HOME >> BIOLOGY >> NEWS
Enzyme inhibitors block replication of SARS virus

ve been looking at other Liponavir-related compounds for similar blocking effects. During these experiments, they found that a group of catalyzing agents used to help promote chemical reactions in the laboratory were actually more powerful in blocking the SARS protease than either the Lopinavir or any of the target compounds.

These organic compounds are called benzotriazole esters. The esters entered the SARS protease site, formed an intermediary compound, then inactivated the SARS enzyme. The findings were confirmed using mass spectrometry analysis of the enzyme intermediary.

"These benzotriazole esters are relatively stable and act as suicide inhibitors," Wong said. "They block the enzyme, are transformed through a co-valent bond, and are unable to get out."

Wong said the findings published today provide better insight into the mode of action of the enzyme, which may lead to development of a drug against SARS. The findings were made by using rapid drug discovery techniques developed in the Wong lab to screen large numbers of weak enzyme inhibitors, and then attaching additional compounds to look for stronger reactions.

Research Associate Chung-Yi Wu, a member of the Wong lab, is the paper's lead author. He said the finding was unexpected.

"We wanted to improve Liponavir activity," Wu said. "But we found this very surprising and serendipitous result."


'"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
28-Mar-2006


Page: 1 2

Related biology news :

1. Enzyme discovery sheds light on vitamin D
2. Enzyme delivered in smaller package protects cells from radiation damage
3. Enzyme Engineering XIX
4. Enzyme inhibitor produces stable disease in patients with advanced solid cell cancers
5. Enzyme shreds Alzheimers protein
6. Enzyme defect leads to hyperinsulinism
7. Eat less, weigh more? Enzyme makes lean mice susceptible to dietary fat
8. Enzyme crystal structure reveals unexpected genome repair functions
9. Enzyme may be target for new anti-inflammatory compounds
10. Enzyme action creates protein linked to Alzheimers disease
11. Enzyme deficiency may contribute to liver cancer, Mount Sinai research indicates

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2017)... March 30, 2017  On April 6-7, 2017, Sequencing.com ... Genome hackathon at Microsoft,s headquarters in ... will focus on developing health and wellness apps that ... Hack the Genome is the first hackathon for ... world,s largest companies in the genomics, tech and health ...
(Date:3/30/2017)... March 30, 2017 Trends, opportunities and forecast ... behavioral), by technology (fingerprint, AFIS, iris recognition, facial recognition, ... others), by end use industry (government and law enforcement, ... and banking, and others), and by region ( ... Asia Pacific , and the Rest ...
(Date:3/28/2017)... India , March 28, 2017 ... IP, Biometrics), Hardware (Camera, Monitors, Servers, Storage Devices), Software ... Vertical, and Region - Global Forecast to 2022", published ... Billion in 2016 and is projected to reach USD ... between 2017 and 2022. The base year considered for ...
Breaking Biology News(10 mins):
(Date:7/18/2017)... ... July 18, 2017 , ... Genedata, ... a leading science and technology company, has implemented Genedata Biologics ™ to ... areas of Oncology, Immunology, and Neurodegenerative Diseases. , The need to systematically evaluate ...
(Date:7/17/2017)... ... , ... Whitehouse Laboratories is excited to announce that it ... of ISO 80369 standard test procedures. The ISO 80369 series of eight test ... With this recent expansion, Whitehouse Labs becomes one of the only facilities in ...
(Date:7/17/2017)... ... July 17, 2017 , ... Panitch Schwarze ... participated in the BiG (Biomedical Innovation Group) annual meeting in China. , This ... (chimeric antigen receptor T-cell) therapy, a rapidly developing highly personalized anti-cancer technology that ...
(Date:7/15/2017)... , ... July 15, 2017 , ... Cuvette ... years. During this time, the people at FFS have learned that their biggest ... engineers at FFS are able to launch new products to meet the changing needs ...
Breaking Biology Technology:
Cached News: