HOME >> BIOLOGY >> NEWS
Engineering nerve jumper cables for spinal cord repair in animal model

Researchers at the University of Pennsylvania School of Medicine have created in a rodent model a completely new way to engineer nerve structures, or constructs, in culture. This proof-of-principle research has implications for eventually becoming a new method to repair spinal cord injury in humans. The work appears in the latest issue of Tissue Engineering.

"We have created a three-dimensional neural network, a mini nervous system in culture, which can be transplanted en masse," explains senior author Douglas H. Smith, MD, Professor, Department of Neurosurgery and Director of the Center for Brain Injury and Repair at Penn. Previously, Smith's group showed that they could grow axons by placing neurons from rat dorsal root ganglia (clusters of nerves just outside the spinal cord) on nutrient-filled plastic plates. Axons sprouted from the neurons on each plate and connected with neurons on the other plate. The plates were then slowly pulled apart over a series of days, aided by a precise computer-controlled motor system.

In this study, the neurons were elongated to 10mm over seven days after which they were embedded in a collagen matrix (with growth factors), rolled into a form resembling a jelly roll, and then implanted into a rat model of spinal cord injury.

"That creates what we call a nervous-tissue construct," says Smith. "We have designed a geometrical arrangement that looks similar to the longitudinal arrangement that the spinal cord had before it was damaged. The long bundles of axons span two populations of neurons, and these neuron constructs can grow axons in two directions toward each other and into the host spinal cord at each side. That way they can integrate and connect the 'cables' to the host tissue in order to bridge a spinal cord lesion."

After the four-week study period, the researchers found that the geometry of the construct was maintained and that the neurons at both ends and all the axons spanning these neu
'"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-662-2560
University of Pennsylvania School of Medicine
16-Feb-2006


Page: 1 2

Related biology news :

1. Engineering professor receives prestigious NSF Career Award
2. 4th International Conference on Ethical Issues in Biomedical Engineering
3. AEA, UAlbany College of Nanoscale Science and Engineering to partner on CIRCA 07
4. Engineering the heart piece by piece
5. 2007 Amgen Biochemical Engineering Award
6. Enzyme Engineering XIX
7. Engineering Cell Biology II
8. National Academy of Engineering announces winners of $1M challenge
9. Porous Media and its Applications in Science, Engineering and Industry
10. Biochemical Engineering XV
11. Green Chemical Reactor Engineering -- XI

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/24/2017)... -- The Controller General of Immigration from Maldives Mr. ... have received the prestigious international IAIR Award for the most innovative high ... ... Maldives Immigration Controller ... (small picture on the right) have received the IAIR award for the ...
(Date:3/23/2017)... 23, 2017 Research and Markets has announced ... & Trends - Industry Forecast to 2025" report to their ... The ... CAGR of around 8.8% over the next decade to reach approximately ... the market estimates and forecasts for all the given segments on ...
(Date:3/22/2017)... , March 21, 2017 Vigilant Solutions ... serving law enforcement agencies, announced today the appointment of ... director of public safety business development. Mr. ... enforcement experience, including a focus on the aviation transportation ... most recent position, Mr. Sheridan served as the Aviation ...
Breaking Biology News(10 mins):
(Date:8/21/2017)... Maryland (PRWEB) , ... August 21, 2017 , ... ... partnered with a leading Chinese bio security firm, to bring its proprietary CANARY ... As part of the relationship, the Chinese firm has purchased an undisclosed number ...
(Date:8/21/2017)... ... August 21, 2017 , ... Today Aether announced that Aether and ... a Bill and Melinda Gates Foundation grant, to pursue a 3D ... Foundation, also known as the Gates Foundation, is said to be the largest transparently ...
(Date:8/17/2017)... (PRWEB) , ... August 17, 2017 , ... ... the stock market news outlet had provided a research update on Aytu Bioscience ... administered TRT product. , According to Soulstring, prescription rates for Natesto® have more ...
(Date:8/16/2017)... ... August 16, 2017 , ... ... and Electrospraying line of nanofiber and nanoparticle fabrication instruments from ... lab to fully automated pilot plants and equipment for industrial manufacturing. All ...
Breaking Biology Technology:
Cached News: