HOME >> BIOLOGY >> NEWS
Engineering nerve jumper cables for spinal cord repair in animal model

Researchers at the University of Pennsylvania School of Medicine have created in a rodent model a completely new way to engineer nerve structures, or constructs, in culture. This proof-of-principle research has implications for eventually becoming a new method to repair spinal cord injury in humans. The work appears in the latest issue of Tissue Engineering.

"We have created a three-dimensional neural network, a mini nervous system in culture, which can be transplanted en masse," explains senior author Douglas H. Smith, MD, Professor, Department of Neurosurgery and Director of the Center for Brain Injury and Repair at Penn. Previously, Smith's group showed that they could grow axons by placing neurons from rat dorsal root ganglia (clusters of nerves just outside the spinal cord) on nutrient-filled plastic plates. Axons sprouted from the neurons on each plate and connected with neurons on the other plate. The plates were then slowly pulled apart over a series of days, aided by a precise computer-controlled motor system.

In this study, the neurons were elongated to 10mm over seven days after which they were embedded in a collagen matrix (with growth factors), rolled into a form resembling a jelly roll, and then implanted into a rat model of spinal cord injury.

"That creates what we call a nervous-tissue construct," says Smith. "We have designed a geometrical arrangement that looks similar to the longitudinal arrangement that the spinal cord had before it was damaged. The long bundles of axons span two populations of neurons, and these neuron constructs can grow axons in two directions toward each other and into the host spinal cord at each side. That way they can integrate and connect the 'cables' to the host tissue in order to bridge a spinal cord lesion."

After the four-week study period, the researchers found that the geometry of the construct was maintained and that the neurons at both ends and all the axons spanning these neu
'"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-662-2560
University of Pennsylvania School of Medicine
16-Feb-2006


Page: 1 2

Related biology news :

1. Engineering professor receives prestigious NSF Career Award
2. 4th International Conference on Ethical Issues in Biomedical Engineering
3. AEA, UAlbany College of Nanoscale Science and Engineering to partner on CIRCA 07
4. Engineering the heart piece by piece
5. 2007 Amgen Biochemical Engineering Award
6. Enzyme Engineering XIX
7. Engineering Cell Biology II
8. National Academy of Engineering announces winners of $1M challenge
9. Porous Media and its Applications in Science, Engineering and Industry
10. Biochemical Engineering XV
11. Green Chemical Reactor Engineering -- XI

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2019)... TORONTO (PRWEB) , ... August 14, 2019 , ... Join ... live session on Tuesday, September 10, 2019 at 1pm EDT to learn ... stratification and effective management. , NAFLD is the most common diffuse liver disease, ...
(Date:8/14/2019)... ... August 14, 2019 , ... Gateway Genomics , ... children, announces inclusion in the 38th annual Inc. 500|5000 list of fastest ... To qualify, companies must have been founded and generating revenue by March 31, 2015. ...
(Date:8/14/2019)... ... ... Julie Reck of Veterinary Medical Center of Fort Mill has recently begun providing ... her own geriatric Australian Shepherd, Simon, was treated in June 2019 for osteoarthritis in his ... body was weak, and he struggled to play fetch and other games with his family. ...
Breaking Biology News(10 mins):
(Date:9/17/2019)... ... September 17, 2019 , ... ... in chronic diseases, announces today that the U.S. Patent and Trademark Office (USPTO) ... algorithm to rank drug class recommendations for hypertension treatment. , The patent ...
(Date:9/17/2019)... ... September 16, 2019 , ... A new episode of Advancements ... ET. Check local listings for more information on this program. , The show ... company from Singapore dedicated to developing advanced diagnostic technologies for the masses. Viewers ...
(Date:9/11/2019)... ... September 09, 2019 , ... Suvoda ... randomization and drug supply chain management, today announced its new technology partnership with ... industry. , “The integration between Veeva Vault EDC and our IRT will enable ...
(Date:9/9/2019)... , ... September 09, 2019 , ... Visikol CEO Dr. ... that was focused on how best to characterize 3D cell culture models. The inherent ... they are too thick and opaque to image through and therefore traditional wide-field or ...
Breaking Biology Technology:
Cached News: