Exercise doesn't work for us all

scular Research at the Children's Hospital at Westmead in Sydney. In the eight volunteers who showed the largest improvement in insulin sensitivity, 51 genes were expressed in muscles at double the levels of the eight people who showed the least improvement, and 74 genes were expressed at half the level. Many of these genes were a surprise to the researchers because they have not previously been linked to exercise. "We need to recognise that although on average exercise may have clear benefits, it may not work for everyone," says Mark Hargreaves of Deakin University in Melbourne. "Some people may do better to change their diet."



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