HOME >> BIOLOGY >> NEWS
Fat tissue-derived hormone leptin increases e-cadherin expression, obesity-breast cancer link noted

Being obese increases the risk of breast cancer in post-menopausal women, shortens the time between return of the disease and lowers overall survival rates. Italian researchers speaking at Experimental Biology 2007 in Washington, DC, now report evidence on how leptin, a hormone found in fat cells, significantly influences breast cancer development and progression in mice. This new understanding, says Dr. Sebastiano Ando, establishes a new mechanism for the link between obesity and breast cancer and suggests new targets for drugs that could intervene in that mechanism.

Dr. Ando's presentation on Sunday, April 29 is part of the scientific program of the American Society of Investigative Pathology.

Leptin, an adipocyte-derived hormone, is best known for its efforts to send messages to the body that no more food is needed, a process that may go awry in many people with obesity. But it also is involved in many other processes, from reproduction and lactation to cell differentiation and proliferation. Leptin is activated by signals from the leptin receptor ObR, and it is this partnership that has previously been found to be involved in the development of breast cancer. It was recently reported, for example, that leptin was detected in 86.4 percent of primary breast tumors and that its expression was highly correlated with ObR.

In previous studies in Dr. Ando's laboratory, leptin was demonstrated to play a significant role in promoting breast cancer in obese women by increasing the amount of estrogen (estradiol) in breast tissue. In the current study, the researchers found that leptin also upregulated or increases the production of E-cadherin, an intercellular adhesion molecule generally viewed as a tumor suppressor. The researchers grafted human breast cancer tissue in "nude" mice (genetically bred to be unable to reject tumors and therefore a frequently used animal in cancer research) and also in a three dimensional tissue culture which
'"/>

Contact: Sylvia Wrobel
ebpress@bellsouth.net
770-270-0989
Federation of American Societies for Experimental Biology
29-Apr-2007


Page: 1 2

Related biology news :

1. Circadian clock controls plant growth hormone
2. Role of thyroid hormones in slumber under investigation at Rutgers
3. Breast cancer and hormone therapy -- A looking-glass mirror?
4. IMS updated recommendations on postmenopausal hormone therapy
5. Steroid hormones regulate the body clock
6. Scientists find hormone activity explains adolescent mood swings
7. Pregnancy hormone increases nerve cells insulation, restores damage
8. Pregnancy hormone key to repairing nerve cell damage
9. Male sweat boosts womens hormone levels
10. Joslin-led study uncovers role of appetite hormone MCH in insulin production
11. Natural gut hormone offers hope for new obesity drug

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2020)... ... August 19, 2020 , ... ... and SalivaBio LLC, businesses dedicated to Salivary Bioscience for more than twenty years. ... published book by Springer, " Salivary Bioscience: Foundations of Interdisciplinary Saliva Research and ...
(Date:8/21/2020)... ... August 20, 2020 , ... NDA Partners Chairman ... Operations executive with expertise in clinical trial planning and feasibility, regulatory inspection readiness, ... Consultant. Throughout his career, Mr. Movahhed has helped design and manage oncology, neurology, ...
(Date:8/12/2020)... ... August 12, 2020 , ... Mosio recently announced its ... public health agencies of all sizes. With a focus on tracking symptoms and ... appropriate health care, Mosio helps public health departments automate communications and provide more ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... 29, 2020 , ... Anomet Products has introduced new custom ... use with CRM, neurostimulation, vascular, and related devices. , Anomet Medical Clad ... performance, and cost criteria; especially where solid wire is limited. Typical configurations for ...
(Date:7/31/2020)... ... , ... eSource has long been touted as the solution to high data ... the reasons it did not take off as quickly as people initially expected, and ... moving towards capturing data electronically for clinical trials and then repurposing it for downstream ...
(Date:7/31/2020)... ... July 30, 2020 , ... ... industry, today announced the release of its signature product called Beacon - ... (MSLs) and other field medical professionals. , Beacon helps MSLs streamline ...
(Date:7/18/2020)... ... July 16, 2020 , ... After research model surgery ... of a great surgery is only the beginning of a successful study, while protecting ... , Join Brad Gien, Global Head of Surgery from Envigo in a ...
Breaking Biology Technology:
Cached News: