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Essential genes for embryogenesis uncovered in major mouse mutagenesis project

g their data with estimates from previous studies, the researchers predicted that between 13.7% and 19% of all mouse genes are necessary for embryonic viability. In comparison, research on other organisms has indicated that 6-10% of zebrafish genes and 7% of C. elegans genes are required for prenatal survival. "The higher percentage of embryonic lethal genes in mice may reflect an inherently more complex or sensitive process of development," report the scientists.

The project included major contributions from Schimenti's collaborators at The University of Pennsylvania School of Medicine (Philadelphia, PA) and The Jackson Laboratory (Bar Harbor, ME), where the study was initiated.


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Contact: Maria A. Smit
smit@cshl.edu
516-422-4013
Cold Spring Harbor Laboratory
14-Jul-2005


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