HOME >> BIOLOGY >> NEWS
Extra-aggressive form of idiopathic pulmonary fibrosis identified

Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disorder from which most patients die within 5 years after diagnosis. The disease is characterized by the insidious onset of dyspnea or cough and usually evolves slowly.

Now, Selman and coworkers present in an article published in the online, open-access journal PLoS ONE on Wednesday 30th May, strong evidence indicating that a subset of IPF patients has a short duration of symptoms before diagnosis and display an accelerated clinical course to end-stage disease. The authors postulate that these "rapid progressor" patients, predominantly smoking males, represent a distinct clinical phenotype compared with the usual "slow progressors" patients.

"These findings highlight the variability in the progression and outcome of IPF, and may explain, in part, the difficulty in obtaining significant and reproducible results in studies of therapeutic interventions in patients with IPF," said Dr Selman, who is the Director of Research at the National Institute of Respiratory Research in Mexico City and the lead author on this publication. "They also suggest that physicians should pay more attention to the time of onset of symptoms, and to look for other signs that allow the identification of these rapid progressor patients".

In this study the authors performed global gene expression analysis and other molecular studies in a subset of patients and identified a number of genes that were differentially expressed in both groups, suggesting that rapid progressors are biologically distinct from slow progressors.

"While preliminary, these results may allow investigators to identify biomarkers of disease progression," said Dr King, who is the Chief of Medicine at San Francisco General Hospital and an internationally renowned expert in research and management of pulmonary fibrosis.

The senior author on this paper, Dr Naftali Kaminski, who is the Director
'"/>

Contact: Moiss Selman
mselmanl@yahoo.com.mx
Public Library of Science
29-May-2007


Page: 1 2

Related biology news :

1. Gene expression patterns predict rapid decline in idiopathic pulmonary fibrosis patients
2. A candidate gene for familial idiopathic pulmonary fibrosis identified
3. New approach to pulmonary hypertension shows promise
4. Nitric oxide: Key to cardiovascular and pulmonary function and drug effectiveness
5. NIH gives PITT $13 million grant for chronic obstructive pulmonary disease research
6. Scientific meeting on pulmonary hypertension, December 7-8
7. Leveling the field for babies with persistent pulmonary hypertension
8. U-M scientists target key cells and signals that trigger pulmonary fibrosis
9. First different black/white mechanism in pulmonary fibrosis/scleroderma identified
10. Against pulmonary fibrosis
11. First report of cancer drug Gleevec as new target therapy for pulmonary hypertension

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/7/2016)... Avanade is helping Williams Martini Racing, one of ... biometric data in order to critically analyse every aspect ... against their rivals after their impressive, record-breaking pit stop ... with Williams during the 2016 season to capture and ... rate, temperature and peak acceleration) for key members of ...
(Date:12/6/2016)... Securus Technologies, a leading provider of ... safety, investigation, corrections and monitoring, and the Prison ... (5) year funding commitment by Securus to PEP ... and reentry support to more inmates and their ... the Prison Entrepreneurship Program (PEP) is an independent ...
(Date:11/30/2016)... Nov. 30, 2016 Not many of us realize that we spend ? ... so we need to do it well. Inadequate sleep levels have been found to ... stroke, diabetes, and even cancer. Maybe now is the best time to ... help them to manage their sleep quality? Continue Reading ... ...
Breaking Biology News(10 mins):
(Date:12/6/2016)... , ... December 06, 2016 ... ... the Almac Group, the world’s largest privately-held contract pharmaceutical development and manufacturing ... Health, a leading biopharma outsourcing company combining a leading CRO and the ...
(Date:12/6/2016)... ... December 06, 2016 , ... Symbios Technologies, Inc. , ... company has engaged in a collaborative research partnership with Colorado State University (CSU) ... of the Vice President for Research. This agreement is designed to further the ...
(Date:12/6/2016)... -- Zimmer Biomet Holdings, Inc. (NYSE and SIX: ... of its previously-announced cash tender offers (the "Offers") ... accrued and unpaid interest to, but not including, ... expenses related to the Offers) (the "Maximum Tender ... table below (collectively, the "Notes"). The terms and ...
(Date:12/6/2016)... ... December 06, 2016 , ... ... management solutions headquartered in Aurora, Ohio, announced the opening of their new office ... the newly constructed facility is home to 200 employees focused on providing sales, ...
Breaking Biology Technology:
Cached News: