Kasturi Haldar and col leagues from Northwestern University Medical School, Chicago, investigated a protein in red blood cells (erythrocyte guanine nucleotide regulatory protein Gs) as a novel antimalarial target. They showed that a commonly used antihypertensive drug, propranolol, decreased Gs activity in red blood cells and inhibited blood-stage malarial parasite growth, as did other drugs of the same class. When used in combination with existing antimalarials in cell culture, propranolol reduced the dose of existing antimalarial drugs required to treat animal models of malarial infection. Erythrocyte G may therefore be a novel antimalarial target; in addition, drugs antagonising erythrocyte Gs could be used in combination therapies with existing antimalarial drugs.
Citation: Murphy SC, Harrison T, Hamm HE, Lomasney JW, Mohandas N, et al. (2006) Erythrocyte G protein as a novel target for malarial chemotherapy. PLoS Med 3(12): e528.
PLEASE ADD THE LINK TO THE PUBLISHE D ARTICLE IN ONLINE VERSIONS OF YOU R REPORT:
http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0030528
PRESS-ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-03-12-haldar.pdf
Related image for press use: http://www.plos.org/press/plme-03-12-haldar.jpg
- Caption: Erythrocyte G protein signaling is needed for intracellular malarial parasite proliferation and thus may present a novel antimalarial target (Photographer: Sean C. Murphy)
CONTACTS:
Kasturi Haldar
Northwestern University Medical School
Department of Pathology and Microbiology-Immunology
Ward Bldg. 3rd Floor Rm 220
303 E. Chicago Ave
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Contact: Andrew Hyde
press@plos.org
44-122-346-3330
Public Library of Science
25-Dec-2006
