HOME >> BIOLOGY >> NEWS
Eye candy: Transcriptional control of vertebrate eye development

Dr. Greg Lemke and colleagues have determined that two ventral anterior homeobox (Vax) genes act as intracellular effectors of Shh signaling in the developing eye field and are required for proper optic nerve formation. During embryogenesis, the optic vesicle is strictly compartmentalized into dorsal and ventral domains, the former of which gives rise to the retina, and the latter of which forms the optic nerve.

By creating Vax1/2 double knock-out mice, Dr. Lemke and colleagues found that Vax1 and Vax2 are necessary for the repression of Pax6 expression, the ventralization of the eye field, and subsequent development of the optic nerve. Dr. Lemke notes that "in many respects, the eyes represent a default differentiation pathway for the front end of the developing brain. To make an optic nerve and connect the eyes to the rest of the brain, this default pathway must be blocked and re-directed, and that's what the Vax genes do."


'"/>

Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
14-May-2005


Page: 1

Related biology news :

1. Location, location, location: Transcriptional activity and nuclear position
2. Circadian clock controls plant growth hormone
3. Weizmann Institute scientists discover a control mechanism for metastasis
4. Researchers find pathway that controls cell size and division
5. Penn researchers discover how microRNAs control protein synthesis
6. Biocontrol of invasive water hyacinth contributes to socioeconomic and health improvements in Africa
7. Amoebae control cheating by keeping it in the family
8. Revealed -- Mosquito genes that could be controlling the spread of killer viruses
9. Autism-related proteins control nerve excitability, researchers find
10. Weizmann Institute scientists develop a general control switch for protein activity
11. Researchers demonstrate way to control tree height

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/3/2016)... --> --> ... Fingerprint Identification System Market by Component (Hardware and Software), ... Finance, Government, Healthcare, and Transportation) and Geography - Global ... expected to be worth USD 8.49 Billion by 2020 ... 2020. The transformation and technology evolution from the manual ...
(Date:2/2/2016)... 2016 This BCC Research report provides ... reviewing the recent advances in high throughput ‘omic ... field forward. Includes forecast through 2019. ... and opportunities that exist in the bioinformatic market. ... as well as IT and bioinformatics service providers. ...
(Date:2/2/2016)... VIEW, Calif. , Feb. 2, 2016 /PRNewswire/ ... retinopathy market, Frost & Sullivan recognizes US-based Intelligent ... America Frost & Sullivan Award for New Product ... provider in North America , ... in the rapidly growing diabetic retinopathy market. The ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... 10, 2016  IsoRay, Inc. (NYSE MKT: ISR), a ... medical radioisotope applications for the treatment of prostate, brain, ... its financial results for the second quarter and six ... --> --> ... fiscal 2016, which ended December 31, 2015, a 12% ...
(Date:2/10/2016)... Latham, NY (PRWEB) , ... February 10, 2016 , ... ... photodiode packages at the SPIE Photonics West conference in San Francisco’s Moscone ... and 14 in the same venue. , These latest InGaAs PIN diode standard ...
(Date:2/10/2016)... , ... February 10, 2016 , ... Cenna Bioscience Inc., ... the treatment of Alzheimer’s disease, announced today it has been selected to present at ... the Breakers in Palm Beach, Florida. The purpose of the Forum is to ...
(Date:2/9/2016)... ... February 08, 2016 , ... ... services, announced today the launch of its revamped and improved website. In an ... service solutions, the redesigned website will better communicate how the company designs and ...
Breaking Biology Technology:
Cached News: