted online and will be published in the September issue of the journal Genome Research.

The human genome sequence in our DNA contains three billion base pairs of four chemical building blocks adenine, thymine, cytosine, and guanine (A, T, C, G), strung together in different combinations in long chains within 23 pairs of chromosomes. When the first human genome was being sequenced, it became apparent that additional human genomes would have to be sequenced to identify the places in the genetic code that account for human variation. Scientists now know that humans share about 97-99 percent of the genetic code, and the remaining 1-3 percent dictates individual differences. These naturally occurring differences, called polymorphisms, help explain differences in appearance, susceptibility to diseases, and responses to the environment.

SNPs are differences in single chemical bases in the genome sequence, and INDELs result from the insertion and deletion of small pieces of DNA of varying sizes and types. If the human genome is viewed as a genetic instruction book, then SNPs are analogous to single letter changes in the book, whereas INDELs are equivalent to inserting and deleting words or paragraphs.

Most polymorphism discovery projects have focused on SNPs, resulting in the International HapMap Project a catalog and map
'"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University Health Sciences Center
10-Aug-2006


Page: 1 2 3

Related biology news :

1. New genetic test developed at Emory advances detection and diagnosis of muscular dystrophy
2. Hormones may affect how brain listens, Emory study finds
3. Emory scientists discover unique binding method for essential cellular protein ubiquitin
4. Blood conservation strategies take center stage at Emory University Hospital forum
5. NIH awards Georgia Tech/Emory $11.5 M for nano cardiology research
6. Emory scientist finds different paths lead to similar cognitive abilities
7. Emory scientists find new prostate cancer suppressor gene
8. Emory study finds monarch health tied to migration
9. Emory researchers find more evidence for childrens growth spurts, pain
10. Emory biochemist writes lead essay describing Nobel Prize research on ubiquitin protein
11. Emory study details dolphin brain evolution for the first time

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2017)... , March 30, 2017  On April 6-7, 2017, ... the Genome hackathon at Microsoft,s headquarters in ... competition will focus on developing health and wellness apps ... Hack the Genome is the first hackathon ... The world,s largest companies in the genomics, tech and ...
(Date:3/27/2017)... ROCKVILLE CENTRE, N.Y. , March 27, 2017 ... by Healthcare Information and Management Systems Society (HIMSS) ... Analytics Outpatient EMR Adoption Model sm . In ... top 12% of U.S. hospitals using an electronic ... recognized CHS for its high level of EMR ...
(Date:3/22/2017)... Lithuania , March 21, 2017   ... and object recognition technologies, today announced the release ... kit (SDK), which provides improved facial recognition using ... cameras on a single computer. The new version ... to improve accuracy, and it utilizes a Graphing ...
Breaking Biology News(10 mins):
(Date:5/16/2017)... ... May 16, 2017 , ... Genedata, a leading provider ... User Group Meetings, which will be held in Boston, Cambridge/UK, Shanghai, and ... in screening data analysis and learn about the latest advances in screening technologies ...
(Date:5/16/2017)... ... (PRWEB) May 16, 2017 , ... ... (CAOS), long-standing development partners Invibio Biomaterial Solutions, UK, and China’s Double Medical ... help expand knowledge of the implantation of Double Medical’s Direct Lateral Interbody ...
(Date:5/15/2017)... ... May 15, 2017 , ... ... the clinical skincare brand has today launched its first-ever cross-medium campaign, #StandFirm, with ... shared across digital and social media channels, emphasizing Algenist’s stance on individuality and ...
(Date:5/11/2017)... ... May 11, 2017 , ... Quorum Review IRB , the ... that it has joined SMART IRB , a platform designed to simplify the ... to ease burdens related to multi-site research and serve as a roadmap for institutions ...
Breaking Biology Technology:
Cached News: