HOME >> BIOLOGY >> NEWS
Eye candy: Transcriptional control of vertebrate eye development

Dr. Greg Lemke and colleagues have determined that two ventral anterior homeobox (Vax) genes act as intracellular effectors of Shh signaling in the developing eye field and are required for proper optic nerve formation. During embryogenesis, the optic vesicle is strictly compartmentalized into dorsal and ventral domains, the former of which gives rise to the retina, and the latter of which forms the optic nerve.

By creating Vax1/2 double knock-out mice, Dr. Lemke and colleagues found that Vax1 and Vax2 are necessary for the repression of Pax6 expression, the ventralization of the eye field, and subsequent development of the optic nerve. Dr. Lemke notes that "in many respects, the eyes represent a default differentiation pathway for the front end of the developing brain. To make an optic nerve and connect the eyes to the rest of the brain, this default pathway must be blocked and re-directed, and that's what the Vax genes do."


'"/>

Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
14-May-2005


Page: 1

Related biology news :

1. Location, location, location: Transcriptional activity and nuclear position
2. Circadian clock controls plant growth hormone
3. Weizmann Institute scientists discover a control mechanism for metastasis
4. Researchers find pathway that controls cell size and division
5. Penn researchers discover how microRNAs control protein synthesis
6. Biocontrol of invasive water hyacinth contributes to socioeconomic and health improvements in Africa
7. Amoebae control cheating by keeping it in the family
8. Revealed -- Mosquito genes that could be controlling the spread of killer viruses
9. Autism-related proteins control nerve excitability, researchers find
10. Weizmann Institute scientists develop a general control switch for protein activity
11. Researchers demonstrate way to control tree height

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: