HOME >> BIOLOGY >> NEWS
Experience sculpts brain circuitry to build resiliency to stress

It's long been known that experiencing control over a stressor immunizes a rat from developing a depression-like syndrome when it later encounters stressors that it can't control. Now, scientists funded by the National Institute of Mental Health (NIMH), part of the National Institutes of Health (NIH), have unraveled the workings of the brain circuitry that inoculates against such hard knocks the circuitry of resilience.

Control not only activated the brain's executive hub, the prefrontal cortex, but also altered it so that it later activated even when the stressor was not controllable. This activation turned off mood-regulating cells in the brainstem's alarm center. The immunizing effect was so powerful that even a week later, when confronted with an uncontrollable stressor, the cells behaved as if the stressor was controllable and the rat was protected.

"It's as if the original experience with control leads the animal to later have the illusion of control even when it's absent, thereby producing resilience in the face of challenge," explained NIMH grantee Steven Maier, Ph.D., University of Colorado. "The prefrontal cortex is necessary for processing information about the controllability of stressors as well as applying this information to regulate responses to subsequent stressors."

A report on this first study exploring the neural mechanisms by which an initial experience with a controllable stressor can block the later behavioral effects of an uncontrollable stressor, by Maier, Jose Amat, Ph.D., and colleagues, appears in the December 20, 2006 issue of the Journal of Neuroscience.

"Lack of control over stressful life experiences has been implicated in mood and anxiety disorders," noted NIMH Director Thomas Insel, M.D. "Understanding how the brain encodes the experience of control to protect against such adverse consequences should help us develop better treatments for these disorders."

Rats exposed to unco
'"/>

Contact: Jules Asher
NIMHpress@nih.gov
301-443-4536
NIH/National Institute of Mental Health
21-Dec-2006


Page: 1 2 3

Related biology news :

1. Experience affects new neuron survival in adult brain; study sheds light on learning, memory
2. Invasion of the brain tumors
3. Preclinical study links gene to brain aneurysm formation
4. Gene variant is associated with brain anatomy, clinical course of ADHD
5. Human knowledge is based upon directed connectivity between brain areas
6. A sensory organ, not the brain, differentiates male and female behavior in some mammals
7. Reading ability protects brain from lead exposure
8. Strength of connections between brain regions may affect an adolescents response to peer influence
9. Females more prone to brain damage from alcohol abuse
10. Prenatal alcohol exposure alters brain activity in the frontal-striatal areas
11. Drug protects brain cells in Huntingtons disease model, researchers find

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/26/2020)... (PRWEB) , ... April 23, 2020 , ... ... specializing in computer miniaturization, backed by FII Tech Growth managed by Fondo Italiano ... in the biomedical market, for the development of Respira, a new non-invasive pulmonary ...
(Date:4/22/2020)... ... ... RCH Solutions (RCH ), a global provider of Bio-IT computing expertise ... Wlodarczyk as Director of Sales and Business Development. Based out of RCH’s location in ... presence across the Northeast. , “We continue to see increased demand for specialized scientific ...
(Date:4/22/2020)... ... , ... Worcester Polytechnic Institute (WPI) is expanding an existing science and engineering ... expected spike of COVID-19 cases. As part of its longtime Math and Science for ... other materials to be sent to six countries to facilitate the manufacturing of masks, ...
Breaking Biology News(10 mins):
(Date:5/14/2020)... ... May 13, 2020 , ... Early stages of ... little or no information on the drug’s mechanism of action (MOA). Gene expression ... by measuring the activity of molecular pathways. This information can complement phenotypic readouts ...
(Date:5/1/2020)... ... April 30, 2020 , ... ... today, honoring the businesses, policies, projects, and concepts that are actively engaged and ... for living cells, which has taken out the top prize in the Experimental ...
(Date:4/22/2020)... ... April 21, 2020 , ... Ripple Science ... Many clinical trial teams are working remotely and have paused patient visits, forcing ... researchers continue their research during this uncertain time by giving research teams free ...
(Date:4/1/2020)... ... March 30, 2020 , ... A joint venture between mobile ... earlier this year to bring telehealth to various government agencies, has now focused ... officials are currently?awaiting an Emergency Use Authorization (EUA) waiver from the FDA?to?perform?AI?testing in ...
Breaking Biology Technology:
Cached News: