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FLT PET assesses treatment response on tumor growthnot sizewith non-Hodgkin's lymphoma

he antibody Rituximab led to a temporary increase of FLT uptake in several patients, perhaps reflecting an upregulation (an increase in the number of receptors on the surface of target cells) of DNA synthesis within the lymphoma cell compartment or a recruitment and proliferation of tumor-invading lymphocytes, noted Herrmann. "In contrast, CHOP led to a rapid decrease of FLT uptake early after application--presumably due to a reduction of tumor cell proliferation," he said.


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Contact: Maryann Verrillo
mverrillo@snm.org
703-708-9000
Society of Nuclear Medicine
6-Jun-2006


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