HOME >> BIOLOGY >> NEWS
Enzyme deficiency may contribute to liver cancer, Mount Sinai research indicates

(Toronto, Ontario, July 27, 2005) Primary liver cancer is much more likely to take root when a naturally occurring enzyme is in short supply, a team of researchers has found at Mount Sinai Hospital's Samuel Lunenfeld Research Institute.

Using a knockout mouse model, the team has found that the likelihood of hepatoma, or primary liver cancer, increases substantially when half the normal amount of an enzyme called Plk4 is present. Furthermore, 60 per cent of patients with hepatoma were missing one copy of the Plk4 gene in their cancers. The genetic basis for hepatoma has not previously been extensively explored.

The study is published today in the August edition of the prestigious science journal, Nature Genetics.

"Our study indicates that loss of one copy of Plk4 is a major risk factor for primary liver cancer," says Dr. Carol Swallow, a surgical oncologist at Mount Sinai Hospital and an Associate Professor of Surgery at University of Toronto.

"This represents a major advance in our understanding of hepatoma at a molecular level and provides insight into who may be predisposed to this type of cancer genetically."

Dr. Swallow and her co-investigators, Dr. Jim Dennis, Senior Investigator at the SLRI, and Mike Ko, a PhD candidate at the University of Toronto, believe that this finding has important implications for screening and early detection.

The American Cancer Society estimates that there will be 667,000 new cases of liver cancer worldwide in 2005, with 83 per cent of them occurring in developing countries, particularly in Southeast Asia. The disease is also more prevalent in men than it is in women.

"Unlike many common cancers, the incidence of hepatoma is increasing in both developed and developing countries," said Dr. Swallow.


'"/>

Contact: Emily Hanft
416-586-3161
University of Toronto
27-Jul-2005


Page: 1

Related biology news :

1. Enzyme discovery sheds light on vitamin D
2. Enzyme delivered in smaller package protects cells from radiation damage
3. Enzyme Engineering XIX
4. Enzyme inhibitor produces stable disease in patients with advanced solid cell cancers
5. Enzyme shreds Alzheimers protein
6. Enzyme defect leads to hyperinsulinism
7. Eat less, weigh more? Enzyme makes lean mice susceptible to dietary fat
8. Enzyme crystal structure reveals unexpected genome repair functions
9. Enzyme inhibitors block replication of SARS virus
10. Enzyme may be target for new anti-inflammatory compounds
11. Enzyme action creates protein linked to Alzheimers disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/5/2018)... ... October 04, 2018 , ... ... of Illinois Extension and Monroe County Economic Development Corporation (EDC), has been ... of Food and Agriculture (NIFA) Non-Land Grant College of Agriculture (NLGCA) Capacity-Building ...
(Date:10/3/2018)... ... October 03, 2018 , ... Fit4D, a leading ... of healthcare visionary, Jimmy Lee, as Strategic Advisor to the company’s board. Mr. ... industry experience. As a Senior Executive at Anthem, he had P&L accountability for ...
(Date:10/2/2018)... ... 02, 2018 , ... Through this webinar, sponsored by Molecular Devices , ... learn the role of calcium kinetics in cardiac safety testing. The speakers for this ... Biography; and Tsang Wai Lam, an assay development scientist at PPSC. , They will ...
Breaking Biology News(10 mins):
(Date:10/17/2018)... ... October 17, 2018 , ... Dr. ... his associate, Dr. Michael Kang, are offering current and new patients the opportunity ... thanks to the emerging, proven treatment technology known as Piezosurgery® . As ...
(Date:10/16/2018)... ... 2018 , ... Infinity Healing Center, along with sixteen other ... that effectively treats pain, reduces the need for opioids, and lowers healthcare costs. ... photobiomodulation (PBM) has been effective for the treatment of medical conditions like Lyme, ...
(Date:10/11/2018)... ... October 10, 2018 , ... ... announces the appointment of Wendy Nelson, PhD, as its new CEO. , Dr. ... experience in the biotech industry. Most recently, Dr. Nelson was VP of ...
(Date:10/5/2018)... CITY, Calif. (PRWEB) , ... October 04, 2018 ... ... infectious disease diagnostics with genomics, along with Duke University, announced today at IDWeek™ ... non-invasive blood test that detects pathogen DNA in plasma, accurately identified causative pathogens ...
Breaking Biology Technology:
Cached News: