Enhanced environment restores memory in mice with neurode...( s tested whether a class of drugs that ...)

s tested whether a class of drugs that preserves histone acetylation, called histone deacetylases inhibitors, could affect learning and memory in the p25-induced mice. "In those studies, we found that using drugs to increase histone acetylation artificially produced an effect very similar to that observed in environmental enrichment," said Tsai. "This leads us to believe that further studies of ways to target chromatin remodeling could offer a treatment for Alzheimer's and other forms of dementia," she said. Tsai's group is now investigating the molecular mechanism by which such drugs work and which specific drug targets might be most effective at enhancing learning and memory.

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Contact: Jennifer Michalowski
michalow@hhmi.org
301-215-8576
Howard Hughes Medical Institute
29-Apr-2007

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