HOME >> BIOLOGY >> NEWS
Enzyme action creates protein linked to Alzheimer's disease

two parts: amyloid-beta, which is then shipped to the outside of the cell, and another part that remains inside. Amyloid-beta forms the plaques seen in brains afflicted with Alzheimer's.

"Actually, it's quite a simple mechanism," Dr. Yu said. "Hopefully, we can screen for Alzheimer's protein compounds that can block this process and find the exact pathways and how it can be regulated in Alzheimer's disease."

Now that nicastrin's function has been ascertained, it opens a way to block just the splitting of APP, leaving all the enzyme's other functions intact. For instance, it may be possible to generate chemical compounds that specifically prevent nicastrin from latching on to APP. If APP doesn't attach to nicastrin, APP remains intact and harmless. Meanwhile, nicastrin would be free to bind all the other essential proteins that it works on.

"We want to find a particular way to block the recognition of APP but not the others," Dr. Yu said.


'"/>

Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
11-Aug-2005


Page: 1 2

Related biology news :

1. Enzyme discovery sheds light on vitamin D
2. Enzyme delivered in smaller package protects cells from radiation damage
3. Enzyme Engineering XIX
4. Enzyme inhibitor produces stable disease in patients with advanced solid cell cancers
5. Enzyme shreds Alzheimers protein
6. Enzyme defect leads to hyperinsulinism
7. Eat less, weigh more? Enzyme makes lean mice susceptible to dietary fat
8. Enzyme crystal structure reveals unexpected genome repair functions
9. Enzyme inhibitors block replication of SARS virus
10. Enzyme may be target for new anti-inflammatory compounds
11. Enzyme deficiency may contribute to liver cancer, Mount Sinai research indicates

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/17/2018)... ... , ... With increasing safety requirements, and time and financial pressure, the development ... To be successful in such a competitive environment, it is more important than ever ... needed to develop a new drug or to execute fundamental research. , In ...
(Date:8/15/2018)... ... August 15, 2018 , ... The Florida Chiropractic Association’s National Meeting ... Doctors from around the U.S. will gain firsthand insights into the new laser’s ... completed another successful clinical trial that has resulted in the granting of an ...
(Date:8/14/2018)... ... August 13, 2018 , ... Castle Dental® has partnered ... office on South Lamar Blvd. to provide free dental services for underinsured, low-income ... include x-rays and exams, fillings , extractions , cleanings ...
Breaking Biology News(10 mins):
(Date:7/31/2018)... , ... July 31, 2018 , ... ... for 65 years, announces the launch of their new website. The new website ... experience throughout the site. Mahoney partnered with Proceed Innovative to build a website ...
(Date:7/25/2018)... ... July 25, 2018 , ... ... energy treated proprietary nutraceutical to combat inflammation and autoimmune disorders. , The ... function response. The following data was reported:, Over ...
(Date:7/25/2018)... ... July 25, 2018 , ... John McDonald, CEO ... board of the Indiana India Business Council (IIBC), an advocacy group to strengthen ... current board of directors, McDonald joins an impressive roster of local and national ...
(Date:7/24/2018)... ... July 24, 2018 , ... On August 6, ... SmartTRAK platform. Not just a pretty face, SmartTRAK 3.0’s latest improvements were ... SmartTRAK is the world’s first online and real-time data portal that specializes in ...
Breaking Biology Technology:
Cached News: