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Exercise, aspirin consumption and childbirth may alter cancer risk

these risks. This is an area that further study should elucidate as we search for means to reduce the risk of breast cancer," said Visvanathan.

The researchers first sought to determine if differences in a women's ability to activate the cancer-provoking chemicals in flame-broiled meat, known as heterocyclic amines (HCAs), modified the risk of developing breast cancer.

The NAT2 enzyme, short for N-acteyltransferase, is involved with activating heterocyclic amines. Several genes control NAT2's ability to activate HCAs: slow NAT2 metabolizers tend to produce less active HCAs than fast NAT2 metabolizers. The study found that fast metabolizers who ate more flame-broiled food were more likely to develop breast cancer than slow metabolizers who never ate such food.

"Previous work examining the association between NAT2, flame-broiled food, and breast cancer risk has been inconsistent. We find the relationship between aspirin, flame-broiled food consumption and NAT2 activity intriguing," said Visvanathan.

Nonsteroidal anti-inflammatory drugs and breast cancer risk: the multiethnic cohort

Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) had little effect on reducing the risk of breast cancer overall; however, the risk was notably lower among African-American and Caucasian women with long-term use, according to a study by the University of Hawaii and University of Southern California.

The researchers' work is one of the first to explore the relationship between COX-2 inhibitors (aspirin and NSAIDs) and breast cancer in a multiethnic population. The National Cancer Institute is currently studying COX-2 drugs (short for cyclooxygenease-2) for its effect on breast cancer. The COX-2 enzyme is activated in response to inflammation and precancerous and cancerous tissues, and its inhibition has been associated with significant reduction in breast cancer tissue. A few large research studies have also show
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Contact: Warren Froelich
froelich@aacr.org
215-440-9300
American Association for Cancer Research
14-Nov-2006


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