HOME >> BIOLOGY >> NEWS
Enzyme action creates protein linked to Alzheimer's disease

DALLAS Aug. 11, 2005 Researchers at UT Southwestern Medical Center have defined a key step in the production of beta-amyloid, a short protein that is thought to be responsible for the development of Alzheimer's disease. Understanding this step may aid in the discovery of drugs that could help block the disease from developing.

In Alzheimer's disease, too much beta-amyloid is produced by an enzyme that has many other essential roles. As a result, simply blocking the whole enzyme knocks out many of its other functions which is fatal to the organism.

Using cultured human and mouse cells, as well as test-tube assays, UT Southwestern researchers singled out how just one portion of the enzyme, a protein called nicastrin, is involved in the pathway that produces beta-amyloid, thereby leading to Alzheimer's disease. They hope next to work on ways to specifically block nicastrin. The study appears in the August 12 issue of the journal Cell.

"The work provides an attractive potential strategy for developing treatment for Alzheimer's disease," said Dr. Gang Yu, assistant professor in the Center for Basic Neuroscience and of cell biology and senior author of the study. The research uncovered an "unprecedented mechanism of biochemistry," Dr. Yu said.

Nicastrin is a large protein that is a component of an enzyme called gamma-secretase, which is lodged in the cell's membrane. When it is at the cell surface, nicastrin sticks out into the area outside the cell. It has been thought to play a key role in the creation of a protein called amyloid-beta the prime suspect for the damage Alzheimer's does to the brain but the exact mechanism was unknown.

Dr. Yu and his colleagues found that nicastrin binds to several proteins lodged in the cell's membrane, including one called amyloid precursor protein, or APP. Nicastrin then guides membrane-bound proteins to the active area of gamma-secretase, which then splits the proteins. APP, for example, is chopped into
'"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
11-Aug-2005


Page: 1 2

Related biology news :

1. Enzyme discovery sheds light on vitamin D
2. Enzyme delivered in smaller package protects cells from radiation damage
3. Enzyme Engineering XIX
4. Enzyme inhibitor produces stable disease in patients with advanced solid cell cancers
5. Enzyme shreds Alzheimers protein
6. Enzyme defect leads to hyperinsulinism
7. Eat less, weigh more? Enzyme makes lean mice susceptible to dietary fat
8. Enzyme crystal structure reveals unexpected genome repair functions
9. Enzyme inhibitors block replication of SARS virus
10. Enzyme may be target for new anti-inflammatory compounds
11. Enzyme deficiency may contribute to liver cancer, Mount Sinai research indicates

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Enzyme action creates protein linked Alzheimer disease

(Date:10/31/2014)... WCS study confirms that endangered musk deer still live ... sighting, Species targeted by poachers: Musk deer scent glands ... the October issue of the journal Oryx ... 60 years after its last confirmed sighting, a strange ... forested slopes of northeast Afghanistan according to a research ...
(Date:10/31/2014)... Planting trees and creating green space in cities is good ... ensure biodiversity in built environments, a University of Iowa study ... in an urban area in Iowa, and recorded the abundance ... while there were plenty of the trees, black cherry and ... insects, in this case fruit flies that feed on the ...
(Date:10/31/2014)... team have been studying the behavior of approximately ... for years. They observed that ravens slowly build ... playing. However, they also observed that these affiliative ... Although in about 50 % of the cases ... two affiliating ravens, intervening can be potentially risky ...
Breaking Biology News(10 mins):Strange, fanged deer persists in Afghanistan 2Green spaces don't ensure biodiversity in urban areas 2
(Date:10/31/2014)... 2014 Two separate delegations of ... by Charm Sciences at its Andover, Massachusetts facility ... the US, the participants discussed international systems for ... and process verification, and received hands-on technical training ... the first visit to the United States for ...
(Date:10/31/2014)... The report "Dairy Alternative (Beverage) ... Flavored, Sweetened, Unsweetened), Channel (Supermarket, Health Store, Pharmacy, ... Forecast to 2018," defines and segments the dairy ... of revenue and volume for plant-based dairy alternative ... reach $14 Billion by 2018 with the Asia-Pacific ...
(Date:10/31/2014)... , Oct. 31, 2014  Tavistock Development Co. ... Tavistock Group, celebrated the groundbreaking of the GuideWell ... The 92,000-square-foot, three-story facility is ... Florida designed specifically for life sciences, ... heart of the 650-acre Lake Nona Medical City, ...
(Date:10/30/2014)...  Ardelyx, Inc. (NASDAQ: ARDX ), ... and metabolic diseases, today announced that it will ... November 6, 2014. Following the announcement, the Ardelyx ... and webcast at 4:30pm ET to review the ... The live webcast can be accessed ...
Breaking Biology Technology:Charm Sciences Hosts Executives from Latin America for Dairy Safety Executive Seminar 2Dairy Alternative Beverage Market Projected to Reach $14 Billion by 2018 - Report by MarketsandMarkets 2Dairy Alternative Beverage Market Projected to Reach $14 Billion by 2018 - Report by MarketsandMarkets 3Dairy Alternative Beverage Market Projected to Reach $14 Billion by 2018 - Report by MarketsandMarkets 4GuideWell Innovation Center Groundbreaking Hosted by Tavistock Development Company at Lake Nona Medical City 2GuideWell Innovation Center Groundbreaking Hosted by Tavistock Development Company at Lake Nona Medical City 3Ardelyx to Report Third Quarter 2014 Financial Results on November 6, 2014 2
Cached News: