HOME >> BIOLOGY >> NEWS
Eye candy: Transcriptional control of vertebrate eye development

Dr. Greg Lemke and colleagues have determined that two ventral anterior homeobox (Vax) genes act as intracellular effectors of Shh signaling in the developing eye field and are required for proper optic nerve formation. During embryogenesis, the optic vesicle is strictly compartmentalized into dorsal and ventral domains, the former of which gives rise to the retina, and the latter of which forms the optic nerve.

By creating Vax1/2 double knock-out mice, Dr. Lemke and colleagues found that Vax1 and Vax2 are necessary for the repression of Pax6 expression, the ventralization of the eye field, and subsequent development of the optic nerve. Dr. Lemke notes that "in many respects, the eyes represent a default differentiation pathway for the front end of the developing brain. To make an optic nerve and connect the eyes to the rest of the brain, this default pathway must be blocked and re-directed, and that's what the Vax genes do."


'"/>

Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
14-May-2005


Page: 1

Related biology news :

1. Location, location, location: Transcriptional activity and nuclear position
2. Circadian clock controls plant growth hormone
3. Weizmann Institute scientists discover a control mechanism for metastasis
4. Researchers find pathway that controls cell size and division
5. Penn researchers discover how microRNAs control protein synthesis
6. Biocontrol of invasive water hyacinth contributes to socioeconomic and health improvements in Africa
7. Amoebae control cheating by keeping it in the family
8. Revealed -- Mosquito genes that could be controlling the spread of killer viruses
9. Autism-related proteins control nerve excitability, researchers find
10. Weizmann Institute scientists develop a general control switch for protein activity
11. Researchers demonstrate way to control tree height

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/12/2016)... WearablesResearch.com , a brand of Troubadour Research & ... Q1 wave of its quarterly wearables survey. A particular ... a program where they would receive discounts for sharing ... "We were surprised to see that so many ... CEO of Troubadour Research, "primarily because there are segments ...
(Date:4/26/2016)... and LONDON , April 26, ... of EdgeVerve Systems, a product subsidiary of Infosys ... announced a partnership to integrate the Onegini mobile ...      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) ... customers enhanced security to access and transact across ...
(Date:4/14/2016)... Israel , April 14, 2016 ... Authentication and Malware Detection, today announced the appointment of ... assumed the new role. Goldwerger,s leadership appointment ... on the heels of the deployment of its platform ... BioCatch,s behavioral biometric technology, which discerns unique cognitive and ...
Breaking Biology News(10 mins):
(Date:5/18/2016)... ... May 18, 2016 , ... ... are a direct result of asthma complications.* Costing more than $56 billion in ... , “For too many, the suffering associated with uncontrolled asthma ...
(Date:5/18/2016)... ... , ... Ryan Benton was diagnosed with Duchenne Muscular Dystrophy (DMD) at the ... twenties. DMD is a relatively common progressive genetic disorder, which causes aggressive deterioration of ... critical. He met with the founder of the Stem Cell Institute in ...
(Date:5/17/2016)... ... May 17, 2016 , ... DryLet, LLC, a biotechnology ... today it will be showcasing ManureMagic™ at booth V1061 at the World Pork ... Wall Street Journal last year and more recently made news as the results ...
(Date:5/17/2016)... ... 17, 2016 , ... PATH and Laerdal Global Health announced ... a feeding cup to market based on a reference design co-developed by PATH, ... Children’s Hospital, thereby ensuring an innovative feeding option for the 7.6 million preterm ...
Breaking Biology Technology:
Cached News: