HOME >> BIOLOGY >> NEWS
Evolutionary conservation of a mechanism of longevity from worms to mammals

Though the study of aging in the nematode model organism C. elegans has provided much insight into this complex process, it is not yet clear whether genes involved in aging in the worm have a similar role in mammals. In a recent study, Dr. Hekimi and colleagues of McGill University (Canada) report that inactivation of the gene mclk1, the murine ortholog of the C. elegans gene clk-1, results in increased cellular fitness and prolonged lifespan in mice.

The gene clk-1 in the worm, as well as mclk1 in mice, encodes an enzyme necessary for the biosynhesis of ubiquinone, an essential cofactor in numerous redox reactions such as mitochondrial respiration. Though lack of the mclk1 gene results in embryonic lethality, the authors were able to study mclk1-/- embryonic stem (ES) cells and show that they are resistant to oxidative stress and exhibit reduced DNA damage when compared to ES cells in which this gene is active.

Because these findings would predict that reduced expression of the mclk1 gene would result in longevity, the authors compared the lifespan of mice heterozygous for mclk1 with their wild-type counterparts. A predicted, mclk1+/- mice displayed a substantial increase in lifespan in three different genetic backgrounds tested. Moreover, when the livers of these mice where analyzed, the authors found that a subset of hepatocytes exhibited loss of heterozygosity (effectively becoming mclk1-/- cells) and had undergone clonal expansion. The authors suggest that these mclk null cells were able to out-compete mclk1+/- hepatocytes, suggesting that resistance to oxidative stress upon loss of mclk1 provides a growth advantage.

Though the aging process of different organisms will most likely differ due to different physiologies and environments, Dr. Hekimi summarizes the relevance of their findings by concluding that "the longevity-promoting effect of reducing clk-1/mclk1 activity that was initially observed in C. elegans is conserved in
'"/>

Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
3-Oct-2005


Page: 1 2

Related biology news :

1. Evolutionary relevance of retinoic acid-induced craniofacial malformations
2. Evolutionary Medicine Meeting will advance a new scientific discipline
3. Evolutionary influences on proteins
4. Phyloinformatics Hackathon at the National Evolutionary Synthesis Center
5. Dont move a muscle: Evolutionary insight into myogenesis
6. Evolutionary harmony for stinkbugs and their gut bacteria: A perfect match
7. Evolutionary first: Parasite reaches beyond host to play havoc with others sex lives
8. Evolutionary software to be released free of charge
9. APS Comparative-Evolutionary Physiology Conference showcases relevance of animal diversity
10. Evolutionary forces explain why women live longer than men
11. Evolutionary proof that (eating) the chicken came before the egg

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/7/2020)... ... 2020 , ... Nine middle school teachers from eight states ... unique professional development program that provides advanced STEM (science, technology, engineering and math) ... , Created in partnership between the National Stem Cell Foundation and The Gatton ...
(Date:7/31/2020)... ... July 30, 2020 , ... Justin Zamirowski to ... a near term focus on Type 2 diabetes and associated comorbidities. , Justin ... therapeutic areas and classes. As Chief Commercial Officer, Justin will lead Better ...
(Date:7/10/2020)... ... July 08, 2020 , ... ... and Gene Therapy Regulation, An FDAnews Webinar, Wednesday, July 22, 2020 • 1:30 ... study, but what is the most effective way to complete one? Will the ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... 2020 , ... The SDX® Respiratory Gating System , ... reached its 20th anniversary of worldwide use. Introduced in the US over the ... University of Pennsylvania, University of Michigan, University of Maryland, University of California San ...
(Date:7/18/2020)... , ... July 16, 2020 , ... “We are thrilled ... Wave Bioactives. “It’s the only technology of its kind on the market and we ... onions with the protective capacity of traditional cultured ingredients, creating a natural way to ...
(Date:7/10/2020)... ... July 09, 2020 , ... ... that Massachusetts Institute of Technology (MIT) has expanded the company’s exclusive license ... to move into the point-of-care diagnostic market, focusing initially on the SARS-CoV-2 ...
(Date:7/7/2020)... ... July 06, 2020 , ... Bio-IT ... Roche, Eli Lilly, Bristol-Myers Squibb, the University of Chicago, Massachusetts General Hospital, Mission: ... hosted an elite awards program, highlighting outstanding examples of how technology innovations and ...
Breaking Biology Technology:
Cached News: