HOME >> BIOLOGY >> NEWS
Fat fish put obesity on the hook

Everyone knows that eating lean fish helps slim waistlines, but researchers from the Center for the Study of Weight Regulation and Associated Disorders at Oregon Health and Science University in Portland, OR, have found a new way fish can help eliminate obesity. In a study to be published in the July 2007 print issue of The FASEB Journal, researchers describe the first genetic model of obesity in a fish. Having this model should greatly accelerate the development of new drugs to help people lose weight and keep it off.

According to corresponding author Roger Cone, Being able to model human disorders like obesity in zebrafish allows scientists to understand the molecular basis of disease. This may ultimately increase the efficiency and power of the drug discovery process, thus bringing new medicines to the market faster and cheaper.

In the study, researchers caused obesity in zebrafish by introducing the same type of genetic mutation that causes severe obesity in humans. The genetic change blocks the activity of a receptor, the melanocortin-4 receptor, which is at the heart of a device in our brains called the adipostat. The adipostat regulates body weight homeostatically, like the thermostat in a house, and works to keep long-term energy storesa.k.a. body fatconstant. The adipostat is what makes it difficult for people to lose weight and keep it off.

Americanseven childrenare getting fat at an alarming rate, said Gerald Weissmann, MD, Editor-in-Chief of The FASEB Journal, and with this model, we are a step closer to temporarily turning off or diminishing the fat-storing mechanisms that were once crucial to the survival of our species. The zebrafish has become a model animal for the study of many diseases because it has a backbone and because its genetics have been well described. This is one more example of how basic experimental biology zoology physiology and genetics in this case can be brought to bear on human problems.'"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
18-Jun-2007


Page: 1 2

Related biology news :

1. Study suggests estrogen deficiency can lead to obesity-induced high blood pressure after menopause
2. Monell researchers find metabolic defect in liver that can lead to obesity
3. Adult survivors of childhood leukemia exercise less, worsening high risk for obesity and illness
4. New role for protein in fat cells may improve understanding of obesity and diabetes
5. Link between obesity and enlarged heart discovered by University of Arizona researchers
6. Uncovering the molecular basis of obesity
7. Fat tissue-derived hormone leptin increases e-cadherin expression, obesity-breast cancer link noted
8. Food cue-related brain activity linked to obesity?
9. Humans arent the only ones with obesity problems
10. Hot flashes -- Studies explore the role of genes, obesity and alcohol
11. A relative of anti-aging gene Klotho also influences metabolic activity, obesity

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2017)... 27, 2017  Catholic Health Services (CHS) has ... Society (HIMSS) Analytics for achieving Stage 6 on ... . In addition, CHS previously earned a place ... an electronic medical record (EMR). "HIMSS ... of EMR usage in an outpatient setting.  This ...
(Date:3/24/2017)... The Controller General of Immigration from Maldives Mr. ... have received the prestigious international IAIR Award for the most innovative ... ... Maldives Immigration ... Algeen (small picture on the right) have received the IAIR award for ...
(Date:3/24/2017)... Research and Markets has announced the addition of the ... Forecast to 2025" report to their offering. ... The Global Biometric Vehicle Access System ... over the next decade to reach approximately $1,580 million by 2025. ... forecasts for all the given segments on global as well as ...
Breaking Biology News(10 mins):
(Date:3/27/2017)... , March 27, 2017 Neurotrope, ... novel therapies for neurodegenerative diseases, including Alzheimer,s disease, ... its application to list the Company,s common stock ... by The NASDAQ Stock Market, a unit of ... listing, Neurotrope will ring the Opening Bell at the ...
(Date:3/24/2017)... DUBLIN , Mar. 24, 2017 Research ... Stem Cell (hESC) Research - Global Strategic Business Report" report ... ... Cell (hESC) Research in US$ Million. Annual estimates and forecasts are ... are derived from primary and secondary research. The ...
(Date:3/24/2017)...   Sienna Biopharmaceuticals, Inc. , a privately held, ... Richard Peterson will join the company as ... who brings more than two decades of global financial ... retiring at the end of April but will continue ... Sienna from Novan, Inc., where he served as Chief ...
(Date:3/23/2017)... , ... March 23, 2017 , ... Lajollacooks4u is proud to announce it has become ... hosted corporate cooking challenges for companies around the world, such as Illumina, HP and Qualcomm, ... the reason for its increasing popularity is due to its new team building format, a ...
Breaking Biology Technology:
Cached News: