HOME >> BIOLOGY >> NEWS
Experience affects new neuron survival in adult brain; study sheds light on learning, memory

Experience in the early development of new neurons in specific brain regions affects their survival and activity in the adult brain, new research shows. How these new neurons store information about these experiences may explain how they can affect learning and memory in adults.

A team of researchers headed by Fred Gage, PhD, of the Salk Institute, found that experience enhances the survival of new neurons in a brain area called the dentate gyrus, and that more of these new neurons were activated when exposed to the same experience later. This change in function may be a mechanism for long-term memory. The findings are published in the March 21 issue of The Journal of Neuroscience.

"The results identify a critical period for experience-induced enhancement of new neuron survival in the hippocampus," says Elizabeth Gould, PhD, of Princeton University, who was not affiliated with the study. The hippocampus contains the dentate gyrus.

After injecting mice with a chemical used to mark proliferating cells, the researchers exposed the animals to an "enriched cage" environment, containing tunnels, shelters, and a running wheel. After several weeks, the researchers again exposed the mice in the same enriched experience. They discovered that the enriched experience increased new neuron survival and that more new neurons were activated by re-exposure to the same environment. To determine if the increase in neuronal activity was due to having the same experience or if any new experience was sufficient to achieve this effect, the researchers exposed mice to the enriched cage first and then a water maze task. While both cases promoted new neuron survival, more new neurons were activated in mice that had repeated the same experience but not in those that were exposed to the different experience (the water maze).

The researchers also compared the number of neurons at four weeks and four months after injections of the chemic
'"/>

Contact: Sara Harris
sharris@sfn.org
202-962-4000
Society for Neuroscience
22-Mar-2007


Page: 1 2

Related biology news :

1. Experience sculpts brain circuitry to build resiliency to stress
2. New clue why MS affects African-Americans differently than Caucasians
3. Sleep deprivation affects airport baggage screeners ability to detect rare targets
4. Economic impact of hunger affects all Americans
5. Sexual orientation affects how we navigate and recall lost objects, but age just targets gender
6. Growing nerve cells in 3-D dramatically affects gene expression
7. Estrogen fluctuation affects epileptic seizures
8. Race affects tobacco absorption in children
9. New diabetes research: Half of Americans have gene that affects how body burns sugar
10. Rutgers College of Nursing dean authors a book on genetics and how it affects nursing and health
11. Soil nutrition affects carbon sequestration in forests

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/19/2019)... ... August 19, 2019 , ... Since ... use of ultra-thin two dimensional slices which are placed on microscope slides, stained ... complex tissues and complicated features such as vasculature and thus researchers in the ...
(Date:8/15/2019)... ... ... Deep Science Ventures (DSV), a new paradigm for applied science, today announced ... 100 companies over the next 10 years to address the urgent need for new ... was founded to create a better method for launching science companies; one that takes ...
(Date:8/15/2019)... ... , ... Serialization deadlines in the US and European Union ... becomes fully applied in the United States in 2023, pharmaceutical companies are scrutinizing ... most regulations?including the Drug Supply Chain Security Act (DSCSA)?have required minimal system capabilities. ...
Breaking Biology News(10 mins):
(Date:8/15/2019)... ... August 15, 2019 , ... PathSensors announced today that Roger ... of the Institute of Food Technologists (IFT) Board of Directors, Illinois Institute of ... for Food Safety and Applied Nutrition (JIFSAN) Advisory Council and the University of ...
(Date:8/14/2019)... STATE COLLEGE, Pa. (PRWEB) , ... August 13, ... ... leader in nuclear receptor and in vitro toxicology testing solutions, announced the appointment ... of healthcare industry experience to the Board. , Mark McLoughlin will lend his ...
(Date:8/14/2019)... ... August 13, 2019 , ... ... prepackaged mobile phases for QC laboratories. After gaining a few significant clients, Lifecycle ... approach into a valued supplier of manufacturing processing solutions, including reagents for tissue ...
(Date:8/8/2019)... , ... August 08, 2019 , ... ... Agents for sales and service organizations, today announced that the company’s Studio ... Award for the IVA market . Inference will officially accept the award at ...
Breaking Biology Technology:
Cached News: