HOME >> BIOLOGY >> NEWS
Engineering nerve jumper cables for spinal cord repair in animal model

Researchers at the University of Pennsylvania School of Medicine have created in a rodent model a completely new way to engineer nerve structures, or constructs, in culture. This proof-of-principle research has implications for eventually becoming a new method to repair spinal cord injury in humans. The work appears in the latest issue of Tissue Engineering.

"We have created a three-dimensional neural network, a mini nervous system in culture, which can be transplanted en masse," explains senior author Douglas H. Smith, MD, Professor, Department of Neurosurgery and Director of the Center for Brain Injury and Repair at Penn. Previously, Smith's group showed that they could grow axons by placing neurons from rat dorsal root ganglia (clusters of nerves just outside the spinal cord) on nutrient-filled plastic plates. Axons sprouted from the neurons on each plate and connected with neurons on the other plate. The plates were then slowly pulled apart over a series of days, aided by a precise computer-controlled motor system.

In this study, the neurons were elongated to 10mm over seven days after which they were embedded in a collagen matrix (with growth factors), rolled into a form resembling a jelly roll, and then implanted into a rat model of spinal cord injury.

"That creates what we call a nervous-tissue construct," says Smith. "We have designed a geometrical arrangement that looks similar to the longitudinal arrangement that the spinal cord had before it was damaged. The long bundles of axons span two populations of neurons, and these neuron constructs can grow axons in two directions toward each other and into the host spinal cord at each side. That way they can integrate and connect the 'cables' to the host tissue in order to bridge a spinal cord lesion."

After the four-week study period, the researchers found that the geometry of the construct was maintained and that the neurons at both ends and all the axons spanning these neu
'"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-662-2560
University of Pennsylvania School of Medicine
16-Feb-2006


Page: 1 2

Related biology news :

1. Engineering professor receives prestigious NSF Career Award
2. 4th International Conference on Ethical Issues in Biomedical Engineering
3. AEA, UAlbany College of Nanoscale Science and Engineering to partner on CIRCA 07
4. Engineering the heart piece by piece
5. 2007 Amgen Biochemical Engineering Award
6. Enzyme Engineering XIX
7. Engineering Cell Biology II
8. National Academy of Engineering announces winners of $1M challenge
9. Porous Media and its Applications in Science, Engineering and Industry
10. Biochemical Engineering XV
11. Green Chemical Reactor Engineering -- XI

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... April 13, 2017 According to a new market ... Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, ... Market is expected to grow from USD 14.30 Billion in 2017 to ... of 17.3%. ... MarketsandMarkets Logo ...
(Date:4/11/2017)... N.Y. , April 11, 2017 ... fingerprints, but researchers at the New York University ... College of Engineering have found that partial similarities ... security systems used in mobile phones and other ... thought. The vulnerability lies in the ...
(Date:4/5/2017)... April 5, 2017  The Allen Institute for Cell ... Explorer: a one-of-a-kind portal and dynamic digital window into ... data, the first application of deep learning to create ... cell lines and a growing suite of powerful tools. ... these and future publicly available resources created and shared ...
Breaking Biology News(10 mins):
(Date:4/28/2017)... ... April 28, 2017 , ... While things have been quiet for EcoloCap ... and provide a new outlook for the future. As a continued effort to ... with the retirement of Mr. Siegel as CEO. With the new adjustments in management, ...
(Date:4/27/2017)... and RESEARCH TRIANGLE PARK, N.C. , ... UTHR ) today announced that its Board ... million of the company,s common stock. This program will ... 31, 2017. Purchases may be made in the open ... from time to time as determined by United Therapeutics, ...
(Date:4/27/2017)... ... 2017 , ... Proscia Inc., a data ... has the potential to eliminate subjectivity in the detection and classification of breast ... of the 2017 ISBI CAMELYON Digital Pathology Challenge, organized by the ...
(Date:4/27/2017)... ... April 27, 2017 , ... This month ... consent (eConsent) solution that simplifies research studies, accelerates study startup, and improves participant ... Q Consent™ is the first and only IRB-integrated eConsent solution . , ...
Breaking Biology Technology:
Cached News: