HOME >> BIOLOGY >> NEWS
Expression of 'Blimp1' gene leads to the discovery of cells responsible for skin's sebaceous gland

Mice may not get zits, but they do have oily skin. This week, new research on mice from Rockefeller University shows how the cells responsible for oil production develop, and uncovers clues about how stem cells renew and differentiate.

The research focuses on the skins sebaceous gland, which is linked to the hair shaft and secretes an oily mixture called sebum. But until today how the sebaceous gland is formed during development was a matter of debate: one group of scientists proposed that skin stem cells produce the gland and a second group suggested that it had its own progenitor cells. In new research, published in the August 11 issue of Cell, Elaine Fuchs, a Howard Hughes Medical Institute investigator at Rockefeller University, settles this argument, showing that at the site where the sebaceous gland adjoins the hair follicle, a unique population of cells exists whose sole job is to make, and maintain, the sebaceous gland.

"We were exploring the expression of a transcription factor called Blimp1, which had surfaced in a genetic screen that we had conducted." explains Fuchs, who is the Rebecca C. Lancefield Professor and head of the Laboratory of Mammalian Cell Biology and Development at Rockefeller. "We were surprised to find that Blimp1 was expressed in a small population of cells within the sebaceous gland. We knew these cells were skin keratinocytes but no one had ever described their existence and therefore, we had no clues about their relationship to the gland."

Valerie Horsley, a postdoc in the Fuchs lab and first author of the paper, had been interested in Blimp1s role in hair follicle development, and had engineered mice that were missing the Blimp1 gene in their skin. "When the mice were born, they formed normal hair follicles, which was quite disappointing," says Horsley. "But when they were around one month of age I noticed that the mice starte
'"/>

Contact: Kristine Kelly
kkelly@rockefeller.edu
212-327-7146
Rockefeller University
10-Aug-2006


Page: 1 2

Related biology news :

1. Expression Project for Oncology (expO) collects 1,000th malignant tumor specimen
2. Acute sleep deprivation leads to changes in nighttime urine production for men and women
3. Biodesign Institute leads innovative project to prevent cancer
4. Screening approach leads to discovery of gene linked to breast cancer
5. Alcohol use during pregnancy leads to greater risk of extreme preterm delivery
6. Study of unexplained respiratory infections leads researchers to new virus
7. Penn leads $4 million grant to study gene-environment interactions in lung cancer
8. FSU leads botanical research into 21st century: Deep South Plant Specimen Imaging Project
9. Old dinosaur research leads to new honor
10. Long-term marijuana smoking leads to respiratory complaints
11. Trusting your instincts leads you to the right answer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... MONICA, Calif. , April 13, 2017 ... New York will feature emerging and evolving ... Summits. Both Innovation Summits will run alongside the expo ... of speaker sessions, panels and demonstrations focused on trending ... coast,s largest advanced design and manufacturing event will take ...
(Date:4/11/2017)... , April 11, 2017 NXT-ID, Inc. ... technology company, announces the appointment of independent Directors Mr. ... to its Board of Directors, furthering the company,s corporate governance ... Gino ... we look forward to their guidance and benefiting from their ...
(Date:4/4/2017)... , April 4, 2017   EyeLock LLC ... announced that the United States Patent and Trademark Office ... broadly covers the linking of an iris image with ... transaction) and represents the company,s 45 th issued ... patent is very timely given the multi-modal biometric capabilities ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... At its national board ... Suneel I. Sheikh, the co-founder, CEO and chief research scientist of Minnesota-based Advanced ... for membership in ARCS Alumni Hall of Fame . ASTER Labs is ...
(Date:10/11/2017)... ... 2017 , ... ComplianceOnline’s Medical Device Summit is back for its 4th year. ... San Francisco, CA. The Summit brings together current and former FDA office bearers, regulators, ... government officials from around the world to address key issues in device compliance, quality ...
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , ... of Cancer Research, London (ICR) and ... with SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple ... as MUK nine . The University of ... is partly funded by Myeloma UK, and ICR will perform ...
(Date:10/11/2017)... ... October 11, 2017 , ... Singh Biotechnology today announced ... to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of Transcription 3) B ... to cross the cell membrane and bind intracellular STAT3 and inhibit its function. ...
Breaking Biology Technology:
Cached News: