Fat tissue-derived hormone leptin increases e-cadherin expression, obesity-breast cancer ...( closely mimics biological features of ...)

Fat tissue-derived hormone leptin increases e-cadherin expression, obesity-breast cancer link noted

closely mimics biological features of tumors. The results were the same in both. Combined exposure to leptin and estradiol increased tumor size, sometimes doubling it, and these changes correlated with an increase in E-cadherin.

Dr. Ando and his colleagues believe from their data that it is reasonable to suggest that the tumor suppressor E-cadherin may serve as a tumor enhancer when exposed to leptin and estradiol, that its ability to help cells aggregate then enhances the transformation of normal cells to cancerous cones, stimulating the growth of tumor mass.

When the researchers used an E-cadherin antibody or a calcium-chelating agent to block E-cadherin function in the present of estradiol, this enhanced cell growth stopped.

Contact: Sylvia Wrobel
ebpress@bellsouth.net
770-270-0989
Federation of American Societies for Experimental Biology
29-Apr-2007

Page: 1 2
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