HOME >> BIOLOGY >> NEWS
Fat-generated hormone drives energetic capacity of muscle

The fat-generated hormone adiponectin plays an important role in the energetic capacity of skeletal muscle, according to a new study in the July, 2006, Cell Metabolism, published by Cell Press. Adiponectin is unusual among fat hormones in that its levels generally decline in those who are obese.

The researchers report evidence in people and mice, linking low adiponectin levels to insulin resistance and reductions in the number of "cellular power plants" called mitochondria in skeletal muscle. The findings suggest that therapies designed to boost the adiponectin signal might prove beneficial for the treatment of insulin resistance and diabetes, they said.

"We have discovered a skeletal muscle pathway by which adiponectin increases mitochondrial number and function and exerts antidiabetic effects," said lead author Anthony Civitarese from Pennington Biomedical Research Center in Baton Rouge, Louisiana.

Mitochondria utilize nutrient components, including fats and carbohydrates, to generate usable energy. The number of mitochondria therefore influences the way that muscles function. For example, people who exercise regularly have more mitochondria in their muscles than do those who are sedentary.

Earlier studies found that obese individuals and those with type 2 diabetes have reduced adiponectin concentrations, the researchers said. The new study examined the effects of that reduced adiponectin on skeletal muscle.

The researchers first examined children whose parents had type 2 diabetes and those with no family history of the disease. Muscle taken from individuals prone to diabetes was insulin resistant and had lower than normal concentrations of mitochondrial enzymes, suggesting some dysfunction, they found. The level of adiponectin also correlated with the estimated number of mitochondria in the muscle samples.

Further study of adiponectin-deficient mice similarly found that the animals were resistant to insulin
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
5-Jul-2006


Page: 1 2

Related biology news :

1. Circadian clock controls plant growth hormone
2. Role of thyroid hormones in slumber under investigation at Rutgers
3. Breast cancer and hormone therapy -- A looking-glass mirror?
4. IMS updated recommendations on postmenopausal hormone therapy
5. Fat tissue-derived hormone leptin increases e-cadherin expression, obesity-breast cancer link noted
6. Steroid hormones regulate the body clock
7. Scientists find hormone activity explains adolescent mood swings
8. Pregnancy hormone increases nerve cells insulation, restores damage
9. Pregnancy hormone key to repairing nerve cell damage
10. Male sweat boosts womens hormone levels
11. Joslin-led study uncovers role of appetite hormone MCH in insulin production

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/19/2017)... 2017 The global military biometrics ... marked by the presence of several large global players. ... five major players - 3M Cogent, NEC Corporation, M2SYS ... nearly 61% of the global military biometric market in ... global military biometrics market boast global presence, which has ...
(Date:4/11/2017)... , April 11, 2017 Crossmatch®, a ... authentication solutions, today announced that it has been ... Research Projects Activity (IARPA) to develop next-generation Presentation ... "Innovation has been a driving force ... program will allow us to innovate and develop ...
(Date:4/5/2017)... April 5, 2017  The Allen Institute for Cell ... Explorer: a one-of-a-kind portal and dynamic digital window into ... data, the first application of deep learning to create ... cell lines and a growing suite of powerful tools. ... these and future publicly available resources created and shared ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... ... June 21, 2017 , ... RMC Pharmaceutical Solutions, ... engages Timothy Reinhardt to manage the new site. , Tim has 25 years ... his most recent role as the Director of Manufacturing and Supplier Quality Assessment. ...
(Date:6/22/2017)... ... June 22, 2017 , ... AESKU.GROUP, ... DST Diagnostische Systeme & Technologien GmbH, thereby expanding its product portfolio to include ... hay fever, urticaria, asthma, atopic eczema or a food allergy. Allergies are escalating ...
(Date:6/22/2017)... ... June 22, 2017 , ... ... RegMedNet has produced a Spotlight series on “Cell Therapy ... and perspectives by leading experts on the unique regulatory challenges of stem cell ...
(Date:6/22/2017)... , ... June 22, 2017 , ... The first human ... 20 years until the first data on cross-contamination of human cell lines with HeLa ... an increasing issue in cell culture labs and is associated with dramatic consequences for ...
Breaking Biology Technology:
Cached News: