HOME >> BIOLOGY >> NEWS
Environmental triggers may promote human genetic variation

oxoG was remarkably similar in different individuals.

"We suggest that 8-oxoG accumulation in a particular region of a chromosome causes meiotic recombination," says Nakabeppu. "Our theory is supported by studies showing that enzymes involved in the repair of oxidative DNA damage can also induce homologous recombination. These enzymes are highly expressed in the ovary and testis, where meiotic recombination normally occurs. Furthermore, meiotic recombination rates in females are significantly higher than in males, probably because oocytes are exposed to oxidative stress for longer periods of time than are spermatocytes."

The uneven distribution of SNPs across the human genome has been documented for some time, but the causes of these nucleobase substitutions and the factors determining their distribution are largely unknown. Nakabeppu, therefore, also suggests that 8-oxoG, due to its mutagenic potential, may contribute to the formation of SNPs.

But why the clustering of 8-oxoG?

"The factors determining the distribution of 8-oxoG are still unknown," explains Nakabeppu. "One can certainly argue that there must be another factor that coincidentally increases the recombination rate or the formation of SNPs in addition to the accumulation of 8-oxoG in a particular region of the chromosome. The local structures of chromosomes and their replication or transcription might help to determine the distribution of 8-oxoG, but further analysis is required to fully understand the mechanistic relationship between 8-oxoG, recombination, and mutagenesis."


'"/>

Contact: Maria Smit
smit@cshl.edu
516-422-4013
Cold Spring Harbor Laboratory
30-Apr-2006


Page: 1 2

Related biology news :

1. Winner of Tyler Environmental Prize announced
2. Environmental markets theme for February meeting in Houston
3. USGS at Society of Environmental Toxicology and Chemistry
4. Environmental toxicology experts to convene at Penn symposium
5. Symposium Environmental Change in Siberia -- Insights From Earth Observation and Modeling
6. Environmental toxins may cause bodys defenses to worsen lung disease
7. Global Environmental Change: Regional Challenges
8. Comparative Environmental Politics
9. Penn receives $4 million to establish a Center of Excellence in Environmental Toxicology
10. Environmental tobacco smoke linked to behavior problems in children and pre-teens
11. Environmental effects on genetic adaptation and population dynamics

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/3/2020)... ... August 03, 2020 , ... Accumen Inc. is helping ... equipment manufacturer, Spectrum Solutions, to provide COVID-19 saliva testing kits nationally. , ... for more than 10 years. Early in the COVID-19 crisis, we identified supply ...
(Date:7/22/2020)... Calif. (PRWEB) , ... July 21, 2020 , ... ... driving digital transformation and innovation in technology and compliance, announces a new solution ... device companies must ensure every layer of their technology stack complies with FDA ...
(Date:7/10/2020)... ... July 08, 2020 , ... Overcoming Comparability Issues ... An FDAnews Webinar, Wednesday, July 22, 2020 • 1:30 p.m.-3:00 p.m. EDT, ... the most effective way to complete one? Will the study comply with all ...
Breaking Biology News(10 mins):
(Date:8/15/2020)... ... August 13, 2020 , ... Inc. magazine today revealed ... prestigious ranking of the nation’s fastest-growing private companies. The list represents a unique ... independent small businesses. Intuit, Zappos, Under Armour, Microsoft, Patagonia, and many other well-known ...
(Date:8/12/2020)... ... August 11, 2020 , ... ... making available for free its new white paper – Simulated Transport Methodologies. ... into today’s biologics licensing application (BLA). In response, Modality Solutions shares an ...
(Date:8/7/2020)... ... 06, 2020 , ... VGXI, a highly regarded CDMO supporting ... purchase of greenfield for a new, expanded manufacturing facility. The site is located ... the initial acquisition, with an option to purchase an additional 21 acres for ...
(Date:8/3/2020)... ... ... Introducing Ardent Animal Health – MediVet Biologics rebrands company and positions its platform ... Biologics since its formation in 2016, the company is relaunching itself under the Ardent ... its base of innovative therapies for osteoarthritis and cancer. , ...
Breaking Biology Technology:
Cached News: