HOME >> BIOLOGY >> NEWS
'Exercise pill' switches on gene that tells cells to burn fat

By giving ordinary adult mice a drug - a synthetic designed to mimic fat - Salk Institute scientist Dr. Ronald M. Evans is now able to chemically switch on PPAR-d, the master regulator that controls the ability of cells to burn fat. Even when the mice are not active, turning on the chemical switch activates the same fat-burning process that occurs during exercise. The resulting shift in energy balance (calories in, calories burned) makes the mice resistant to weight gain on a high fat diet.

The hope, Dr. Evans told scientists attending Experimental Biology 2007 in Washington, DC, is that such metabolic trickery will lead to a new approach to new treatment and prevention of human metabolic syndrome. Sometimes called syndrome X, this consists of obesity and the often dire health consequences of obesity: high blood pressure, high levels of fat in the blood, heart disease, and resistance to insulin and diabetes.

Dr. Evan's Experimental Biology presentation on April 30 is part of the scientific program of the American Society for Biochemistry and Molecular Biology.

This chemical switch is not the first success Dr. Evan's laboratory has had in being able to turn on the PPAR-d switch in adipose or fat cells, activating local metabolism and increasing the amount of calories burned. As a Howard Hughes Medical Investigator at The Salk Institute's Gene Expression Laboratory, Dr. Evans discovered the role of the gene for PPAR-d, the master regulator of fat metabolism. By permanently turning on this delta switch in mice through genetic engineering, he was able to create a mouse with an innate resistance to weight gain and twice the physical endurance of normal mice. Because they were able to run an hour longer than a normal mouse, they were dubbed "marathon mice."

Subsequent work in the Evans laboratory found that activation of PPAR-d in these mice also suppresses the inflammatory response associated with arthrosclerosis.

<
'"/>

Contact: Sylvia Wrobel
ebpress@bellsouth.net
770-270-0989
Federation of American Societies for Experimental Biology
29-Apr-2007


Page: 1 2

Related biology news :

1. U-M researchers find family of on switches that cause prostate cancer
2. Beyond the DNA: Chemical signatures reveal genetic switches in the genome
3. Hairpins for switches
4. Gene therapy research switches off joint inflammation; switches on genetic process of joint repair
5. Flick of a protein switches immune response
6. Nano machine switches between biological and silicon worlds
7. Mutation in a single gene switches a fungus-grass symbiosis from mutualistic to antagonistic
8. Switching to new anti-bacterial targets: Riboswitches
9. Researchers improve design of genetic on-off switches
10. Genetic switches help fish adjust to fresh and salty water
11. Yale scientists find cooperative RNA switches in nature

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/26/2019)... ... , ... The American Society of Gene & Cell Therapy ... Achievement Award, Outstanding New Investigator Awards, and the Sonia Skarlatos Public Service Award. ... Meeting . , Outstanding Achievement Award, Dr. John Rossi, Lidow Family Research Endowed ...
(Date:3/25/2019)... (PRWEB) , ... March 25, 2019 , ... ... Interspersed Short Palindromic Repeats) gene editing technology since it came into use by ... Berkeley Visiting Scientist Kiana Aran is the first to combine the power of ...
(Date:3/23/2019)... PASADENA, Calif. (PRWEB) , ... March 22, 2019 ... ... Library Preparation Kit for Next Generation Sequencing (NGS) sample preparation. RhinoSeq employs a ... the NGS market. The five-tube kit is comprised of preformatted master mixes for ...
Breaking Biology News(10 mins):
(Date:3/19/2019)... ... 2019 , ... The AACR annual conference pulls together a diverse group of ... cancer research. The Visikol team will be at the show at booth #3252 and ... as their digital pathology services . “For AACR this year we are highlighting ...
(Date:3/19/2019)... ... 2019 , ... This free webinar will review strategies for data management in modular ... reduce study build times by up to 30 percent, reducing cost while increasing quality, achieving ... without the need to migrate data – reducing risk and impact on trial success, trial ...
(Date:3/15/2019)... ATLANTA (PRWEB) , ... March ... ... acquisition of 100% equity in American Process Inc. and affiliate companies including ... Alpena Biorefinery in Alpena Michigan, the Thomaston Biorefinery and R&D center in ...
(Date:3/14/2019)... ... March 14, 2019 , ... ON NOVEMBER 27, ... partner, the Eye Machine Canada Inc., had been given approval to begin a ... Age-Related Macular Degeneration (AMD). , The previous month, the medical devices bureau of ...
Breaking Biology Technology:
Cached News: