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Exercise, aspirin consumption and childbirth may alter cancer risk

women, a finding that is consistent with our previous findings of altered proliferation in men, but not women. Therefore, physical activity may play a stronger role in colon cancer risk reduction among men than it does among women."

The researchers examined 101 men and 98 women in one of the first randomized clinical trials to test the effect of exercise on colon cancer. The participants either exercised or maintained their usual non-active lifestyle for one year. At the same time, researchers measured apoptosis by measuring the ratio of bax, the apoptosis promoter protein, to bcl-2, an anti-apoptotic protein. The researchers also determined where in the colon-crypt cells these apoptotic changes were occurring.

Cellular proliferation in the bottom of colon crypt cells is normal. But precancerous polyps (and ultimately, cancer) can develop when the crypt's cells proliferate too quickly. In that case, cells growing too fast creep up from the bottom and spill over the upper sides, resulting in the growths seen in cancer and its predecessors. The researchers previously found lower proliferation on the upper portions of crypt cells in exercising men, while no decreases were found in women or men who did not exercise.

Is the association between flame-broiled food, meat consumption, and breast cancer modified by N-acetytransferases and aspirin use?

By studying the eating patterns of 312 women with breast cancer and 316 who were cancer free in a prospective study, Kala Visvanathan, M.B.B.S., assistant professor of epidemiology at Johns Hopkins University, and colleagues found that women who eat flame-broiled foods more that twice a month may be at increased risk of breast cancer when compared to women who don't usually eat foods prepared that way.

The good news, however, is that taking aspirin negated the potentially harmful effects.

"We are not certain of the mechanism by which aspirin may be helping attenuate
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Contact: Warren Froelich
froelich@aacr.org
215-440-9300
American Association for Cancer Research
14-Nov-2006


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