HOME >> BIOLOGY >> NEWS
Enzyme discovery sheds light on vitamin D

KINGSTON, Ont. Surprising findings by Queens University researchers have shed new light on how the sunshine vitamin D increasingly used to treat and prevent cancer and other diseases is broken down by our bodies.

The effectiveness of vitamin D therapy is partly dependent on how quickly it will be broken down, says Biochemistry Professor Glenville Jones, an expert in the field of vitamin D metabolism. By studying the enzyme responsible for breaking down the vitamin, we hope to develop a way to prevent this from happening by blocking that response.

First observed in Dr. Joness lab by undergraduate Biochemistry student Brendan OLeary, the discovery reveals that changing a single amino acid in the hydroxylase enzyme will cause it to take a completely different pathway. Although scientists have known for 25 years that the enzyme is capable of taking two different pathways, until now they could not explain why this occurs.

The teams findings are published on-line in the journal Proceedings of the National Academy of Sciences (PNAS). Other members include: research associate David Prosser, PhD student Martin Kaufmann, and research technician Valarie Byford.

Earlier study of the enzyme had shown that its pathway pattern is species specific. Some species, including humans and rats, favour one pathway, while others most notably the opossum favour the other pathway.

Using a technique called liquid chromatography mass spectrometry, the researchers studied cells from animals in both categories. They changed the human enzyme in certain key places to see if this would affect its pathway pattern.

Surprisingly, they discovered that altering a single amino acid completely changes the enzyme from a human pattern to an opossum pattern. This change can be flicked back and forth like a light switch, says Dr. Jones, adding: Its remarkable. In biochemistry you rarely see that kind of predictive work from modeling mol
'"/>

Contact: Nancy Dorrance
nancy.dorrance@queensu.ca
613-533-2869
Queen's University
24-Jul-2007


Page: 1 2

Related biology news :

1. Enzyme delivered in smaller package protects cells from radiation damage
2. Enzyme Engineering XIX
3. Enzyme inhibitor produces stable disease in patients with advanced solid cell cancers
4. Enzyme shreds Alzheimers protein
5. Enzyme defect leads to hyperinsulinism
6. Eat less, weigh more? Enzyme makes lean mice susceptible to dietary fat
7. Enzyme crystal structure reveals unexpected genome repair functions
8. Enzyme inhibitors block replication of SARS virus
9. Enzyme may be target for new anti-inflammatory compounds
10. Enzyme action creates protein linked to Alzheimers disease
11. Enzyme deficiency may contribute to liver cancer, Mount Sinai research indicates

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... -- The Allen Institute for Cell Science today announces the ... and dynamic digital window into the human cell. The ... of deep learning to create predictive models of cell ... growing suite of powerful tools. The Allen Cell Explorer ... available resources created and shared by the Allen Institute ...
(Date:4/3/2017)... 2017  Data captured by IsoCode, IsoPlexis ... a statistically significant association between the potency ... and objective response of cancer patients post-treatment. ... whether cancer patients will respond to CAR-T ... as to improve both pre-infusion potency testing and ...
(Date:3/29/2017)... March 29, 2017  higi, the health IT company ... North America , today announced a Series ... acquisition of EveryMove. The new investment and acquisition accelerates ... tools to transform population health activities through the collection ... higi collects and secures data today on ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... (PRWEB) , ... October 11, 2017 , ... ... compared the implantation and pregnancy rates in frozen and fresh in vitro ... of progesterone and maternal age to IVF success. , After comparing the results ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... conjugate (ADC) therapeutics, today confirmed licensing rights that give it exclusive global ... technology developed in collaboration with Children’s Hospital Los Angeles (CHLA). Additionally, ...
(Date:10/10/2017)... 2017 International research firm Parks Associates announced today ... the TMA 2017 Annual Meeting , October 11 in ... home security market and how smart safety and security products impact the ... Parks Associates: Smart Home Devices: ... "The residential security market has experienced ...
(Date:10/10/2017)... ... October 10, 2017 , ... The Pittcon Program Committee ... honoring scientists who have made outstanding contributions to analytical chemistry and applied ... the world’s leading conference and exposition for laboratory science, which will be held ...
Breaking Biology Technology:
Cached News: