HOME >> BIOLOGY >> NEWS
Expanding complexity of p53

25 years after the initial discovery of p53, Dr. David Lane and colleagues at the University of Dundee have discovered multiple isoforms of the p53 tumor suppressor protein.

Their paper, which will be released online ahead of print in Genes & Development, establishes that, like the other p53 family members p63 and p73, p53 exists in human cells in at least six different isoforms. Dr. Lane and colleagues identified a heretofore unrecognized internal promoter and alternative splice exons in p53 mRNA.

While further research is needed to delineate how the various p53 isoforms affect p53 tumor suppressor activity, the scientists did establish that some p53 isoforms can modulate p53 transcriptional activity and p53-induced cell death. Interestingly, Prof. Lane and colleagues observed that p53 isoforms are abnormally expressed in breast tumors presenting no mutation of the p53 gene. David Lane and Jean-Christophe Bourdon, group leader in David Lane's laboratory, consider the discovery of p53 isoforms to be "a major breakthrough in the understanding of cancer formation.

The determination of p53 isoforms expression in human cancers will help to identify patients at risk of developing aggressive cancer and to define their drug sensitivity in order to treat the patient with the most efficient drug."


'"/>

Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
29-Aug-2005


Page: 1

Related biology news :

1. Doing nature one better: Expanding the genetic code in living mammalian cells
2. The long and the short of it: Expanding small RNA biology in mammals
3. Expanding waistlines triggered by your genes
4. Experts: Expanding biotechnology research in developing countries key to countering bioterrorism
5. Expanding forests darken the outlook for butterflies, study shows
6. Unravelling new complexity in the genome
7. First systematic study of Chinas one-child policy reveals complexity, effectiveness
8. NSF awards 17 grants for research on biocomplexity in the environment
9. Embryo fossils reveal animal complexity 10 million years before Cambrian Explosion
10. The complexity of tropical forest structure defies simple characterization
11. Evolution of irreducible complexity explained

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/20/2017)... -- PMD Healthcare announces the release of its new ... (WMS), a remote, real-time lung health monitoring and management ... a Medical Device, Digital Health, and Chronic Care Management ... solutions that empower people to improve their healthcare and ... the first ever personal spirometer, Spiro PD, which was ...
(Date:3/7/2017)... , March 7, 2017 Brandwatch , the ... by The Prince,s Trust to uncover insights to support ... The Trust. The UK,s leading youth charity will be ... campaign results and get a better understanding of the topics and ... ...
(Date:3/2/2017)... -- Who risk to be deprived of its imprint ... https://www.reportbuyer.com/product/4313699/ WILL APPLE AND SAMSUNG CONFRONT ... sensors using capacitive technology represent a fast growing market, ... an increase of 360% of the number of fingerprint ... sensor market between 2014 and 2017 (source : N+1 ...
Breaking Biology News(10 mins):
(Date:3/20/2017)... , ... March 20, 2017 , ... ... HEPARIN calibration verification / linearity test kit has received US FDA 510(k) clearance ... VALIDATE® HEPARIN kit evaluates Heparin Anti-Xa activity in a human plasma matrix. ...
(Date:3/20/2017)... NEW YORK , March 20, 2017  Attorney Advertising ... behalf of purchasers of the BioAmber Inc. ("BioAmber" or the "Company") ... obtain additional information and assist the investigation by visiting the ... concerns whether BioAmber and certain of its officers and/or directors ... Act of 1934. ...
(Date:3/19/2017)...  Array BioPharma Inc. (Nasdaq: ARRY ) ... Food and Drug Administration,s (FDA) Division of Oncology Products ... for the treatment of NRAS -mutant melanoma, a ... This action was based on thorough discussions and communications ... approval, and followed the late cycle review meeting held ...
(Date:3/18/2017)... , March 17, 2017  A new study ... who historically have been considered ineligible for curative ... reirradiation using intensity-modulated proton therapy (IMPT) for lung ... patients were free from local recurrence at one ... ten patients experienced severe side effects. The study ...
Breaking Biology Technology:
Cached News: