Extracting eggs from pre-pubertal cancer patients brings hope for future fertility

Lyon, France -- Scientists in Israel have been able to obtain and freeze eggs from the ovarian tissue of girls as young as 5 years old, the 23rd annual conference of the European Society of Human Reproduction and Embryology will hear on Tuesday (3 July). Dr. Ariel Revel, from the Department of Obstetrics and Gynaecology, Hadassah University Hospital, Jerusalem, Israel, said that the growing number of survivors of childhood cancers meant that such techniques would become increasingly important in preserving fertility in young patients.

Childhood cancers usually result in cure rates of between 70% and 90%, and are generally more responsive to therapy than adult cancers. However, the aggressive chemotherapy which is often necessary usually means that children will be sterile in later life. In adult women, the ovaries are stimulated to produce eggs which are removed, fertilised and frozen.

In younger girls this is not possible, and the method normally used is to freeze the ovarian cortex, which contains the egg-producing follicles, for transplantation at a later date. But the cortex is often damaged by freezing, and collecting and freezing individual eggs from the follicles, which are more resistant to the damage caused by extreme cold, offers a better chance of restoring fertility in adulthood.

To their surprise, Dr. Revel and his team found eggs in the follicles of girls between 5 and 10 years old who had not reached puberty. We were able to extract oocytes using needle aspiration from very young girls, he said. For example, we found 7 eggs in a girl of 5 years old with Wilms tumour, 8 in an 8 year old with Ewings sarcoma, and 17 in a ten year old, also with Ewings sarcoma. We were then able to mature the eggs in vitro and freeze them for use in the future.

The median age in the study group was 16, and eggs were found in all but one patient, herself aged 16. A total of 167 eggs were found, with an average of

Contact: Mary Rice
European Society for Human Reproduction and Embryology

Page: 1 2

Related biology news :

1. Protein chatter linked to cancer activation
2. Newly created cancer stem cells could aid breast cancer research
3. Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
4. ESF EURYI award winner aims to stop cancer cells reading their own DNA
5. No evidence that widely prescribed statins protect against prostate cancer
6. A study by the MUHC and McGill University opens a new door to understanding cancer
7. New study suggests Concord grape juice may provide protection against breast cancer
8. New test improves detection of liver cancer
9. High-intensity ultrasound may launch attack on cancer, wherever it lurks
10. Unknotting DNA clue to cancer syndrome
11. Biologists at Tufts University discover 1 reason why chromosomes break, often leading to cancer

Post Your Comments:

(Date:9/25/2019)... ... , ... Modality Solutions, a biopharmaceutical cold chain ... annual Inc. 5000 list, the most prestigious ranking of the nation’s fastest-growing private ... growth, the Houston-based firm also ranked No. 47 in its industry category of ...
(Date:9/25/2019)... ... ... Deep Science Ventures (DSV), a new paradigm for applied science, today ... research. , Deep Science Ventures was founded to create a better method for launching ... start, both at the industry and biological level. , Through their partnership with ...
(Date:9/24/2019)... Fla. (PRWEB) , ... September 24, 2019 , ... ... of its technology driven portfolio of 3D porous titanium spinal implants with the ... it’s Ti3D implant offerings while more than tripling the number of cervical and ...
Breaking Biology News(10 mins):
(Date:9/24/2019)... ... September 24, 2019 , ... Personalized Stem ... and site qualification for clinical trial sites and physician investigators. The clinical ... clinical trial participants. , Clinical trial sites are currently located in San Diego ...
(Date:9/22/2019)... (PRWEB) , ... September 20, 2019 , ... ... launch of Brain-Derived Neurotrophic Factor (BDNF) testing in serum . BDNF plays ... systems. BDNF stimulates the growth and differentiation of new neurons in the brain ...
(Date:9/17/2019)... ... September 17, 2019 , ... ... success in chronic diseases, announces today that the U.S. Patent and Trademark Office ... genetic algorithm to rank drug class recommendations for hypertension treatment. , The ...
(Date:9/17/2019)... ... September 16, 2019 , ... A new episode of ... @11:00am ET. Check local listings for more information on this program. , The ... diagnostic company from Singapore dedicated to developing advanced diagnostic technologies for the masses. ...
Breaking Biology Technology:
Cached News: