HOME >> BIOLOGY >> NEWS
Environment and exercise may affect research results, UA study shows

A recently completed study at The University of Arizona may have implications for the thousands of scientists worldwide who use knockout mice in their research.

In the study, Knockout Mice: Is it Just Genetics? Effects of Enriched Housing on Fibulin-4+/- Mice, lead researcher Ann Baldwin, PhD, suggests that environmental factors may play a large part in research findings that investigators assume are due simply to genetic differences. Further, the study research indicates that appropriate environments may counteract the effects of some genetic deficiencies.

The knockout technique is used widely by researchers to aid in understanding physiological functions at the cellular and molecular level. Essentially, it eliminates one or both copies of a gene that produces a specific protein or enzyme.

Dr. Baldwin, a professor of physiology and psychology at the UA College of Medicine, developed a study focusing on mice with only one copy of a gene that encodes for an extracellular matrix protein, fibulin-4. The extracellular matrix, often referred to as connective tissue, supports tissue cells. Fibulin-4 is localized in the aortic media and is essential for maintaining arterial integrity. Dr. Baldwin wanted to determine whether these mice, known as heterozygous fibulin-4 knockout mice, showed arterial defects on a microscopic scale, although outwardly they appeared to be normal.

Using high-powered electron microscopy, she found small areas of disorganized tissue, referred to as gaps, in the aortas of the heterozygous fibulin-4 knockout mice. The number of gaps found in the knockout mice was approximately 100 times greater than those found in the control, or wild-type, mice.

After preliminary experiments were performed, a second purpose for the study developed, and the researchers set about investigating a hypothesis that the pathologies they observed would be ameliorated by enriched housing conditions.

In the initi
'"/>

Contact: Dr. Ann Baldwin
abaldwin@email.arizona.edu
520-626-6264
Public Library of Science
20-Feb-2007


Page: 1 2 3

Related biology news :

1. Investigating Life in Extreme Environments report gives hints on facts of life
2. Winner of Tyler Environmental Prize announced
3. Environments resilient in the face of hurricanes, but questions remain, says journal special issue
4. Environmental markets theme for February meeting in Houston
5. USGS at Society of Environmental Toxicology and Chemistry
6. Environmental toxicology experts to convene at Penn symposium
7. German Environment Prize awarded to Ernst-Detlef Schulze
8. Symposium Environmental Change in Siberia -- Insights From Earth Observation and Modeling
9. Environmental toxins may cause bodys defenses to worsen lung disease
10. Global Environmental Change: Regional Challenges
11. Comparative Environmental Politics

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/28/2020)... ... June 25, 2020 , ... In an upcoming episode ... in accelerated Point of Care Testing solutions (POCT). Check local listings for more info. ... at medical offices and are shipped to labs throughout the country. Results are then ...
(Date:6/23/2020)... MILTON KEYNES, England (PRWEB) , ... June 23, ... ... operations in Africa supporting sustainable healthcare, and Renovagen Ltd, a UK supplier and ... rapid response project to support testing operations in the fight against the COVID-19 ...
(Date:6/23/2020)... ... 2020 , ... In its June 22 online post, business and technology news ... M.D., Ph.D., founder and director of stem cell biotechnology company Asymmetrex . Superb ... that starting July 5 it would begin offering free tissue stem cell counting ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... 29, 2020 , ... Anomet Products has introduced new custom ... use with CRM, neurostimulation, vascular, and related devices. , Anomet Medical Clad ... performance, and cost criteria; especially where solid wire is limited. Typical configurations for ...
(Date:7/22/2020)... ... ... Join experts from Reed Tech , Gary Saner, Sr. Manager, Information Solutions ... live webinar on Thursday, August 13, 2020 at 11am EDT (4pm BST/UK). , ... for medical devices, the NMPA has departments dealing with medical device registration (pre-market approvals) ...
(Date:7/10/2020)... , ... July 08, 2020 , ... ... and products, announces a significant expansion of laboratory operations through its COVID-19 ... agencies implementing testing programs. , Bode-CARES provides a turnkey solution ...
(Date:7/7/2020)... ... July 06, 2020 , ... Bio-IT World ... Eli Lilly, Bristol-Myers Squibb, the University of Chicago, Massachusetts General Hospital, Mission: Cure, ... an elite awards program, highlighting outstanding examples of how technology innovations and strategic ...
Breaking Biology Technology:
Cached News: