HOME >> BIOLOGY >> NEWS
Fat deficiency gene also spurs obesity

A gene earlier found to underlie lipodystrophy--a disorder characterized by a severe deficiency of fat--can also spur obesity, according to new research published in the premier issue of Cell Metabolism. The gene, which alters fat storage and metabolism, is the first found to adjust body fat content up or down, depending on its expression level in fat and muscle, according to the researchers.

The gene might therefore represent a novel peripheral target for the treatment of obesity and lipodystrophy, they said. The finding further suggests that differences in lipin might contribute to the natural range of fat levels found among people.

The group, led by Karen Reue of the David Geffen School of Medicine and the University of California, Los Angeles found that excess levels of lipin, in either the fat tissue or skeletal muscle of mice, promote obesity. The protein operates through diverse mechanisms to affect body weight, they show. While lipin in fat influences the storage capacity of fat cells, in muscle the protein determines whole-body energy expenditure and the rate at which the body burns fat.

"Lipodystrophy and obesity represent extreme and opposite ends of the adiposity spectrum and have typically been attributed to alterations in the expression or function of distinct sets of genes," Reue said. "Lipin represents the first gene with the capacity to go both ways on the scale, modulating body fat content from one extreme to the other."

Lipin is normally found in metabolically active tissues such as fat and skeletal muscle. Mice lacking lipin exhibit lipodystrophy, with symptoms including a severe deficiency of adipose tissue and insulin resistance. A deficiency of lipin prevents both diet-induced and genetic obesity and is required for the normal development of mature fat cells, Reue's team reported last year.

To further elucidate lipin's role, the researchers generated transgenic mice with enhanced expression of the gene
'"/>

Contact: Heidi Hardman
hhardman@cell.com
1-617-397-2879
Cell Press
18-Jan-2005


Page: 1 2

Related biology news :

1. Study suggests estrogen deficiency can lead to obesity-induced high blood pressure after menopause
2. G6PD deficiency is associated with significant protection against severe, life-threatening malaria
3. Vitamin D deficiency widespread during pregnancy
4. The new form of trypanosomiasis discovered in India stems from a deficiency in apolipoproteinL-1
5. Poor athletic performance linked to vitamin deficiency
6. Dartmouth study contributes to research addressing malnutrition and iron deficiency
7. Heavy drinking can hasten the progression of the simian immunodeficiency virus disease
8. Study illuminates birth defects caused by copper deficiency
9. Study finds that nutritionally enhanced rice reduces iron deficiency
10. Enzyme deficiency may contribute to liver cancer, Mount Sinai research indicates
11. Gene for immune deficiency syndromes found

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... MONICA, Calif. , April 13, 2017 ... New York will feature emerging and evolving ... Summits. Both Innovation Summits will run alongside the expo ... of speaker sessions, panels and demonstrations focused on trending ... coast,s largest advanced design and manufacturing event will take ...
(Date:4/11/2017)... BEACH GARDENS, Fla. , April 11, 2017 ... identity management and secure authentication solutions, today announced ... contract by Intelligence Advanced Research Projects Activity (IARPA) ... for IARPA,s Thor program. "Innovation has ... onset and IARPA,s Thor program will allow us ...
(Date:4/11/2017)... N.Y. , April 11, 2017 ... fingerprints, but researchers at the New York University ... College of Engineering have found that partial similarities ... security systems used in mobile phones and other ... thought. The vulnerability lies in the ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Proscia Inc ., a ... Webinar titled, “Pathology is going digital. Is your lab ready?” with Dr. Nicolas ... practices and how Proscia improves lab economics and realizes an increase in diagnostic ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... implantation and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... and maternal age to IVF success. , After comparing the results from the ...
(Date:10/10/2017)... ... October 10, 2017 , ... For the ... won a US2020 STEM Mentoring Award. Representatives of the FirstHand program travelled to ... Experience from US2020. , US2020’s mission is to change the trajectory of STEM ...
(Date:10/10/2017)... CALIFORNIA (PRWEB) , ... October 10, 2017 , ... ... technological innovation and business process optimization firm for the life sciences and healthcare ... BoxWorks conference in San Francisco. , The presentation, “Automating GxP Validation for ...
Breaking Biology Technology:
Cached News: